{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:16:01Z","timestamp":1790136961326,"version":"4.0.1"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>One of the most critical functions of the fetal membranes is to remain intact until the onset of labor to maintain the protective intrauterine fluid environment. In most pregnancies, spontaneous rupture usually occurs near the end of the first stage of labor. Preterm premature membrane rupture (PROM) occurs when the fetal membrane ruptures before 37 weeks of pregnancy, and it contributes to adverse maternal, fetal, and neonatal outcomes. Therefore, this study aimed to determine the association of determinant factors with adverse perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted on pregnant women with preterm premature membrane rupture (<jats:italic>n<\/jats:italic>\u2009=\u2009160) attending the teaching hospitals at Addis Ababa University. Socio-demographic and obstetric risk factors with adverse perinatal outcomes include the 5th minute Apgar score, neonatal intensive care unit (NICU) admission, early-onset neonatal sepsis (EONS), respiratory distress syndrome (RDS), perinatal mortality, Chorioamnionitis, and placental abruption were assessed. SPSS version 24,<jats:italic>t<\/jats:italic>-test,<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>test, and logistic regression analysis were used.<jats:italic>P<\/jats:italic>-values &amp;lt;0.25 in the bivariate and<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05 in the multiple logistic regression were considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The preterm (PROM) rate was 2.2% with perinatal mortality rate of 206\/1,000. Gestational age (GA) at delivery was the determinate for low Apgar score at the 5th minute (AOR: 7.23; 95% CI, 1.10, 47.6;<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Unable to use steroid (AOR: 8.23; 95% CI, 1.83, 37.0;<jats:italic>p<\/jats:italic>\u2009=\u20090.000), GA at membrane rupture (AOR: 4.61; 95% CI, 1.98, 31.8;<jats:italic>p<\/jats:italic>\u2009=\u20090.000) and delivery (AOR: 4.32; 95% CI, 1.99, 30.9;<jats:italic>p<\/jats:italic>\u2009=\u20090.000) were determinates for NICU admission. EONS was significantly affected by GA at membrane rupture (AOR: 5.9; 95% CI, 1.01, 37.0;<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Placental abruption was significantly affected by GA at delivery (AOR: 7.52; 95% CI, 1.15, 48.96;<jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GA at membrane rupture and delivery was the most critical predictors of adverse perinatal outcomes. Local guidelines on the approach and preterm PROM outcome management need to be prepared.<\/jats:p><\/jats:sec>","DOI":"10.3389\/frph.2022.1052827","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T06:31:30Z","timestamp":1671085890000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants for perinatal adverse outcomes among pregnant women with preterm premature rupture of membrane: A prospective cohort study"],"prefix":"10.3389","volume":"4","author":[{"given":"Tariku Abewa","family":"Abebe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawit Desalegn","family":"Nima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitbarek Fantahun","family":"Mariye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abebaye Aragaw","family":"Leminie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"B1","first-page":"285","article-title":"Analysis of maternal and perinatal outcome in cases of preterm premature rupture of membranes","volume":"57","author":"Mohokar","year":"2015","journal-title":"Bombay Hosp J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/s0029-7844(02)02366-9","article-title":"Preterm premature rupture of the membranes","volume":"101","author":"Mercer","year":"2003","journal-title":"Obstet Gynecol"},{"key":"B3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/9781119001256.ch43","article-title":"Premature rupture of the membranes","volume-title":"Protocols for high-risk pregnancies an evidence-based approach","author":"Mercer","year":"2015"},{"key":"B4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4236\/ojog.2021.113023","article-title":"Prevalence, risk factors and outcome of preterm premature rupture of membranes at the bamenda regional hospital","volume":"11","author":"Pisoh","year":"2021","journal-title":"Open J Obstet Gynecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0301-2115(99)00257-2","article-title":"Clinical significance and outcome of preterm prelabor rupture of membranes: population-based study","volume":"92","author":"Furman","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B6","first-page":"1091","article-title":"Prelabor rupture of the membranes","volume-title":"High-risk pregnancy: Management options","author":"John","year":"2011"},{"key":"B7","first-page":"11","article-title":"Contemporary diagnosis and management of preterm premature rupture of membranes","volume":"1","author":"Caughey","year":"2008"},{"key":"B8","first-page":"1","article-title":"Maternal and perinatal outcome of pregnancies with preterm premature rupture of membranes (PPROM) at tikur anbessa specialized teaching hospital, Addis Ababa, Ethiopia","volume":"52","author":"Sirak","year":"2014","journal-title":"Ethiop Med J"},{"key":"B9","first-page":"163","article-title":"Incidence, maternal and perinatal outcome of premature rupture of fetal membrane cases in jimma university teaching hospital","volume":"4","author":"Segni","year":"2017","journal-title":"South West Ethiopia. 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