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The purpose of this report is to present a case study of a patient in her 20s who experienced internal root resorption on two maxillary central incisors as a result of orthodontic treatment. Mineral trioxide aggregates (MTAs) were applied to the root resorption lesion to promote remineralization. A clinical and radiographic examination revealed that no radiolucency related to the resorptive lesion was found without any pathological symptoms after a 3-year follow-up.<\/jats:p>","DOI":"10.3389\/froh.2025.1604976","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:34:00Z","timestamp":1755149640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rescuing a \u201chopeless\u201d tooth with severe internal resorption during orthodontic therapy: a case report"],"prefix":"10.3389","volume":"6","author":[{"given":"Wenjing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1043\/0003-3219(1982)05%3C0235:RRIBI%3E2.0.CO;2","article-title":"Root resorption in bicuspid intrusion. 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