{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:08:54Z","timestamp":1757542134513,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral. Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Report of the incidence of malignant hematologic neoplasms in the oral cavity according to the experience of the two oral and maxillofacial pathology institutions in North Carolina, USA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10-year retrospective review was carried out in the records of patients at ECU SoDM and UNC Adams SoD. Age, sex, location of the lesion, clinical impression, initial diagnosis, and the expression immunohistochemical and molecular markers were recorded for each subject. All diagnoses were reviewed according to the 2016 revision of the WHO classification of lymphoid neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 318 records from both institutions were reviewed. Seventy males and 68 females with an average age of 60.7 comprised the study population. The most common neoplasm encountered was plasma cell myeloma, followed by diffuse large B-cell lymphoma, B-lymphoblastic lymphoma, and follicular lymphoma. We encountered primarily intraosseous tumors, with the posterior mandible and posterior maxilla being the most common locations. Twelve cases were identified initially as a periapical radiolucency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings are concurrent with the existing literature regarding epidemiologic data. However, the type and location of tumors encountered do not, as the most common lymphoma in the oral cavity is diffuse large B-cell lymphoma, typically present in soft tissue. To aid in diagnosis and treatment, the collection of data should continue over time so that eventually, a more specific diagnostic profile of North Carolina residents with these neoplasms can be made.<\/jats:p><\/jats:sec>","DOI":"10.3389\/froh.2022.802555","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T05:03:04Z","timestamp":1643864584000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Malignant Lymphoproliferative Disorders of the Oral and Maxillofacial Region: Report of Two Institutions"],"prefix":"10.3389","volume":"3","author":[{"given":"Andres","family":"Flores-Hidalgo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alec","family":"Bankhead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Murrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"volume-title":"Cancer Facts & Figure 2020","year":"2020","author":"Society","key":"B1"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the world health organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.7150\/ijms.10483","article-title":"Malignant lymphomas in the head and neck region-a retrospective, single-center study over 41 years","volume":"12","author":"Walter","year":"2015","journal-title":"Int J Med Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.5114\/wo.2017.66659","article-title":"Head and neck lymphomas - a retrospective ten-year observation","volume":"21","author":"Niemiec","year":"2017","journal-title":"Contemp Oncol."},{"key":"B5","unstructured":"Oral Manifestations Of Lymphoma: A Systematic Review\n            DominguesT\n            SilvaB\n            BeloC\n            FerreiraT\n            LeiteGB\n            Roberto De Menezes PontesJ\n          275949102016"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1016\/j.joms.2012.01.018","article-title":"Extranodal non-hodgkin lymphomas of the oral cavity and maxillofacial region: a clinical study of 58 cases and review of the literature","volume":"70","author":"Triantafillidou","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/S0140-6736(12)60605-9","article-title":"Non-hodgkin lymphoma","volume":"380","author":"Shankland","year":"2012","journal-title":"Lancet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e619","DOI":"10.4317\/medoral.18903","article-title":"Malignant lymphoma of the oral cavity and the maxillofacial region: Overall survival prognostic factors","volume":"18","author":"Guevara-Canales","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal."},{"key":"B9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.amjoto.2014.10.008","article-title":"Extra-nodal B-cell non-hodgkin's lymphomas of the head and neck: a study of 68 cases","volume":"36","author":"Bagan J","year":"2015","journal-title":"Am J Otolaryngol."}],"container-title":["Frontiers in Oral Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2022.802555\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T05:03:06Z","timestamp":1643864586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2022.802555\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":9,"alternative-id":["10.3389\/froh.2022.802555"],"URL":"https:\/\/doi.org\/10.3389\/froh.2022.802555","relation":{},"ISSN":["2673-4842"],"issn-type":[{"type":"electronic","value":"2673-4842"}],"subject":[],"published":{"date-parts":[[2022,2,3]]},"article-number":"802555"}}