{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:26:15Z","timestamp":1789928775905,"version":"4.0.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Risk of heterotopic pregnancy following bilateral salpingectomy has increased considerably due to the widespread use of assisted reproductive technology. Poor understanding of this condition often causes delayed or missed diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this report, we describe the case of a 30-year-old pregnant woman with lower abdominal pain lasting for half a day and a history of bilateral salpingectomy. Two embryos had been transferred 21 days preceding her presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Laparoscopic surgery revealed intraperitoneal hemorrhage and proper ovarian ligament pregnancy confirmed by histopathology. Viable intrauterine pregnancy was verified 3 days later by ultrasound examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Heterotopic pregnancy is a serious condition that may be life-threatening. Clinicians should be aware of the potential for heterotopic pregnancy in patients receiving <jats:italic>in vitro<\/jats:italic> fertilization and embryo transfer after bilateral salpingectomy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/frph.2022.921141","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T04:56:11Z","timestamp":1658120171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Abdominal heterotopic pregnancy after in vitro fertilization and embryo transfer following bilateral salpingectomy: A case report and literature review"],"prefix":"10.3389","volume":"4","author":[{"given":"Yifeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangdi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e235893","DOI":"10.1136\/bcr-2020-235893","article-title":"Caution with bilateral salpingectomy and consideration of tubal stump ectopic in IVF","volume":"13","author":"Yip","year":"2020","journal-title":"BMJ Case Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejogrb.2020.08.046","article-title":"Ectopic pregnancy following in vitro fertilization after bilateral salpingectomy: a review of the literature","volume":"254","author":"OuYang","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1056\/NEJMicm1509537","article-title":"Heterotopic pregnancy","volume":"375","author":"Goettler","year":"2016","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/01.JAA.0000654012.56086.97","article-title":"Heterotopic pregnancy: simultaneous viable and nonviable pregnancies","volume":"33","author":"Hewlett","year":"2020","journal-title":"JAAPA."},{"key":"B5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ejogrb.2014.04.046","article-title":"Management and outcome of 25 heterotopic pregnancies in Zhejiang, China","volume":"180","author":"Yu","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.jmig.2015.11.013","article-title":"Heterotopic pregnancy after in vitro fertilization and embryo transfer after bilateral total salpingectomy\/tubal ligation: case report and literature review","volume":"23","author":"Xu","year":"2016","journal-title":"J Minim Invasive Gynecol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.rbmo.2012.10.006","article-title":"Unusual case of recurrent heterotopic pregnancy after bilateral salpingectomy and literature review","volume":"26","author":"Shavit","year":"2013","journal-title":"Reprod Biomed Online."},{"key":"B8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/01443615.2012.727045","article-title":"Ruptured heterotopic pregnancy after assisted reproduction in a patient who underwent bilateral salpingectomy","volume":"33","author":"Zhaoxia","year":"2013","journal-title":"J Obstet Gynaecol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40001-018-0316-y","article-title":"Clinical analysis of 50 patients with heterotopic pregnancy after ovulation induction or embryo transfer","volume":"23","author":"Wu","year":"2018","journal-title":"Eur J Med Res."},{"key":"B10","first-page":"747","article-title":"Concomitant abdominal and intrauterine pregnancy after in vitro fertilization in a woman with bilateral salpingectomy. 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