{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T11:22:17Z","timestamp":1768648937479,"version":"3.49.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFS0634"],"award-info":[{"award-number":["2022YFS0634"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFS0634-C2"],"award-info":[{"award-number":["2022YFS0634-C2"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022-SYF-33"],"award-info":[{"award-number":["2022-SYF-33"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2022ZD015"],"award-info":[{"award-number":["2022ZD015"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Affiliated Stomatological Hospital of Southwest Medical University","award":["2022Z01"],"award-info":[{"award-number":["2022Z01"]}]},{"name":"Foundation Project of Sichuan Medical Association","award":["S21063"],"award-info":[{"award-number":["S21063"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tissue repair can be promoted by moderate inflammation but suppressed by excessive levels. Therefore, control of excessive inflammation following removal of infection plays a critical role in promotion of pulpal repair. Connexin 43 (Cx43) forms hemichannels (HCs) or gap channels (GJs) to facilitate the delivery of small molecules between cells to regulate both inflammation and repair. Understanding the role of Cx43 in dental pulp may help develop a potential strategy to attenuate the inflammation and promote the formation of reparative dentin in deep caries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We firstly investigated the expression profile of Cx43 in infected human third molars by histological analysis; then, we detected channel activity of Cx43 and the effect of mediating release of small molecules in lipopolysaccharide (LPS)-induced inflammation in human dental pulp cells (hDPCs) by molecular biology methods. Results were analyzed by one-way ANOVA and the unpaired <jats:italic>t<\/jats:italic>-test. The level of significance was set at <jats:italic>\u03b1<\/jats:italic>\u2009=\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis showed that the expression of Cx43 was upregulated in human third molars as the degree of infection increased, and Cx43 was not only expressed in odontoblast layer, but also detected in cell-rich zone and pulp proper. LPS activated Cx43 HCs in hDPCs while inhibiting GJs; blockade of Cx43 HCs attenuated LPS-induced inflammation. Furthermore, LPS promoted the extracellular release of adenosine triphosphate (ATP) and high-mobility group box 1 (HMGB1) within hDPCs, thus exacerbating LPS-induced inflammation. The blockade of Cx43 HCs inhibited the extracellular release of ATP and HMGB1 within hDPCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, our finding suggested that Cx43 plays a key role in infection and inflammation in dental pulp. LPS activates Cx43 HCs to mediate the extracellular release of ATP and HMGB1 to exacerbate LPS-induced inflammation of hDPCs.<\/jats:p><\/jats:sec>","DOI":"10.3389\/froh.2024.1496819","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:10:30Z","timestamp":1733098230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1"],"prefix":"10.3389","volume":"5","author":[{"given":"Peiling","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanpei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jdsr.2018.03.001","article-title":"The roles of odontoblasts in dental pulp innate immunity","volume":"54","author":"Yumoto","year":"2018","journal-title":"Jpn Dent Sci Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1399-302X.2007.00310.x","article-title":"Differential regulation of immune responses by odontoblasts","volume":"22","author":"Veerayutthwilai","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.3390\/ijms22031480","article-title":"Inflammatory response mechanisms of the dentine-pulp complex and the periapical tissues","volume":"22","author":"Galler","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1016\/j.joen.2014.01.020","article-title":"Mobilized dental pulp stem cells for pulp regeneration: initiation of clinical trial","volume":"40","author":"Nakashima","year":"2014","journal-title":"J Endod"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.4049\/jimmunol.176.5.2880","article-title":"Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts","volume":"176","author":"Durand","year":"2006","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"154896","DOI":"10.1016\/j.cyto.2019.154896","article-title":"Role(s) of cytokines in pulpitis: latest evidence and therapeutic approaches","volume":"126","author":"Khorasani","year":"2020","journal-title":"Cytokine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.jdent.2010.05.016","article-title":"Inflammation-regeneration interplay in the dentine-pulp complex","volume":"38","author":"Cooper","year":"2010","journal-title":"J Dent"},{"key":"B8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2172-12-9","article-title":"Caries induced cytokine network in the odontoblast layer of human teeth","volume":"12","author":"Horst","year":"2011","journal-title":"BMC Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.joen.2014.01.031","article-title":"EZH2, a potential regulator of dental pulp inflammation and regeneration","volume":"40","author":"Hui","year":"2014","journal-title":"J Endod"},{"key":"B10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1089\/dna.2024.0044","article-title":"Immune system of dental pulp in inflamed and normal tissue","volume":"43","author":"Sarfi","year":"2024","journal-title":"DNA Cell Biol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s41232-016-0020-7","article-title":"Inflammatory responses in the initiation of lung repair and regeneration: their role in stimulating lung resident stem cells","volume":"36","author":"Yamada","year":"2016","journal-title":"Inflamm Regen"},{"key":"B12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.joen.2018.10.009","article-title":"The effects of mitogen-activated protein kinase signaling pathways on lipopolysaccharide-mediated osteo\/odontogenic differentiation of stem cells from the apical papilla","volume":"45","author":"Liu","year":"2019","journal-title":"J Endod"},{"key":"B13","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/jcp.24732","article-title":"LPS promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway","volume":"230","author":"He","year":"2015","journal-title":"J Cell Physiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1042\/BJ20082319","article-title":"Connexin43 phosphorylation: structural changes and biological effects","volume":"419","author":"Solan","year":"2009","journal-title":"Biochem J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.yjmcc.2009.03.016","article-title":"Cardiac cell-cell junctions in health and disease: electrical versus mechanical coupling","volume":"47","author":"Noorman","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1242\/jcs.200667","article-title":"Role of connexin 43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes","volume":"130","author":"Ribeiro-Rodrigues","year":"2017","journal-title":"J Cell Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.semcdb.2015.12.017","article-title":"Connexins in the skeleton","volume":"50","author":"Stains","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.molmed.2018.10.005","article-title":"Therapeutic targeting of connexin channels: new views and challenges","volume":"24","author":"Delvaeye","year":"2018","journal-title":"Trends Mol Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311955","article-title":"GJA1-20k arranges actin to guide Cx43 delivery to cardiac intercalated discs","volume":"121","author":"Basheer","year":"2017","journal-title":"Circ Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/nrd.2018.138","article-title":"Therapeutic strategies targeting connexins","volume":"17","author":"Laird","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"B21","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/10409238.2016.1204980","article-title":"Connexins and their channels in inflammation","volume":"51","author":"Willebrords","year":"2016","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"eadg1668","DOI":"10.1126\/scisignal.adg1668","article-title":"Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors","volume":"16","author":"Morales-Soto","year":"2023","journal-title":"Sci Signal"},{"key":"B23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s12974-020-01978-z","article-title":"Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling","volume":"17","author":"Yu","year":"2020","journal-title":"J Neuroinflammation"},{"key":"B24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s004290100166","article-title":"Expression and localization of connexin 43 in rat incisor odontoblasts","volume":"203","author":"Murakami","year":"2001","journal-title":"Anat Embryol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1080\/03008200290000952","article-title":"In vivo and in vitro expression of connexin 43 in human teeth","volume":"43","author":"About","year":"2002","journal-title":"Connect Tissue Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/0022034513478430","article-title":"Odontoblastic syncytium through electrical coupling in the human dental pulp","volume":"92","author":"Ikeda","year":"2013","journal-title":"J Dent Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41368-020-00105-1","article-title":"Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair","volume":"13","author":"Yin","year":"2021","journal-title":"Int J Oral Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yexcr.2015.09.008","article-title":"Connexin43-containing gap junctions potentiate extracellular Ca(2)(+)-induced odontoblastic differentiation of human dental pulp stem cells via Erk1\/2","volume":"338","author":"Li","year":"2015","journal-title":"Exp Cell Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s00784-020-03439-6","article-title":"Pulpal upregulation of connexin 43 during pulpitis","volume":"25","author":"Lim","year":"2021","journal-title":"Clin Oral Investig"},{"key":"B30","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/0022034514539507","article-title":"Reactionary dentinogenesis and neuroimmune response in dental caries","volume":"93","author":"Couve","year":"2014","journal-title":"J Dent Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00441-005-0117-9","article-title":"In vitro characterization of human dental pulp cells: various isolation methods and culturing environments","volume":"324","author":"Huang","year":"2006","journal-title":"Cell Tissue Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3390\/biology11020237","article-title":"The role of connexin hemichannels in inflammatory diseases","volume":"11","author":"Peng","year":"2022","journal-title":"Biology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"7340","DOI":"10.3390\/ijms21197340","article-title":"Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating","volume":"21","author":"Lissoni","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.joen.2018.02.022","article-title":"Human dental pulp cells express cellular markers for inflammation and hard tissue formation in response to bacterial information","volume":"44","author":"Sugiuchi","year":"2018","journal-title":"J Endod"},{"key":"B35","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ceb.2007.09.001","article-title":"Gap junction channel structure in the early 21st century: facts and fantasies","volume":"19","author":"Yeager","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-associated molecular patterns in inflammatory diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3390\/ijms19041222","article-title":"Mechanisms of ATP release by inflammatory cells","volume":"19","author":"Dosch","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1080\/14728222.2019.1673368","article-title":"Targeting connexin hemichannels to control the inflammasome: the correlation between connexin43 and NLRP3 expression in chronic eye disease","volume":"23","author":"Mugisho","year":"2019","journal-title":"Expert Opin Ther Targets"},{"key":"B39","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.bbagen.2017.11.015","article-title":"The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release","volume":"1862","author":"Mugisho","year":"2018","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"B40","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s12964-023-01245-7","article-title":"Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury","volume":"21","author":"Roger","year":"2023","journal-title":"Cell Commun Signal"},{"key":"B41","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2119\/2008-00034.Klune","article-title":"HMGB1: endogenous danger signaling","volume":"14","author":"Klune","year":"2008","journal-title":"Mol Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.pharmthera.2015.06.005","article-title":"Connexin 43 is an emerging therapeutic target in ischemia\/reperfusion injury, cardioprotection and neuroprotection","volume":"153","author":"Schulz","year":"2015","journal-title":"Pharmacol Ther"},{"key":"B43","doi-asserted-by":"publisher","first-page":"13781","DOI":"10.1523\/JNEUROSCI.2042-07.2007","article-title":"Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia","volume":"27","author":"Retamal","year":"2007","journal-title":"J Neurosci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fncel.2014.00122","article-title":"Regulation of gap junction channels by infectious agents and inflammation in the CNS","volume":"8","author":"Castellano","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e12125","DOI":"10.1097\/MD.0000000000012125","article-title":"Effect of gap junctions on RAW264.7 macrophages infected with H37Rv","volume":"97","author":"Lu","year":"2018","journal-title":"Medicine"},{"key":"B46","doi-asserted-by":"publisher","first-page":"6186","DOI":"10.3390\/ijms20246186","article-title":"Connexin 43 mutations lead to increased hemichannel functionality in skin disease","volume":"20","author":"Cocozzelli","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3389\/fncel.2018.00372","article-title":"Inhibition of connexin 43 hemichannels alleviates cerebral ischemia\/reperfusion injury via the TLR4 signaling pathway","volume":"12","author":"Chen","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12964-020-00558-1","article-title":"Blocking connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease","volume":"18","author":"Price","year":"2020","journal-title":"Cell Commun Signal"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e12585","DOI":"10.1111\/micc.12585","article-title":"Inflammation-the role of ATP in pre-eclampsia","volume":"27","author":"Fodor","year":"2020","journal-title":"Microcirculation"},{"key":"B50","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3389\/fnins.2016.00311","article-title":"Purinergic signaling in gut inflammation: the role of connexins and pannexins","volume":"10","author":"Diezmos","year":"2016","journal-title":"Front Neurosci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","article-title":"The P2X7 receptor: a main player in inflammation","volume":"151","author":"Adinolfi","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"114205","DOI":"10.1016\/j.biopha.2022.114205","article-title":"ATP ion channel P2X purinergic receptors in inflammation response","volume":"158","author":"Liu","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1161\/01.RES.0000250174.31269.70","article-title":"ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function","volume":"99","author":"Eltzschig","year":"2006","journal-title":"Circ Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1523\/JNEUROSCI.5048-07.2008","article-title":"Connexin 43 hemichannels are permeable to ATP","volume":"28","author":"Kang","year":"2008","journal-title":"J Neurosci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40659-023-00468-9","article-title":"SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca(2+) dynamics","volume":"56","author":"Prieto-Villalobos","year":"2023","journal-title":"Biol Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.3389\/fimmu.2018.01899","article-title":"Connexin 43 hemichannel activity promoted by pro-inflammatory cytokines and high glucose alters endothelial cell function","volume":"9","author":"Saez","year":"2018","journal-title":"Front Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1523\/JNEUROSCI.1216-11.2012","article-title":"Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury","volume":"32","author":"Huang","year":"2012","journal-title":"J Neurosci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3389\/fimmu.2020.00484","article-title":"Targeting inflammation driven by HMGB1","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"107497","DOI":"10.1016\/j.intimp.2021.107497","article-title":"NUTM2A-AS1 silencing alleviates LPS-induced apoptosis and inflammation in dental pulp cells through targeting let-7c-5p\/HMGB1 axis","volume":"96","author":"Wang","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.bbrc.2014.07.027","article-title":"Expression of high mobility group box 1 in inflamed dental pulp and its chemotactic effect on dental pulp cells","volume":"450","author":"Zhang","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"B61","doi-asserted-by":"publisher","first-page":"754069","DOI":"10.1155\/2014\/754069","article-title":"Overexpression of receptor for advanced glycation end products and high-mobility group box 1 in human dental pulp inflammation","volume":"2014","author":"Tancharoen","year":"2014","journal-title":"Mediators Inflamm"},{"key":"B62","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2119\/molmed.2013.00064","article-title":"Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release","volume":"19","author":"Li","year":"2013","journal-title":"Mol Med"}],"updated-by":[{"DOI":"10.3389\/froh.2025.1687229","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000}}],"container-title":["Frontiers in Oral Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2024.1496819\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:39:32Z","timestamp":1759847972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2024.1496819\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":62,"alternative-id":["10.3389\/froh.2024.1496819"],"URL":"https:\/\/doi.org\/10.3389\/froh.2024.1496819","relation":{},"ISSN":["2673-4842"],"issn-type":[{"value":"2673-4842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"article-number":"1496819"}}