{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:20:18Z","timestamp":1787818818298,"version":"build-2784847793"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oral Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Type II Diabetes Mellitus (T2DM) and periodontitis present an independent bidirectional relationship. While T2DM is associated with a higher prevalence, incidence, and severity of periodontitis, periodontitis might worsen glycemic control and inflammatory biomarker levels in diabetics. Although there is no standardized therapy for the treatment of diabetic patients with periodontitis, different periodontal interventions report improvements in clinical and cardiometabolic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To summarize the current evidence regarding the clinical management of patients with T2DM and periodontitis, with a secondary focus on the impact of periodontal interventions on cardiometabolic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A literature search was conducted between 2010 and 2026. Information about the clinical management of periodontitis in individuals with T2DM and its impact on cardiometabolic biomarkers was classified and summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A comprehensive periodontal examination and diagnosis should be performed, with close collaboration with the patient's physician. Prior dental treatment, capillary blood glucose between 70 and 180\u2005mg\/dL, and up to 240\u2005mg\/dL in emergency procedures are suggested. The EFP's stepwise treatment approach is recommended, considering periodontal therapy in multiple sessions. Antibiotic therapy or prophylaxis are not recommended in all cases, whereas periodontal maintenance may be required every 3\u20136 months. Periodontal interventions in diabetic individuals have been shown to decrease glycated hemoglobin (HbA1c) and C-reactive protein (CRP), together with other inflammatory and cardiometabolic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with T2DM benefit from several periodontal treatment strategies, with a positive impact on inflammatory and cardiometabolic biomarkers associated with eventual reductions in diabetic control and systemic inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/froh.2026.1922284","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:03:31Z","timestamp":1787817811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal management in patients with diabetes: the impact of periodontal treatment on cardiometabolic biomarkers"],"prefix":"10.3389","volume":"7","author":[{"given":"Alicia","family":"Morales","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]},{"name":"Centro de Epidemiologia y Vigilancia de las Enfermedades Orales (CEVEO), Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]},{"name":"Interuniversity Center for Healthy Aging (CIES), Consortium of State Universities (CUECH)","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"S\u00e1enz-Ravello","sequence":"additional","affiliation":[{"name":"Centro de Epidemiologia y Vigilancia de las Enfermedades Orales (CEVEO), Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Matamala","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Baeza","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]},{"name":"Centro de Epidemiologia y Vigilancia de las Enfermedades Orales (CEVEO), Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hern\u00e1ndez-R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","year":"2024"},{"key":"B2","year":"2025"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J Clin Periodontol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jre.70133","article-title":"Periodontal diseases as a public health challenge: rationale, prevention, equity, and sustainable care\u2014a global call for action","author":"Peres","year":"2026","journal-title":"J Periodontal Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"103883","DOI":"10.1016\/j.identj.2025.103883","article-title":"Global and regional burden of periodontal disease in adults (1990\u20132021)","volume":"75","author":"Wang","year":"2025","journal-title":"Int Dent J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1177\/00220345251388340","article-title":"Understanding the periodontitis\u2013diabetes linkage: mechanisms and evidence","volume":"105","author":"Graves","year":"2026","journal-title":"J Dent Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e555","DOI":"10.1016\/S2468-2667(26)00045-9","article-title":"Oral health and diabetes: a systematic review and meta-analysis","volume":"11","author":"Botelho","year":"2026","journal-title":"Lancet Public Health"},{"key":"B8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s00592-018-1120-4","article-title":"Does diabetes increase the risk of periodontitis? 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