{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:05:31Z","timestamp":1792019131476,"version":"4.4.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:p>\n                    Oral candidiasis, an opportunistic fungal infection mainly caused by\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , is highly prevalent in immunocompromised individuals. Saliva acts as the oral cavity's first line of defense, with secretory immunoglobulin A (sIgA) as its key specific immune component. In this review, we systematically clarify sIgA's multifaceted roles in oral immunity and its significance in the pathogenesis, progression, and management of oral candidiasis. We detail sIgA's biological characteristics (synthesis, secretion) and core mechanisms: immune exclusion (inhibiting fungal adhesion\/invasion), virulence factor neutralization, biofilm interference, and immune regulation. We also explore sIgA-\n                    <jats:italic>C. albicans<\/jats:italic>\n                    interactions, including antigen recognition, hyphal transition inhibition, and fungal evasion strategies (protease degradation, antigenic variation). Clinical evidence shows that compromised salivary sIgA levels\/function\u2014due to systemic diseases (e.g., HIV\/AIDS, Sj\u00f6gren's syndrome), aging, radiotherapy, or immunosuppression \u2014 correlates with increased susceptibility and severity of oral candidiasis, with functional quality being equally crucial as quantity. Given conventional antifungal limitations, we discuss sIgA-based interventions (recombinant sIgA passive immunization, mucosal vaccines, probiotic adjuvants). In conclusion, salivary sIgA is critical to maintaining oral mucosal homeostasis against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , and enhancing its function offers promising avenues for preventing and treating oral candidiasis.\n                  <\/jats:p>","DOI":"10.3389\/froh.2026.1760095","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:57:58Z","timestamp":1772607478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The roles of salivary secretory IgA on the development of oral candidiasis"],"prefix":"10.3389","volume":"7","author":[{"given":"Jingzhi","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"West China Lecheng Hospital, Sichuan University","place":["Boao, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Lecheng Hospital, Sichuan University","place":["Boao, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunwei","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunting","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Tianfu Jiangxi Laboratory","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.clindermatol.2016.02.022","article-title":"Oral candidiasis","volume":"34","author":"Millsop","year":"2016","journal-title":"Clin Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.archoralbio.2019.05.013","article-title":"Effects of Candida albicans infection on defense effector secretion by human oral mucosal epithelial cells","volume":"103","author":"Huang","year":"2019","journal-title":"Arch Oral Biol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/prd.12378","article-title":"Fungal diseases: oral dysbiosis in susceptible hosts","volume":"87","author":"Villar","year":"2021","journal-title":"Periodontol 2000"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00185","article-title":"Multi-Faceted functions of secretory IgA at mucosal surfaces","volume":"4","author":"Corth\u00e9sy","year":"2013","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.34172\/joddd.2020.041","article-title":"Estimation and correlation of serum and salivary glucose and immunoglobulin A levels and salivary candidal carriage in diabetic and non-diabetic patients","volume":"14","author":"Hegde","year":"2020","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"B6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/imr.13014","article-title":"Know your enemy or find your friend?\u2014induction of IgA at mucosal surfaces","volume":"303","author":"Bemark","year":"2021","journal-title":"Immunol Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3109\/00016358209041120","article-title":"Concentration of immunoglobulins in human whole saliva: effect of physiological stimulation","volume":"40","author":"Gr\u00f6nblad","year":"2009","journal-title":"Acta Odontol Scand"},{"key":"B8","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/s41423-021-00819-0","article-title":"Microbial symphony orchestrated by mucosal IgA","volume":"19","author":"Reyes-Ruiz","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00553","article-title":"Iga and Fc\u03b1RI: pathological roles and therapeutic opportunities","volume":"10","author":"Breedveld","year":"2019","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/mi.2011.39","article-title":"Structure and function relationships in IgA","volume":"4","author":"Woof","year":"2011","journal-title":"Mucosal Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092307","article-title":"Oral microbiota: the influences and interactions of Saliva, IgA, and dietary factors in health and disease","volume":"11","author":"Nagakubo","year":"2023","journal-title":"Microorganisms"},{"key":"B12","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/mi.2011.36","article-title":"The human immunoglobulin A fc receptor Fc\u03b1RI: a multifaceted regulator of mucosal immunity","volume":"4","author":"Bakema","year":"2011","journal-title":"Mucosal Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147520","article-title":"Molecular mapping of antifungal mechanisms accessing biomaterials and new agents to target oral candidiasis","volume":"23","author":"Anu\u021ba","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"102627","DOI":"10.1016\/j.pdpdt.2021.102627","article-title":"Photodynamic therapy to control oral candidiasis in a pediatric patient undergoing head and neck radiotherapy","volume":"37","author":"Rojz","year":"2022","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B16","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00520-021-06480-7","article-title":"Effects of a miconazole oral patch on preventing development of oral candidiasis in patients with head and neck cancer undergoing radiotherapy: results of a preliminary study quantifying the prevalence of Candida albicans in saliva","volume":"30","author":"Funahara","year":"2021","journal-title":"Support Care Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1111\/apm.13412","article-title":"Pathophysiological microenvironments in oral candidiasis","volume":"132","author":"J\u00f8rgensen","year":"2024","journal-title":"Apmis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/jof7020079","article-title":"Candida albicans\u2014the virulence factors and clinical manifestations of infection","volume":"7","author":"Talapko","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/odi.12380","article-title":"Efficacy and safety of miconazole for oral candidiasis: a systematic review and meta-analysis","volume":"22","author":"Zhang","year":"2015","journal-title":"Oral Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.31083\/j.fbe1501006","article-title":"Use of probiotics for oral candidiasis: state of the art and perspective. A further step toward personalized medicine?","volume":"15","author":"Contaldo","year":"2023","journal-title":"Front Biosci (Elite Ed)"},{"key":"B21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.prosdent.2019.12.025","article-title":"Efficacy of antifungal drugs in the treatment of oral candidiasis: a Bayesian network meta-analysis","volume":"125","author":"Fang","year":"2021","journal-title":"J Prosthet Dent"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01721-x","article-title":"An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study","volume":"21","author":"Chitapanarux","year":"2021","journal-title":"BMC Oral Health"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010012","article-title":"Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation","volume":"18","author":"Krysan","year":"2022","journal-title":"PLoS Pathog"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.555363","article-title":"Mucosal IgA prevents commensal Candida albicans dysbiosis in the oral cavity","volume":"11","author":"Millet","year":"2020","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"918","DOI":"10.13343\/j.cnki.wsxb.20220528","article-title":"Candida-epithelial interactions","volume":"63","author":"Wang","year":"2023","journal-title":"Acta Microbiol Sin"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/s41385-021-00413-7","article-title":"Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis","volume":"14","author":"Lin","year":"2021","journal-title":"Mucosal Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.1016\/j.vaccine.2006.12.001","article-title":"Induction of secretory immunity and memory at mucosal surfaces","volume":"25","author":"Brandtzaeg","year":"2007","journal-title":"Vaccine"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-12-36","article-title":"Effects of salivary protein flow and indigenous microorganisms on initial colonization of Candida albicans in an in vivo model","volume":"12","author":"Kanaguchi","year":"2012","journal-title":"BMC Oral Health"},{"key":"B29","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1529-8019.2010.01320.x","article-title":"Oral candidiasis and angular cheilitis","volume":"23","author":"Sharon","year":"2010","journal-title":"Dermatol Ther"},{"key":"B30","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1128\/jcm.33.2.432-439.1995","article-title":"Reduced inhibition of Candida albicans adhesion by saliva from patients receiving oral cancer therapy","volume":"33","author":"Umazume","year":"1995","journal-title":"J Clin Microbiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1034\/j.1399-302x.2001.016005270.x","article-title":"Salivary anticandidal activity and saliva composition in an HIV-infected cohort","volume":"16","author":"Lin","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.archoralbio.2009.04.003","article-title":"The role of salivary factors in persistent oral carriage of Candida in humans","volume":"54","author":"Hibino","year":"2009","journal-title":"Arch Oral Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/path.1877","article-title":"The function of immunoglobulin A in immunity","volume":"208","author":"Woof","year":"2005","journal-title":"J Pathol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00281-021-00879-4","article-title":"The immune landscape of IgA induction in the gut","volume":"43","author":"Seikrit","year":"2021","journal-title":"Semin Immunopathol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1365-2249.2004.02394.x","article-title":"Serum and salivary IgA antibody responses to Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans in orofacial granulomatosis and crohn\u2019s disease","volume":"135","author":"Savage","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.autrev.2012.10.012","article-title":"Role of secretory IgA in infection and maintenance of homeostasis","volume":"12","author":"Corth\u00e9sy","year":"2013","journal-title":"Autoimmun Rev"},{"key":"B37","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/mi.2011.37","article-title":"Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity","volume":"4","author":"Johansen","year":"2011","journal-title":"Mucosal Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"688","DOI":"10.4161\/19490976.2014.983763","article-title":"Role of secretory IgA in the mucosal sensing of commensal bacteria","volume":"5","author":"Mathias","year":"2014","journal-title":"Gut Microbes"},{"key":"B39","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.molimm.2007.07.001","article-title":"Rat salivary gland reveals a more restricted IgA repertoire than ileum","volume":"45","author":"Stoel","year":"2008","journal-title":"Mol Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1034\/j.1600-0714.2003.00015.x","article-title":"Decreased excretion of antimicrobial proteins and peptides in saliva of patients with oral candidiasis","volume":"32","author":"Tanida","year":"2003","journal-title":"J Oral Pathol Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1002\/bit.26403","article-title":"Comparative analysis of plant-produced, recombinant dimeric IgA against cell wall \u03b2-glucan of pathogenic fungi","volume":"114","author":"Capodicasa","year":"2017","journal-title":"Biotechnol Bioeng"},{"key":"B42","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.jaci.2023.03.033","article-title":"Intestinal Candida albicans overgrowth in IgA deficiency","volume":"152","author":"Moreno-Sabater","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00222","article-title":"Secretory IgA: designed for anti-microbial defense","volume":"4","author":"Brandtzaeg","year":"2013","journal-title":"Front Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.4049\/jimmunol.1300864","article-title":"Secretory IgA induces tolerogenic dendritic cells through SIGNR1 dampening autoimmunity in mice","volume":"191","author":"Diana","year":"2013","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1002\/eji.200323534","article-title":"Human NK cells express fc receptors for IgA which mediate signal transduction and target cell killing","volume":"33","author":"Mota","year":"2003","journal-title":"Eur J Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/154411130301400403","article-title":"Chronic hyperplastic candidosis\/candidiasis (candidal leukoplakia)","volume":"14","author":"Sitheeque","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1997.tb00381.x","article-title":"Salivary and mucosal immune responses to HIV and its co-pathogens","volume":"3","author":"Challacombe","year":"2013","journal-title":"Oral Dis"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s00520-019-04885-z","article-title":"Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: a retrospective multicenter study of 326 patients","volume":"28","author":"Nishii","year":"2019","journal-title":"Support Care Cancer"},{"key":"B49","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.oraloncology.2003.12.013","article-title":"Cytotoxic drugs, radiotherapy and oral candidiasis","volume":"40","author":"Soysa","year":"2004","journal-title":"Oral Oncol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/8701423","article-title":"Salivary secretory immunoglobulin (SIgA) and lysozyme in malignant tumor patients","volume":"2016","author":"Sun","year":"2016","journal-title":"BioMed Res Int"},{"key":"B51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10875-009-9357-x","article-title":"Selective IgA deficiency","volume":"30","author":"Yel","year":"2010","journal-title":"J Clin Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02969-1","article-title":"Oral candidiasis and cigarette, tobacco, alcohol, and opium consumption in Rafsanjan, a region in the southeast of Iran","volume":"23","author":"Khalili","year":"2023","journal-title":"BMC Oral Health"},{"key":"B53","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41586-021-03722-w","article-title":"Adaptive immunity induces mutualism between commensal eukaryotes","volume":"596","author":"Ost","year":"2021","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jdent.2009.09.005","article-title":"Levels of salivary IgA antibodies to Candida spp. In HIV-infected adult patients: a systematic review","volume":"38","author":"Pomarico","year":"2010","journal-title":"J Dent"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0868-4","article-title":"Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes","volume":"19","author":"Kheirmand Parizi","year":"2019","journal-title":"BMC Oral Health"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e507","DOI":"10.18295\/2075-0528.1736","article-title":"Evaluation of salivary secretory immunoglobulin A levels in diabetic patients and association with oral and dental manifestations","volume":"15","author":"Kakoei","year":"2015","journal-title":"Sultan Qaboos Univ Med J"},{"key":"B57","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1034\/j.1399-302x.2000.150503.x","article-title":"Serum and salivary antibodies to a mycobacterial 65-kDa stress protein are elevated in HIV-positive patients and modified by oral candidiasis","volume":"15","author":"Coogan","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3109\/00016359009012733","article-title":"Oral adhesion of yeasts","volume":"48","author":"Olsen","year":"2009","journal-title":"Acta Odontol Scand"},{"key":"B59","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.riam.2011.07.004","article-title":"Phosphoglycerate kinase and fructose bisphosphate aldolase of Candida albicans as new antigens recognized by human salivary IgA","volume":"29","author":"Calcedo","year":"2012","journal-title":"Rev Iberoam Micol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-024-13063-z","article-title":"Secretory IgA reduced the ergosterol contents of Candida albicans to repress its hyphal growth and virulence","volume":"108","author":"Wang","year":"2024","journal-title":"Appl Microbiol Biotechnol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","article-title":"Candida albicans secreted aspartyl proteinases in virulence and pathogenesis","volume":"67","author":"Naglik","year":"2003","journal-title":"Microbiol Mol Biol Rev"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1177\/00220345960750121001","article-title":"Reactivity of Candida albicans germ tubes with salivary secretory IgA","volume":"75","author":"Ponton","year":"1996","journal-title":"J Dent Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1177\/00220345000790061401","article-title":"Influence of environmental pH on the reactivity of Candida albicans with salivary IgA","volume":"79","author":"Bikandi","year":"2000","journal-title":"J Dent Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.2174\/0929867325666180601102333","article-title":"Promising alternative therapeutics for oral candidiasis","volume":"26","author":"Rodrigues","year":"2019","journal-title":"Curr Med Chem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mehy.2017.06.029","article-title":"The potential management of oral candidiasis using anti-biofilm therapies","volume":"106","author":"Chanda","year":"2017","journal-title":"Med Hypotheses"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-06468-3","article-title":"Efficacy of probiotics for oral candidiasis management: a systematic review","volume":"25","author":"Li","year":"2025","journal-title":"BMC Oral Health"},{"key":"B67","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1590\/S0103-64402012000500011","article-title":"Effects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderly","volume":"23","author":"Mendon\u00e7a","year":"2012","journal-title":"Braz Dent J"},{"key":"B68","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1590\/S1517-83822009000400030","article-title":"Influence of probiotics on Candida presence and IgA anti-Candida in the oral cavity","volume":"40","author":"Santos","year":"2009","journal-title":"Braz J Microbiol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00018-015-2074-0","article-title":"Recombinant IgA production for mucosal passive immunization, advancing beyond the hurdles","volume":"73","author":"Virdi","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1111\/pbi.14576","article-title":"Enhancing quality and yield of recombinant secretory IgA antibodies in Nicotiana benthamiana by endoplasmic reticulum engineering","volume":"23","author":"G\u00f6ritzer","year":"2025","journal-title":"Plant Biotechnol J"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007460","article-title":"The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection","volume":"15","author":"Gaffen","year":"2019","journal-title":"PLoS Pathog"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061908","article-title":"Efficacy of a multi-strain probiotic formulation in pediatric populations: a comprehensive review of clinical studies","volume":"13","author":"Tremblay","year":"2021","journal-title":"Nutrients"},{"key":"B73","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1439-0507.2008.01594.x","article-title":"Relationship between serum and saliva antibodies to Candida and isolation of Candida species from the mucosa of HIV-infected individuals","volume":"52","author":"Castro","year":"2009","journal-title":"Mycoses"},{"key":"B74","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1034\/j.1600-0528.2000.028005373.x","article-title":"Salivary alterations in type 2 (non-insulin-dependent) diabetes mellitus and hypertension","volume":"28","author":"Dodds","year":"2002","journal-title":"Community Dent Oral Epidemiol"}],"container-title":["Frontiers in Oral Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2026.1760095\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:58:00Z","timestamp":1772607480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2026.1760095\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":74,"alternative-id":["10.3389\/froh.2026.1760095"],"URL":"https:\/\/doi.org\/10.3389\/froh.2026.1760095","relation":{},"ISSN":["2673-4842"],"issn-type":[{"value":"2673-4842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]},"article-number":"1760095"}}