{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:31:24Z","timestamp":1753893084322,"version":"3.41.2"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral. Health"],"abstract":"<jats:p>Physicians are increasingly prescribing antifungal drugs empirically to treat hospital-acquired infections quickly. This makes it obvious that fungal infections require more attention and systematic monitoring of resistance among them. The aim of the study was to identify antifungal drugs that retain their efficacy against <jats:italic>C. albicans<\/jats:italic> isolates. There were 17 clinical isolates of <jats:italic>Candida albicans<\/jats:italic> obtained from patients and tested for susceptibility to antifungal drugs using the standard double dilution method. Amphotericin B, fluconazole, itraconazole, micafungin, and posaconazole were used in the study. To determine the groups of antimycotics to which the studied microorganisms retain sensitivity, a hierarchical cluster analysis was performed using the Ward's method. The tested representatives of the genus <jats:italic>Candida<\/jats:italic> showed the lowest sensitivity to fluconazole. The efficacy of amphotericin B and itraconazole was almost at the same level. In turn, micafungin and posaconazole showed the best results against <jats:italic>C. albicans isolates<\/jats:italic>. Ward's cluster analysis combined the results of <jats:italic>C. albicans<\/jats:italic> susceptibility to fluconazole, micafungin and itraconazole by the highest mathematical similarity. Amphotericin B and posaconazole were combined into one cluster due to their better efficacy against <jats:italic>Candida albicans<\/jats:italic> isolates.<\/jats:p>","DOI":"10.3389\/froh.2024.1446045","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:10:52Z","timestamp":1725599452000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cluster analysis allowed to identify antifungal drugs that retain efficacy against Candida albicans isolated from patients with inflammatory diseases of the soft tissues of the maxillofacial area"],"prefix":"10.3389","volume":"5","author":[{"given":"Mariia","family":"Faustova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr","family":"Dobrovolskyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Loban\u2019","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevhenii","family":"Bereza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Kotelnikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Dobrovolskyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/bs.aambs.2014.12.002","article-title":"Candida survival strategies","volume":"91","author":"Polke","year":"2015","journal-title":"Adv Appl Microbiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1080\/21505594.2022.2123325","article-title":"Distribution and antifungal susceptibility pattern of Candida species from mainland China: a systematic analysis","volume":"13","author":"Bilal","year":"2022","journal-title":"Virulence"},{"key":"B3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.17116\/otorino20198403174","article-title":"Opportunistic fungal infections of ent organs. 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