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This mini-review (2015\u20132025) summarizes nanomaterial-based approaches for managing implant-associated oral biofilms, including passive surface functionalization, active delivery systems, externally triggered therapies, and host-directed osteoimmunomodulation. Their potential should be interpreted in light of evidence maturity, safety\u2014especially for ROS-based modalities\u2014and long-term tribological and manufacturing limitations. We also highlight practical selection by disease stage and host risk, while emphasizing key translational gaps, particularly validation in mixed-species biofilms and long-term biocompatibility.<\/jats:p>","DOI":"10.3389\/froh.2026.1789632","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:32:38Z","timestamp":1775626358000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Nanomaterial-based strategies for oral biofilm management: functionalized implants and targeted delivery systems"],"prefix":"10.3389","volume":"7","author":[{"given":"Liu","family":"Yuming","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Universiti Kebangsaan Malaysia","place":["Kuala Lumpur, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhenkun","sequence":"additional","affiliation":[{"name":"Center for Health Ageing and Wellness, Faculty of Health 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