{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:04:16Z","timestamp":1789362256896,"version":"build-2803163510"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:p>\n                    Poor oral health is commonly linked to cardiovascular disease through the established association between periodontitis and systemic inflammation. This relationship is usually explained by bacterial dissemination from periodontal pockets, lipid dysregulation, and oxidative stress, all of which may contribute to endothelial dysfunction and atherothrombotic changes. However, this conventional framework leaves an important question unresolved: if the main infectious and inflammatory niches are removed after complete tooth loss (edentulism), how does edentulism remain associated with increased cardiovascular risk? Epidemiological studies consistently show that edentulous individuals continue to have elevated cardiovascular morbidity and mortality, yet mechanistic explanations for this association remain underdeveloped. Therefore, this paper proposes a plausible biological model to explain persistent cardiovascular risk in edentulism. The model argues that, after tooth loss, the oral environment is not biologically inert but rather reorganised into a distinct ecological and immunological niche shaped by dentures, altered salivary flow, nutrient changes, microtrauma, and residual soft-tissue biofilms. The tongue, oral mucosa, saliva, and denture surfaces may support persistent colonisation by\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and other organisms within distinct soft-tissue and prosthesis-associated biofilms. The model further proposes that local ecological stress, altered nutrient availability, and cytokine changes may favour regulatory T-cell-associated immune tolerance and impair antimicrobial clearance. Microbial products and outer membrane vesicles may provide additional routes of host signalling, although persister-specific OMV production and its vascular relevance in edentulism remain unconfirmed. Persistent cardiovascular risk after tooth loss is likely multifactorial, and the proposed microbial\u2013immune mechanism represents a complementary framework for future longitudinal, microbiological, immunological, and interventional research.\n                  <\/jats:p>","DOI":"10.3389\/froh.2026.1895121","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:32:38Z","timestamp":1789360358000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tregs and persistent P. gingivalis colonisation: a plausible mechanism for cardiovascular risk in edentulism"],"prefix":"10.3389","volume":"7","author":[{"given":"Jelena","family":"Roganovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Dental Medicine, Department of Pharmacology in Dentistry, University of Belgrade","place":["Belgrade, 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