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Drug therapy, including corticosteroids, calcineurin inhibitors, hydroxychloroquine, hyaluronic acid, and mTOR inhibitors, as well as non pharmacological treatments such as autologous platelet concentrates and photodynamic therapy, are the pillars of clinical management. This review is based on 46 articles published between 2020 and 2025, examining current treatment strategies and proposing innovative recommendations to strengthen existing treatments. This study provides new insights into drug combination strategies and non drug alternative treatment options for treating OLP, laying the foundation for future research and clinical trials aimed at developing more effective and personalized treatment plans.<\/jats:p>","DOI":"10.3389\/froh.2026.1713845","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:25:57Z","timestamp":1782192357000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatments in oral lichen planus: a review"],"prefix":"10.3389","volume":"7","author":[{"given":"Ce","family":"Gou","sequence":"first","affiliation":[{"name":"School of Clinical Medical, Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Stomatology, The First Afliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medical, Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Stomatology, The First Afliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medical, Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Stomatology, The First Afliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5280","DOI":"10.3390\/jcm13175280","article-title":"Oral lichen Planus: a narrative review navigating etiologies, clinical manifestations, diagnostics, and therapeutic approaches","volume":"13","author":"Nukaly","year":"2024","journal-title":"J Clin Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1001\/jamadermatol.2019.3797","article-title":"Global prevalence and incidence estimates of oral lichen Planus: a systematic review and meta-analysis","volume":"156","author":"Li","year":"2020","journal-title":"JAMA Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12903-022-02168-4","article-title":"Oral lichen planus: comparative efficacy and treatment costs-a systematic review","volume":"22","author":"Sandhu","year":"2022","journal-title":"BMC Oral Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/jop.12405","article-title":"Role of distinct CD4(+) T helper subset in pathogenesis of oral lichen planus","volume":"45","author":"Wang","year":"2016","journal-title":"Oral Pathol Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.oooo.2016.03.011","article-title":"Etiology and pathogenesis of oral lichen planus: an overview","volume":"122","author":"Kurago","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/odi.12885","article-title":"Rate of malignant transformation of oral lichen planus: a systematic review","volume":"25","author":"Giuliani","year":"2019","journal-title":"Oral Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/19424396.2021.12222696","article-title":"A guide for dental practitioners of common oral potentially malignant disorders","volume":"49","author":"Wang","year":"2021","journal-title":"J Calif Dent Assoc"},{"key":"B8","first-page":"445","article-title":"Malignant transformation of oral lichen planus. 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