{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:00:14Z","timestamp":1785150014178,"version":"3.55.0"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiomes"],"abstract":"<jats:p>\n                    Obesity affects over one billion people globally; however, the role of the gut microbiome and host genetics in its manifestation is poorly understood. We demonstrate that genetic obesity in leptin-receptor-deficient db\/db mice requires a permissive gut microbiome, which is established during early life. Using perinatally-administered antibiotic cocktail treatment until pups were 8-weeks-old, we demonstrate that microbiome perturbation substantially reduces weight gain and significantly reduces hyperglycemia in homozygous, leptin-receptor-deficient db\/db (Hom) mice without altering caloric intake or extraction efficiency. 16S rRNA sequencing revealed that antibiotic treatment depletes\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    while enriching\n                    <jats:italic>Akkermansiaceae<\/jats:italic>\n                    and\n                    <jats:italic>Bacteroidaceae<\/jats:italic>\n                    . Differential abundance analysis identified\n                    <jats:italic>Duncaniella muris<\/jats:italic>\n                    , a recently characterized\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    species, as the most depleted taxon in antibiotic-treated mice. Oral gavage of cultured\n                    <jats:italic>D. muris<\/jats:italic>\n                    into antibiotic-treated db\/db mice restored hyperglycemia to pre-treatment levels without affecting body weight, establishing a direct causal link between this specific microbe and glucose increase. These findings reveal that hyperglycemia is not solely genetic, but depends critically on specific microbiota members in a permissive microbial context.\n                  <\/jats:p>","DOI":"10.3389\/frmbi.2026.1750320","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:10:30Z","timestamp":1785147030000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perinatal antibiotics in a db\/db mouse model impact obesity and hyperglycemia in a microbiome-dependent manner"],"prefix":"10.3389","volume":"5","author":[{"given":"Noelle","family":"Curtis-Joseph","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University","place":["Providence, RI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra","family":"Laubi","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University","place":["Providence, RI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ortiz-Alvarez de la Campa","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University","place":["Providence, RI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Belenky","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University","place":["Providence, RI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.795333","article-title":"Vancomycin-induced modulation of Gram-positive gut bacteria and metabolites remediates insulin resistance in iNOS knockout mice","volume":"11","author":"Aggarwal","year":"2022","journal-title":"Front. 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