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Emergent properties of these communities are driven to a large extent by interspecies communication which can be based on physical association, secreted small molecules or nutritional exchange. <jats:italic>Porphyromonas gingivalis<\/jats:italic> is a consensus periodontal pathogen; however, virulence is only expressed in the context of a polymicrobial community. Multivalent fimbriae mediate attachment to other oral species which can initiate a distinct transcriptional program in both constituents of the binding pair. <jats:italic>P. gingivalis<\/jats:italic> also responds to small molecules and nutritional cues produced by partner organisms. Physiological interdependence forms the basis of complex networks of cooperating organisms which begin to resemble an organismal entity exhibiting a spectrum of pathogenic potential.<\/jats:p>","DOI":"10.3389\/froh.2024.1404917","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T09:53:00Z","timestamp":1714125180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["The polymicrobial pathogenicity of Porphyromonas gingivalis"],"prefix":"10.3389","volume":"5","author":[{"given":"Richard 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