{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:27:42Z","timestamp":1788053262446,"version":"build-2784847793"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral. Health"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Recurrence and survival in early T-stage oral tongue squamous cell carcinoma (OTSCC) may be impacted by histopathologic risk factors. This study aims to examine which of these factors predict long-term outcomes of T1 and T2 OTSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of T1 and T2 OTSCC patients treated with surgery at a single tertiary care center was conducted. Multivariate regression and Kaplan-Meier survival plots were used to identify predictors of recurrence and compare disease-free survival respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      100 consecutive patients were studied. Of these, 51 were staged pT1, 49 pT2, 69 pN0, 10 pN1, and 21 pN2. Multivariate regression analysis revealed that &amp;gt;4 nodes was the strongest predictor of overall recurrence [odds ratio 1.68 (1.23\u20132.28),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001], while &amp;gt;4 nodes [odds ratio 1.14 (1.09\u20131.85),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008] and pT2 [odds ratio 1.15 (1.01\u20131.30),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033] were predictors of local recurrence (R2\u2009=\u20090.112). Five-year disease-free survival was not significantly impacted by any risk factors except for the number of positive nodes\u201486% for \u22644 nodes vs. 20% for &amp;gt;4 nodes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001)\u2014and pathologic T-stage\u201490% for pT1 vs. 75% for pT2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035) regardless of adjuvant radiation and\/or chemotherapy use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients who underwent adjuvant radiation and\/or chemotherapy had similar survival to those who did not despite having worse overall tumor prognostic factors. Adding adjuvant therapy may equalize some high-risk histopathologic factors. In the highest risk patients\u2014specifically those with pathologic &amp;gt;4 nodes and pT2 staging\u2014adjuvant therapy should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/froh.2024.1426709","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:08:43Z","timestamp":1722910123000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Histopathologic predictors of recurrence and survival in early T stage oral tongue squamous cell carcinoma"],"prefix":"10.3389","volume":"5","author":[{"given":"Benjamin J.","family":"Damazo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal A.","family":"Punjabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan 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