{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:54:56Z","timestamp":1781762096465,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008679","name":"Universidad de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Res. Metr. Anal."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite major investments in neglected tropical diseases (NTDs) research over the past two decades, it remains unclear whether global scientific production aligns with population-level health indicators. To address this gap, we designed and implemented a comprehensive meta-research analysis pipeline to quantify the scientific coherence between global NTDs research activity and epidemiological indicators across World Health Organization (WHO) regions from 2000\u20132024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using this pipeline, we linked 1,07,251 NTDrelated publications to 23 disease-specific indicators from WHO, World Bank, and Our World in Data databases. Region-year panels were analyzed using bivariate regressions and hierarchical mixed-eects models, with publication count as the predictor and disease indicators as dependent variables, adjusting for temporal trends and regional clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher research activity was significantly associated with reductions in HIV incidence, tuberculosis incidence, malaria incidence, and schistosomiasis treatment requirements, with hierarchical models confirming consistent protective associations and moderate heterogeneity across regions. In contrast, indicators such as antibiotic consumption and total DALYs showed incoherent or null relationships, suggesting persistent misalignment between research intensity and broader health indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>By introducing a reproducible, data-driven framework for assessing research-indicators coherence, this study shows that although NTDs research contributes to epidemiological improvements, coherence remains incomplete. Incorporating coherence metrics into global health assessment may help align scientific investment with public health needs and enhance the translational impact of research systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frma.2026.1766718","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:30:34Z","timestamp":1781760634000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Measuring scientific coherence between global neglected tropical disease research and population health indicators: a 25-year meta-research study"],"prefix":"10.3389","volume":"11","author":[{"given":"David A.","family":"Hernandez-Paez","sequence":"first","affiliation":[{"name":"Center for Meta-Research and Scientometrics in Biomedical Sciences","place":["Barranquilla, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Fernando","family":"Montoya-Quintero","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias para la Salud, Universidad de Manizales","place":["Manizales, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhon V\u00edctor","family":"Vidal-Durango","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias B\u00e1sicas, Universidad de C\u00f3rdoba","place":["Monter\u00eda, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan David","family":"Lozada-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Center for Meta-Research and Scientometrics in Biomedical Sciences","place":["Barranquilla, Colombia"]},{"name":"Biomedical Scientometrics and Evidence-Based Research Unit, Department of Health Sciences, Universidad de la Costa","place":["Barranquilla, Colombia"]},{"name":"Cl\u00ednica Iberoam\u00e9rica, Cl\u00ednica Colsanitas S.A.","place":["Barranquilla, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev-publhealth-060922-034822","article-title":"Challenges and opportunities for paving the road to global health equity through implementation science","volume":"45","author":"Adsul","year":"2024","journal-title":"Annu Rev Public Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12874-025-02524-2","article-title":"Building a synthesis-ready research ecosystem: fostering collaboration and open science to accelerate biomedical translation","volume":"25","author":"Bannach-Brown","year":"2025","journal-title":"BMC Med. 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