{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:07:24Z","timestamp":1790014044900,"version":"4.0.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral. Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oral infectious diseases are common chronic oral diseases characterized by a chronic inflammatory condition. We investigated chronic oral diseases as potential risk factors for systemic chronic diseases, diabetes mellitus, connective tissue diseases, seropositive rheumatoid arthritis, ulcerative colitis, and Crohn's disease, as well as severe psychotic and other severe mental disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cohort comprised 68,273 patients aged \u2265 29 years with at least one dental visit to the Helsinki City Health Services between 2001 and 2002. The cohort was linked to the data on death (Statistics Finland), cancer (Finnish Cancer Registry), and drug reimbursement (Finnish Social Insurance Institution) and followed until death or the end of 2013. The outcomes of interest were the incidences of chronic diseases measured starting with special refund medication, which means Social Insurance Institution partly or fully reimburses medication costs. Outcomes of interest were diabetes mellitus, connective tissue diseases, seropositive rheumatoid arthritis, ulcerative colitis and Crohn's disease, and severe mental disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean follow-up time was 9.8 years. About 25% of the study population had periodontitis, 17% caries, over 70% apical periodontitis, and 9% &amp;lt;24 teeth at the start of follow-up. Diabetes was the only chronic systemic condition associated with oral health variables. Having 24 to 27 teeth was associated with a higher incidence rate ratio (IRR) (1.21, 95% confidence interval 1.09\u20131.33) compared to having 28 or more teeth; the IRR for having 23 or less was 1.40 (1.22\u20131.60). Having periodontitis (1.10, 1.01\u20131.20), caries (1.12, 1.01\u20131.23), or apical periodontitis (1.16, 1.04\u20131.30) is also associated with a higher risk of diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our epidemiological 10 years follow-up study suggests that the association exists between chronic oral diseases and diabetes, warranting close collaboration among patient's healthcare professionals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/froh.2022.956072","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T01:26:12Z","timestamp":1660785972000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Oral health associated with incident diabetes but not other chronic diseases: A register-based cohort study"],"prefix":"10.3389","volume":"3","author":[{"given":"Pia","family":"Heikkil\u00e4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"But","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Haukka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1159\/000488948","article-title":"Caries and periodontitis: contesting the conventional wisdom on their aetiology","volume":"52","author":"Manji","year":"2018","journal-title":"Caries Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S135","DOI":"10.1902\/jop.2013.1340013","article-title":"Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence","volume":"84","author":"Borgnakke","year":"2013","journal-title":"J Periodontol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/jcpe.12698","article-title":"Inflammatory bowel disease and oral health: systematic review and a meta-analysis","volume":"44","author":"Papageorgiou Spyridon","year":"2017","journal-title":"J Clin Periodontol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.17980\/2016.200","article-title":"Chronic inflammation and carcinogenesis \u2013 emerging role of chronic inflammatory periodontal disease","volume":"2","author":"Grover","year":"2016","journal-title":"Cancer Res Front."},{"key":"B5","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1161\/01.CIR.0000154582.37101.15","article-title":"Periodontal microbiota and carotid intima-media thickness: the oral infections and vascular disease epidemiology study (INVEST)","volume":"111","author":"Desvarieux","year":"2005","journal-title":"Circulation."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1161\/CIR.0b013e31825719f3","article-title":"Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? 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