{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:53:02Z","timestamp":1777679582657,"version":"3.51.4"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:p>Bisphosphonates (BPs) are widely used for managing tumor metastasis and bone diseases, associated with a rare complication of medication-related osteonecrosis of the jaws (MRONJ). Though reasons are still debated, the MRONJ occurrence in paediatric population suffering osteogenesis imperfecta (OI) and treated with BPs is absent. Here, we reported a 33-year-old patient with OI (Type III) who developed MRONJ after receiving intravenous pamidronate from 16 years old. She complained of intermittent nasal bleeding for six years, and presented an exposed necrotic bone in the left maxilla. She underwent surgical debridement, and pathological examination confirmed MRONJ. To our knowledge, this was a very rare case of MRONJ in an adult with OI type III following pediatric BP exposure. This case underscored the need for long-term vigilance, as delayed onset into adulthood is possible. Clinicians should pay attention to sinonasal symptoms as potential manifestations of MRONJ, and strengthen dental preventive care to reduce local risk factors. Long-term follow-up longitudinal studies with a larger sample size in this population are needed.<\/jats:p>","DOI":"10.3389\/froh.2026.1790684","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:47:51Z","timestamp":1773038871000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Medication-related osteonecrosis of the jaw in an adult with osteogenesis imperfecta: a case report"],"prefix":"10.3389","volume":"7","author":[{"given":"Wang-yong","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dental Surgery, The University of Hong Kong-Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, The University of Hong Kong-Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]},{"name":"School of Stomatology , Jinan University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-An","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, Head and Neck Surgery, The University of Hong Kong-Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, The University of Hong Kong-Shenzhen Hospital","place":["Shenzhen, Guangdong, China"]},{"name":"School of Stomatology , Jinan University","place":["Guangzhou, China"]},{"name":"Shenzhen Clinical Research Center for Rare Diseases","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of oral and maxillofacial Surgeons\u2019 position paper on medication-related osteonecrosis of the jaws-2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J Oral Maxillofac Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J Bone Miner Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jocd.2016.09.005","article-title":"Case-Based review of osteonecrosis of the jaw (ONJ) and application of the international recommendations for management from the international task force on ONJ","volume":"20","author":"Khan","year":"2017","journal-title":"J Clin Densitom"},{"key":"B4","doi-asserted-by":"publisher","first-page":"R95","DOI":"10.1530\/EJE-20-0299","article-title":"Osteogenesis imperfecta: an update on clinical features and therapies","volume":"183","author":"Marom","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.5037\/jomr.2013.4401","article-title":"Systematic review on the incidence of bisphosphonate related osteonecrosis of the jaw in children diagnosed with osteogenesis imperfecta","volume":"4","author":"Hennedige","year":"2013","journal-title":"J Oral Maxillofac Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.joms.2022.06.026","article-title":"Medication-related osteonecrosis of the jaws in the pediatric population","volume":"80","author":"Neal","year":"2022","journal-title":"J Oral Maxillofac 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research for multimodality medical management","volume":"32","author":"Abdolrahmani","year":"2024","journal-title":"Support Care Cancer"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.5037\/jomr.2023.14401","article-title":"Comparison of the effectiveness of conservative and surgical treatment of medication-related osteonecrosis of the jaw: a systematic review","volume":"14","author":"Seluki","year":"2023","journal-title":"J Oral Maxillofac Res"}],"container-title":["Frontiers in Oral Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2026.1790684\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:47:52Z","timestamp":1773038872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2026.1790684\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":14,"alternative-id":["10.3389\/froh.2026.1790684"],"URL":"https:\/\/doi.org\/10.3389\/froh.2026.1790684","relation":{},"ISSN":["2673-4842"],"issn-type":[{"value":"2673-4842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"article-number":"1790684"}}