{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:40:42Z","timestamp":1784983242627,"version":"3.55.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:p>Most severe presentation of medication-related osteonecrosis of the jaw (MRONJ) is classified as stage 3 for which there are still no standard surgical therapy guideline. Our aim was to describe \u201cFive Times Three (FTT) Split\u201d protocol as surgical treatment of stage 3 maxillary MRONJ. The present case series included a total of 14 patients diagnosed with stage 3 MRONJ of the upper jaw who were treated from February 2022 to September 2024 with mucoperiosteal flap and \u201cFTT Split\u201d protocol. The patients were followed up both clinically and radiologically for a period ranging from 9 months to 3 years. Primary wound closure was successfully achieved in all cases without any signs of oroantral or oronasal communication, and complete healing was observed during the postoperative follow-up period. The \u201cFTT Split\u201d surgical protocol demonstrated high success rates during a controlled postoperative period.<\/jats:p>","DOI":"10.3389\/froh.2025.1694766","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:40:50Z","timestamp":1768977650000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Surgical treatment of stage 3 medication-related osteonecrosis of the maxilla using the \u201cFTT Split\u201d surgical protocol: a report of 14 cases"],"prefix":"10.3389","volume":"6","author":[{"given":"Daniel","family":"Jerkovi\u0107","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split, School of Medicine, University of Split","place":["Split, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante","family":"Mihovilovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split","place":["Split, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante","family":"Pojatina","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split","place":["Split, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Poklepovi\u0107 Peri\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Study of Dental Medicine, University of Split School Medicine","place":["Split, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Stazi\u0107 Kun\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split","place":["Split, Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.coms.2015.06.003","article-title":"The frequency of medication-related osteonecrosis of the jaw and its associated risk factors","volume":"27","author":"Dodson","year":"2015","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e788","DOI":"10.4317\/medoral.22013","article-title":"The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw","volume":"22","author":"Eguchi","year":"2017","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.joms.2022.07.150","article-title":"Reply: AAOMS position paper on medication-related osteonecrosis of the jaws-2022 update. 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