{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:31:59Z","timestamp":1786422719522,"version":"build-2736575974"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lip, oral cavity and pharyngeal cancer (LOCP) comprises a clinically relevant spectrum of contiguous head-and-neck malignancies, yet large real-world datasets with linked blood data remain uncommon. This study investigated demographic, comorbidity-related, gingival\/periodontal, and routine laboratory correlates of recorded ICD-10 C00-C14 LOCP cancer status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This patient-level cross-sectional study included 333,807 unique patients from 805,989 clinical records at the University of Debrecen between 2007 and 2022. Descriptive analyses used Pearson's chi-squared and Wilcoxon rank-sum tests. Multivariable logistic regression was applied in four primary models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 1,963 patients (0.59%) had recorded LOCP cancer status. In the base clinical model, LOCP cancer status was associated with male sex (OR=3.95, 95% CI: 3.56\u20134.38), age 45\u201364 years (OR=10.67, 95% CI: 8.86\u201312.86), age \u226565 years (OR=7.27, 95% CI: 5.97\u20138.85), and K05-coded gingival\/periodontal disease (OR=8.23, 95% CI: 6.16\u201310.98). Among biomarkers, log-transformed CRP showed the clearest independent association (OR per 1-SD increase\u2009=\u20091.55, 95% CI: 1.47\u20131.65), while hemoglobin was inversely associated (OR per 1-SD increase\u2009=\u20090.74, 95% CI: 0.71\u20130.79). CRP quartiles showed a graded pattern, with Q4 associated with higher odds than Q1 (OR=3.73, 95% CI: 3.01\u20134.63). Biomarkers modestly improved AUC in complete-case subsets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recorded LOCP cancer status was associated with a distinct inflammatory and hematological profile, mainly higher CRP and lower hemoglobin. Longitudinal, site-specific datasets with richer behavioral and tumor-level information are needed before these markers can be interpreted as predictive or etiological indicators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/froh.2026.1888417","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:20:42Z","timestamp":1786422042000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and laboratory biomarker correlates of lip, oral cavity, and pharyngeal cancer status in a large retrospective clinical database"],"prefix":"10.3389","volume":"7","author":[{"given":"Amr Sayed","family":"Ghanem","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"Bata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e1ta J\u00e1vorn\u00e9","family":"Erdei","sequence":"additional","affiliation":[{"name":"Department of Health Methodology and Prevention, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen","place":["Ny\u00edregyh\u00e1za, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"M\u00f3r\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Social and Sociological Sciences, Faculty of Health Sciences, University of Debrecen","place":["Ny\u00edregyh\u00e1za, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila Csaba","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","year":""},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3322\/caac.70048","article-title":"Global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2022","volume":"76","author":"Rumgay","year":"2026","journal-title":"CA Cancer J Clin"},{"key":"B3","volume-title":"Global Cancer Observatory: Cancer Today. 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