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Considerable comorbidity exists between the two conditions and needs to be taken into account when treating fibroids and\/or endometriosis. The genetic foundations of both uterine fibroids and endometriosis remain to be fully understood but recent evidence suggest common underpinnings. Here, we discuss the comorbidity of uterine fibroids and endometriosis and the implications for diagnosis, treatment and risks.<\/jats:p>","DOI":"10.3389\/frph.2021.750018","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T02:15:02Z","timestamp":1635214502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Endometriosis and Uterine Fibroids (Leiomyomata): Comorbidity, Risks and Implications"],"prefix":"10.3389","volume":"3","author":[{"given":"Outi","family":"Uimari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Nazri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tapmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15112","DOI":"10.1038\/ncomms15112","article-title":"An extra-uterine system to physiologically support the extreme premature lamb","volume":"8","author":"Partridge","year":"2017","journal-title":"Nat Commun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1001356","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PLoS Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1093\/humrep\/dem046","article-title":"International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care","volume":"22","author":"Boivin","year":"2007","journal-title":"Hum Reprod."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat Rev Dis Prim."},{"key":"B6","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.bpobgyn.2008.01.008","article-title":"Clinical presentation of fibroids","volume":"22","author":"Gupta","year":"2008","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1056\/NEJMra1209993","article-title":"Uterine fibroids","volume":"369","author":"Longo","year":"2013","journal-title":"N Engl J Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG An Int J Obstet Gynaecol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/humupd\/dmu021","article-title":"Peripheral changes in endometriosis-associated pain","volume":"20","author":"Morotti","year":"2014","journal-title":"Hum Reprod Update."},{"key":"B10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejogrb.2016.07.497","article-title":"Mechanisms of pain in endometriosis","volume":"209","author":"Morotti","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.fertnstert.2014.02.012","article-title":"Treatment of pelvic pain associated with endometriosis: a committee opinion","volume":"927","year":"2014","journal-title":"Fertil Steril"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.socscimed.2009.07.023","article-title":"The etiquette of endometriosis: stigmatisation. 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