{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:41:03Z","timestamp":1773268863714,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oroantral communication (OAC) is an abnormal connection between the oral cavity and maxillary sinus, often occurring after posterior maxillary tooth extraction. If untreated, OAC can progress to oroantral fistulas (OAFs), leading to chronic sinusitis and treatment failure. Platelet-rich fibrin (PRF), an autologous biomaterial with regenerative potential, has been proposed as a therapeutic option. This study aimed to evaluate the efficacy and safety of PRF in the closure of OACs\/OAFs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis followed PRISMA guidelines and was registered with PROSPERO. A comprehensive literature search was conducted in April 2025 across Cochrane, PubMed, Google Scholar and Web of Science. Studies were selected using PICO criteria: patients with OACs\/OAFs; PRF as a standalone or adjunct intervention; comparison to conventional treatments; outcome of successful closure; and human studies published in English or Arabic. Data extraction and risk of bias assessment were performed independently by multiple reviewers using Cochrane RoB 2, MINORS, and MMS tools. Meta-analysis was conducted using Review Manager software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen studies including 442 patients were included. PRF demonstrated high closure rates, often within three weeks, with enhanced mucosal and bone healing. Minimal complications were reported. Although methodological heterogeneity and moderate-to-high risk of bias were observed, the overall findings support the beneficial role of PRF in OAC\/OAF management, particularly in minor to moderate defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRF is a safe, effective, and minimally invasive adjunct for the closure of OACs\/OAFs. Its application is associated with significantly reduced patient morbidity, including less pain, lower analgesic consumption, minimal swelling, and greater overall comfort. Furthermore, as a minimally invasive and entirely autologous material, PRF eliminates the risks of immunogenic reactions or disease transmission, while its application helps preserve critical anatomical structures like the buccal sulcus, which is essential for future prosthetic rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO CRD420251028634.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/froh.2026.1759248","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:53:07Z","timestamp":1773211987000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet-rich fibrin as a therapeutic modality for oroantral communication closure: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"7","author":[{"given":"Manar Kh","family":"Almutiri","sequence":"first","affiliation":[{"name":"Ministry of Health","place":["Kuwait City, Kuwait"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawaf Ahmad","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Farwaniya Hospital","place":["Kuwait City, Kuwait"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurrahman Saud","family":"Almutairy","sequence":"additional","affiliation":[{"name":"Ministry of Health","place":["Madinah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Adnan","family":"Alwosaibai","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University","place":["Buraydah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Alqurayat General Hospital","place":["Alqurayat City, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faris Sultan","family":"Al-Mutairi","sequence":"additional","affiliation":[{"name":"College of Medicine, Taibah University","place":["Madina, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema Hasan","family":"Almutairi","sequence":"additional","affiliation":[{"name":"College of Medicine, Tabuk University","place":["Tabuk, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Khalid","family":"Alsaairi","sequence":"additional","affiliation":[{"name":"Collage of Medicine, King Khalid University","place":["Abha, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Albader","sequence":"additional","affiliation":[{"name":"King Faisal General Hospital, Ministry of Health","place":["Hofuf, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isra","family":"Aljazeeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University","place":["Riyadh, Saudi Arabia"]},{"name":"King Abdullah Ear Specialist Center (KAESC), King Saud University Medical City","place":["Riyadh, Saudi Arabia"]},{"name":"Aljaber Ophthalmology and Otolaryngology Specialized Hospital, Ministry of Health","place":["Ahsa, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.tripleo.2005.08.017","article-title":"Bioabsorbable root analogue for closure of oroantral communications after tooth extraction: a prospective case\u2013cohort study. 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