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Oral Health"],"abstract":"<jats:p>\n                    Oral squamous cell carcinoma (OSCC) remains a significant health challenge because of its aggressive nature and poor survival outcomes. While established risk factors such as tobacco use, alcohol consumption, and human papillomavirus play critical roles, increasing evidence suggests that oral microbial dysbiosis may contribute to carcinogenesis. Among oral commensals,\n                    <jats:italic>Veillonella<\/jats:italic>\n                    species have gained attention because of their ecological role in oral biofilms and metabolic interactions with other microbes, and have also been increasingly identified in altered abundances within OSCC patient samples. This narrative review synthesizes available clinical, epidemiological, and molecular studies investigating the prevalence and biological roles of\n                    <jats:italic>Veillonella<\/jats:italic>\n                    species in OSCC. Relevant English-language publications between 2000 and 2025 were identified through database searches in Pubmed Scopus and Web of Science using keywords related to\n                    <jats:italic>Veillonella<\/jats:italic>\n                    , oral microbiome, dysbiosis, and OSCC. The reviewed evidence reveals a dynamic and stage-dependent shift in\n                    <jats:italic>Veillonella<\/jats:italic>\n                    abundance during oral carcinogenesis. Several studies report enrichment of\n                    <jats:italic>Veillonella<\/jats:italic>\n                    in oral potentially malignant disorders and early tumorigenesis, whereas reduced levels are frequently observed in advanced OSCC. These findings suggest that\n                    <jats:italic>Veillonella<\/jats:italic>\n                    may function as an ecological modulator of tumor-associated microbiota rather than as a single pathogenic driver. Proposed mechanisms include metabolic cross-feeding with lactic-acid-producing bacteria, modulation of inflammatory pathways, biofilm restructuring, and host\u2013microbe metabolic signaling. Overall, current evidence supports a microbial ecological shift model, in which\n                    <jats:italic>Veillonella<\/jats:italic>\n                    participates in early dysbiotic transitions preceding OSCC development but may decline as tumor microenvironments evolve. Further standardized and multiomics studies are needed to clarify its potential as a microbiome-based biomarker and therapeutic target.\n                  <\/jats:p>","DOI":"10.3389\/froh.2026.1740043","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:52:33Z","timestamp":1778219553000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of Veillonella species in oral carcinogenesis: is prevalence linked to oral squamous cell carcinoma?"],"prefix":"10.3389","volume":"7","author":[{"given":"Citra Fragrantia","family":"Theodorea","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia","place":["Depok, Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadhira Aurynna","family":"Azzahra","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia","place":["Depok, Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Idrus","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia","place":["Depok, Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahrul","family":"Nurkolis","sequence":"additional","affiliation":[{"name":"Institute for Research and Community Service, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga)","place":["Yogyakarta, Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna Adisattya","family":"Djais","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia","place":["Depok, Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Mashima","sequence":"additional","affiliation":[{"name":"Department of Oral Medical Science, 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