{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:31:34Z","timestamp":1753893094983,"version":"3.41.2"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The kidney, brain, and endocrine glands all express calbindin-D28K, a calcium-binding protein that is essential for maintaining calcium homeostasis. Calcium metabolism is disturbed in chronic kidney disease (CKD), which may have an impact on dental and bone health. Patients on dialysis frequently have changed salivary composition, which raises their risk of dental problems such tooth decay and periodontal disease. Although there is no direct study on the relationship between Calbindin-D28K and dental health in dialysis patients, its function in calcium control raises the possibility of a connection that merits more investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To address the impact of Calbindin-D28K levels in chronic kidney disease on oral health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A comprehensive electronic search was conducted using databases like PubMed, ResearchGate, SCOPUS, and others, to find relevant articles published before May 2024. The search terms included Calbindin-D28K, renal dialysis, dental and oral health, Vitamin D, calcium, end-stage renal disease, and related topics. The review examined studies from 1975 to 2024, focusing on the relationship between dental health and renal dialysis and factors affecting Calbindin-D28K levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48 articles were retrieved through electronic database. After evaluating the title, abstract, and full text of these articles, only 7 were selected for the present review. Final consideration: Based on the data available on selected studies, they point to a possible association between these people's higher frequency of periodontal disease and tooth caries and lower levels of Calbindin-D28K.It is imperative to recognize the reciprocal impact of systemic illnesses on oral health. In addition to being important for maintaining calcium homeostasis, calbindin-D28K may also be a biomarker for renal damage and have an impact on dental health. Its relevance for both diagnosis and treatment of chronic kidney disease and associated diseases is highlighted by its involvement in renal function and neuroprotection.<\/jats:p><\/jats:sec>","DOI":"10.3389\/froh.2025.1523024","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T05:25:10Z","timestamp":1745558710000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the association of calbindin \u2013D28K in renal dialysis with oral health: a comprehensive review"],"prefix":"10.3389","volume":"6","author":[{"given":"Mohamed","family":"Jaber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Saleh Hamad","family":"Ingafou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nireeksha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Maniangat Luke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5196285","DOI":"10.1155\/2018\/5196285","article-title":"Projecting the burden of chronic kidney disease in a developed country and its implications on public health","volume":"2018","author":"Wong","year":"2018","journal-title":"Int J Nephrol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2011","journal-title":"Kidney Int Suppl"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3390\/ijerph20021298","article-title":"Chronic kidney disease and periodontitis interplay-A narrative review","volume":"20","author":"Baciu","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3390\/healthcare10020406","article-title":"Oral hygiene practices and oral health knowledge among students in split, Croatia","volume":"10","author":"Tadin","year":"2022","journal-title":"Healthcare"},{"key":"B5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.2215\/CJN.05470610","article-title":"Systemic consequences of poor oral health in chronic kidney disease patients","volume":"6","author":"Akar","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"B6","article-title":"Chronic kidney disease","volume-title":"StatPearls","author":"Vaidya","year":"2024"},{"key":"B7","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1902\/jop.2005.76.4.558","article-title":"Risk indicators of periodontal disease in older Thai adults","volume":"76","author":"Torrungruang","year":"2005","journal-title":"J Periodontol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"9610892","DOI":"10.1155\/2018\/9610892","article-title":"Dental care for patients with end-stage renal disease and undergoing hemodialysis","volume":"2018","author":"Costantinides","year":"2018","journal-title":"Int J Dent"},{"key":"B9","first-page":"e211","article-title":"Is there association between chronic kidney disease and dental caries? A case-controlled study","volume":"24","author":"Menezes","year":"2019","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"B10","first-page":"171","article-title":"Stan uz\u0119bienia i leczenia protetycznego u pacjent\u00f3w z przewlek\u0142\u0105 chorob\u0105 nerek leczonych hemodializami","volume":"12","author":"Baranowicz-G\u0105szczyk","year":"2008","journal-title":"Analiza przyczyn ograniczonego zaopatrzenia protetycznego Nefrol Dial Pol"},{"key":"B11","first-page":"20","article-title":"DNP, CNN-NP, FNP-bc, APRNKidney disease & \u201cbad teeth\u201d","volume":"26","author":"Smith","year":"2016","journal-title":"Clinician Reviews"},{"key":"B12","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3390\/ijerph20010835","article-title":"Oral Mucosa status in patients with end-stage chronic kidney disease undergoing hemodialysis","volume":"20","author":"Dembowska","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"701","DOI":"10.2174\/1874210601711010701","article-title":"Relationship between periodontal disease and serum factors in patients undergoing hemodialysis","volume":"11","author":"Naghsh","year":"2017","journal-title":"Open Dent J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/ndt\/gfl676","article-title":"The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients","volume":"22","author":"Borawski","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"B15","first-page":"1","article-title":"si\u0119 w\u0119chu i smaku u chorych z przewlek\u0142\u0105 niewydolno\u015bci\u0105 nerek leczonych hemodializ\u0105 otolar","volume":"47","author":"Korytowska","year":"1993","journal-title":"Pol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e25037","DOI":"10.1097\/MD.0000000000025037","article-title":"The tongue features associated with chronic kidney disease","volume":"100","author":"Chen","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12903-015-0004-z","article-title":"Oral findings in chronic kidney disease: implications for management in developing countries","volume":"20","author":"Oyetola","year":"2015","journal-title":"BMC Oral Health"},{"key":"B18","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.tripleo.2008.09.018","article-title":"Oral health status of patients with a mild decrease in glomerular filtration rate","volume":"107","author":"Garcez","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"B19","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/S1079-2104(99)70035-1","article-title":"Oral manifestations and salivary flow rate, pH, and buffer capacity in patients with end-stage renal disease undergoing hemodialysis","volume":"88","author":"Kho","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"B20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/chemse\/bjz001","article-title":"Characterizing dysgeusia in hemodialysis patients","volume":"44","author":"Fitzgerald","year":"2019","journal-title":"Chem Senses"},{"key":"B21","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3747\/pdi.2009.00089","article-title":"Does peritoneal dialysis affect halitosis in patients with end-stage renal disease?","volume":"31","author":"Keles","year":"2011","journal-title":"Perit Dial Int"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1007\/s10096-016-2684-y","article-title":"Tongue coating frequency and its colonization by yeasts in chronic kidney disease patients","volume":"35","author":"Pieralisi","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"6720575","DOI":"10.1155\/2016\/6720575","article-title":"Chronic kidney disease induced intestinal mucosal barrier damage associated with intestinal oxidative stress injury","volume":"2016","author":"Yu","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1177\/0022034511423394","article-title":"Periodontitis predicts elevated C-reactive protein levels in chronic kidney disease","volume":"90","author":"Ioannidou","year":"2011","journal-title":"J Dent Re"},{"key":"B25","article-title":"Ca2+-binding proteins","volume-title":"Encyclopedia of Molecular Pharmacology","author":"Heizmann","year":"2021"},{"key":"B26","doi-asserted-by":"publisher","first-page":"6664","DOI":"10.3390\/ijms25126664","article-title":"Exploring the role of vitamin D, vitamin D-dependent proteins, and vitamin D receptor gene variation in lung cancer risk","volume":"25","author":"Ciocarlie","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B27","first-page":"5","article-title":"Regulation of renal calbindin-D28K","volume":"87","author":"Hemmingsen","year":"2000","journal-title":"Pharmacol Toxicol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/00041552-200007000-00004","article-title":"The role of calbindin and 1,25dihydroxyvitamin D3 in the kidney","volume":"9","author":"Sooy","year":"2000","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B29","doi-asserted-by":"publisher","first-page":"F230","DOI":"10.1152\/ajprenal.00057.2015","article-title":"The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics","volume":"310","author":"Lee","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"52406","DOI":"10.1074\/jbc.M405562200","article-title":"Critical role of calbindin-D28k in calcium homeostasis revealed by mice lacking both vitamin D receptor and calbindin-D28k","volume":"279","author":"Zheng","year":"2004","journal-title":"J Biol Chem"},{"key":"B31","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/0005-2795(75)90223-8","article-title":"Isolation and partial characterization of intestinal calcium binding protein from cow, pig, horse, Guinea pig and chick","volume":"393","author":"Fulmer","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"B32","first-page":"412","article-title":"Does calbindin-D28K buffer intracellular free calcium?","volume-title":"Vitamin D: A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28\u2013June 2, 1994","author":"Rhoten","year":"1994"},{"key":"B33","first-page":"93","article-title":"Calbindin D 28\u2005K immunoreactivity in the brain, kidney, heart, gastrointestinal tract and some endocrine glands of mole rat","volume":"6","author":"Girgin","year":"2015","journal-title":"Int J Biopharma"},{"key":"B34","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/nsmb1112","article-title":"Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K","volume":"13","author":"Kojetin","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1038\/cdd.2014.67","article-title":"Crucial role of calbindin-D28k in the pathogenesis of Alzheimer\u2019s disease mouse model","volume":"21","author":"Kook","year":"2014","journal-title":"Cell Death Differ"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4189","DOI":"10.1007\/s10571-023-01405-w","article-title":"Candidate key proteins in tinnitus: a bioinformatic study of synaptic transmission in spiral ganglion neurons","volume":"43","author":"Gross","year":"2023","journal-title":"Cell Mol Neurobiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1159\/000133111","article-title":"The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3\u2014-q22.1 and 16q22\u2014-q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci","volume":"57","author":"Parmentier","year":"1991","journal-title":"Cytogenet Cell Genet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1073\/pnas.87.11.4078","article-title":"Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases","volume":"87","author":"Iacopino","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B39","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1089\/gtmb.2016.0149","article-title":"SNP Rs1805874 of the Calbindin1 gene is associated with Parkinson\u2019s disease in Han Chinese","volume":"20","author":"Yang","year":"2016","journal-title":"Genet Test Mol Biomarkers"},{"key":"B40","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/cells8070660","article-title":"Role of calbindin-D28k in diabetes-associated advanced glycation end-products-induced renal proximal tubule cell injury","volume":"8","author":"Huang","year":"2019","journal-title":"Cells"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e14718","DOI":"10.1371\/journal.pone.0014718","article-title":"The dynamics of Ca2\u2009+\u2009ions within the solvation shell of calbindin D9k","volume":"6","author":"Project","year":"2011","journal-title":"PLoS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3109\/10409238009105467","article-title":"Structure and evolution of calcium-modulated proteins","volume":"8","author":"Kretsinger","year":"1980","journal-title":"Crit Rev Biochem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"13522","DOI":"10.1021\/bi050861q","article-title":"Calbindin D28k EF-hand ligand binding and oligomerization: four high-affinity sites\u2013three modes of action","volume":"44","author":"Cedervall","year":"2005","journal-title":"Biochemistry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e23068","DOI":"10.1002\/jbt.23068","article-title":"Regulation of renal calbindin expression during cisplatin-induced kidney injury","volume":"36","author":"George","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/diseases11010008","article-title":"Proficient novel biomarkers guide early detection of acute kidney injury: a review","volume":"11","author":"Jana","year":"2022","journal-title":"Diseases Dec"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/0970-4388.31981","article-title":"The dental and oral status of children with chronic renal failure","volume":"25","author":"Nakhjavani","year":"2007","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"B47","doi-asserted-by":"publisher","first-page":"673","DOI":"10.14336\/AD.2021.1024","article-title":"Vascular calcification in chronic kidney disease: an update and perspective","volume":"13","author":"Ren","year":"2022","journal-title":"Aging Dis"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e011836","DOI":"10.1136\/bmjopen-2016-011836","article-title":"Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand","volume":"6","author":"Ausavarungnirun","year":"2016","journal-title":"BMJ open"},{"key":"B49","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1601-0825.1995.tb00189.x","article-title":"Turnover in periodontal connective tissues: dynamic homeostasis of cells, collagen and ground substances","volume":"1","author":"Bartold","year":"1995","journal-title":"Oral Dis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3390\/jcm9051285","article-title":"Salivary gland dysfunction, protein glycooxidation and nitrosative stress in children with chronic kidney disease","volume":"9","author":"Maciejczyk","year":"2020","journal-title":"J Clin Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1159\/000357274","article-title":"Effect of periodontal treatment in renal transplant recipients","volume":"23","author":"Pejcic","year":"2014","journal-title":"Med Princ Pract"},{"key":"B52","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/jcpe.13208","article-title":"Status of periodontal health in German patients suffering from chronic kidney disease-data from the GCKD study","volume":"47","author":"Dannewitz","year":"2020","journal-title":"J Clin Periodontol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1177\/32.2.6363518","article-title":"Tooth formation and the 28000-dalton vitamin D-dependent calcium-binding protein: an immunocytochemical study","volume":"32","author":"Taylor","year":"1984","journal-title":"J Histochem Cytochem"},{"key":"B54","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1203\/00006450-199604000-00013","article-title":"Immunolocalization of vitamin D receptor and calbindin-D 28k in human tooth germ","volume":"39","author":"Bailleul-Forestier","year":"1996","journal-title":"Pediatr Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s004410051377","article-title":"Immunohistochemical localization of calbindin D28k during root formation of rat molar teeth","volume":"297","author":"Onishi","year":"1999","journal-title":"Cell Tissue Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"762130","DOI":"10.3389\/fendo.2021.762130","article-title":"Calcium transport in the kidney and disease processes","volume":"12","author":"Hanna","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B57","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/B978-0-323-91386-7.00003-9","article-title":"Vitamin D and the kidney","author":"Kritmetapak","year":"2024","journal-title":"Feldman and Pike\u2019s Vitamin D"},{"key":"B58","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/B978-0-12-391934-2.00019-9","article-title":"Calcium, phosphate, PTH, vitamin D and FGF-23 in chronic kidney disease","volume":"1","author":"Voinescu","year":"2013","journal-title":"Nutr Manag Renal Dis"},{"key":"B59","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-1533-6_37","article-title":"Calbindin D28k","volume-title":"Encyclopedia of Metalloproteins","author":"\u00c5kerfeldt","year":"2013"},{"key":"B60","first-page":"12729","article-title":"Vitamin D deficiency and end-stage renal disease (ESRD)","volume":"20","author":"Mohamed","year":"2022","journal-title":"NeuroQuantology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4103\/0972-124X.154178","article-title":"Oral and salivary changes in patients with chronic kidney disease: a clinical and biochemical study","volume":"19","author":"Anuradha","year":"2015","journal-title":"J Indian Soc Periodontol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"759056","DOI":"10.3389\/fphys.2021.759056","article-title":"Assessment of alveolar bone and periodontal Status in peritoneal dialysis patients","volume":"2021","author":"Sun","year":"2021","journal-title":"Front Physiol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3000605211033266","DOI":"10.1177\/03000605211033266","article-title":"Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults","volume":"49","author":"Valenzuela-Narv\u00e1ez","year":"2021","journal-title":"J Int Med Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1902\/jop.2007.060499","article-title":"Does periodontal disease reflect atherosclerosis in continuous ambulatory peritoneal dialysis patients?","volume":"78","author":"Cengiz","year":"2007","journal-title":"J Periodontol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biochi.2014.12.015","article-title":"Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-\u03baB\/iNOS signaling in diabetic rat","volume":"110","author":"Khan","year":"2015","journal-title":"Biochimie"},{"key":"B66","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1900\/RDS.2005.2.19","article-title":"Proteomic identification and immunolocalization of increased renal calbindin-D28k expression in OVE26 diabetic mice","volume":"2","author":"Thongboonkerd","year":"2005","journal-title":"Rev Diabet Stud"},{"key":"B67","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/jcp.20028","article-title":"Effect of calbindin-D28K on cyclosporine toxicity in cultured renal proximal tubular cells","volume":"200","author":"Wu","year":"2004","journal-title":"J Cell Physiol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1210\/endo.142.8.8334","article-title":"Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis","volume":"142","author":"Rabinovitch","year":"2001","journal-title":"Endocrinology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1046\/j.1523-1755.2001.0590041382.x","article-title":"Defective expression of B7-2 (CD86) on monocytes of dialysis patients correlates to the uremia-associated immune defect","volume":"59","author":"Girndt","year":"2001","journal-title":"Kidney Int"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1210\/en.2015-1395","article-title":"Cognitive and disease-modifying effects of 11\u03b2-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease","volume":"156","author":"Sooy","year":"2015","journal-title":"Endocrinology"}],"container-title":["Frontiers in Oral Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2025.1523024\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T05:25:13Z","timestamp":1745558713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2025.1523024\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":70,"alternative-id":["10.3389\/froh.2025.1523024"],"URL":"https:\/\/doi.org\/10.3389\/froh.2025.1523024","relation":{},"ISSN":["2673-4842"],"issn-type":[{"type":"electronic","value":"2673-4842"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"article-number":"1523024"}}