{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:28:40Z","timestamp":1787027320045,"version":"build-2736575974"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral. Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiotherapy and chemotherapy are frequently employed in head and neck cancer (HNC) patients causing significant side effects that impair life quality and prognosis. Photobiomodulation (PBM) has become a growing approach to managing such oral complications. Despite its proven efficacy and absence of contraindications, there is still a lack of universally accepted disease-specific PBM protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A narrative review was conducted to identify the current proposals relating to the use of PBM to treat complications of oncological treatments in HNC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An electronic search in PubMed and Scopus databases was performed with the following keywords: (\u201cphotobiomodulation\u201d OR \u201cPBM\u201d OR \u201claser therapy\u201d OR \u201cLLLT\u201d OR \u201claser\u201d) AND (\u201chead and neck cancer\u201d OR \u201coral cancer\u201d) AND (\u201cmucositis\u201d OR \u201coral mucositis\u201d OR \u201cdysgeusia\u201d OR \u201coedema\u201d OR \u201cxerostomia\u201d OR \u201cdermatitis\u201d OR \u201ctrismus\u201d) until October 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 35 papers were included in the narrative review. Oral mucositis was the most studied complication, and advisable protocols are conceivable. Although there is a growing interest in PBM to manage of xerostomia, radiodermatitis, pain, and trismus, literature is still scarce to propose a universally feasible protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PBM therapy could significantly prevent or reduce the severity of many side effects related to cancer therapies. More research is needed to obtain recommendations over the preferable parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/froh.2022.945718","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T01:57:02Z","timestamp":1657159022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Quality Assessment of PBM Protocols for Oral Complications in Head and Neck Cancer Patients: Part 1"],"prefix":"10.3389","volume":"3","author":[{"given":"Margherita","family":"Gobbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Merigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen R.","family":"Arany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9-Jean","family":"Bensadoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Roger","family":"Santos-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alcino","family":"Gueiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.canrad.2021.02.001","article-title":"Early side effects of radiation treatment for head and neck cancer","volume":"25","author":"Brook","year":"2021","journal-title":"Cancer Radiother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"10581","DOI":"10.1038\/srep10581","article-title":"Molecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stress","volume":"5","author":"Khan","year":"2015","journal-title":"Sci Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1177\/0022034516648939","article-title":"Craniofacial wound healing with photobiomodulation therapy: new insights and current challenges","volume":"95","author":"Arany","year":"2016","journal-title":"J Dent Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"CD000978","DOI":"10.1002\/14651858.CD000978.pub4","article-title":"Interventions for preventing oral mucositis for patients with cancer receiving treatment","volume":"2011","author":"Worthington","year":"2011","journal-title":"Cochrane Database Syst Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s005200050256","article-title":"Low-energy He\/Ne laser in the prevention of radiation-induced mucositis. 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