{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:23:13Z","timestamp":1788801793173,"version":"build-2803163510"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:p>Erectile dysfunction (ED) is one of the commonest disorders in adult males and affects 12\u201319% of men of reproductive age. Only few studies have evaluated the impact of ED on men and couples with infertility\u2014these studies report higher rates of ED in this sub-group of men compared to the general population, with the prevalence of ED in men diagnosed with male infertility ranging from 6.7 to 61.6%. Nevertheless, ED is considered a rare cause of male infertility, accounting for about 0.4\u20135% of all causes of male infertility. ED remains a poorly treated condition globally and current therapies, like oral medication, offer only temporary symptomatic relief and do not influence disease progression\u2014patients are potentially on lifelong treatment, with ED worsening over time. In contrast, regenerative medicine may potentially reverse or halt the progression of ED processes. In this article, we review the evidence for intracavernosal injections of platelet-rich plasma (PRP) in the treatment of ED.<\/jats:p>","DOI":"10.3389\/frph.2022.944765","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T14:57:33Z","timestamp":1660661853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence"],"prefix":"10.3389","volume":"4","author":[{"given":"Eleni","family":"Anastasiadis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razna","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Khizar","family":"Khoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tet","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.amjmed.2006.06.010","article-title":"Prevalence and risk factors for erectile dysfunction in the US","volume":"120","author":"Selvin","year":"2007","journal-title":"Am J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e13384","DOI":"10.1111\/ijcp.13384","article-title":"The association of erectile dysfunction with productivity and absenteeism in eight countries globally","volume":"73","author":"Goldstein","year":"2019","journal-title":"Int J Clin Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/j.1743-6109.2007.00765.x","article-title":"Importance of and satisfaction with sex among men and women worldwide: results of the global better sex survey","volume":"5","author":"Mulhall","year":"2008","journal-title":"J Sex Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.urology.2004.06.055","article-title":"Sexual behavior and sexual dysfunctions after age 40: the global study of sexual attitudes and behaviors","volume":"64","author":"Nicolosi","year":"2004","journal-title":"Urology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/bju.14813","article-title":"The global prevalence of erectile dysfunction: a review","volume":"124","author":"Kessler","year":"2019","journal-title":"BJU Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrurol.2018.20","article-title":"Sexual dysfunction and male infertility","volume":"15","author":"Lotti","year":"2018","journal-title":"Nat Rev Urol."},{"key":"B7","volume-title":"EAU Guidelines: Sexual and Reproductive Health","author":"Salonia","year":"2022"},{"key":"B8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/jsm.12344","article-title":"Health-related characteristics and unmet needs of men with erectile dysfunction: a survey in five European Countries","volume":"11","author":"Jannini","year":"2014","journal-title":"J Sex Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.sxmr.2019.06.008","article-title":"Epidemiology update of erectile dysfunction in eight countries with high burden","volume":"8","author":"Li","year":"2020","journal-title":"Sex Med Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.eururo.2006.07.020","article-title":"Phosphodiesterase type 5 inhibitors: the day after","volume":"51","author":"Hatzimouratidis","year":"2007","journal-title":"Eur Urol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2147\/RRU.S283097","article-title":"The quality of life and economic burden of erectile dysfunction","volume":"13","author":"Elterman","year":"2021","journal-title":"Res Rep Urol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1743-6109.2005.00118.x","article-title":"Sexual experience of female partners of men with erectile dysfunction: the female experience of men's attitudes to life events and sexuality (females) study","volume":"2","author":"Fisher","year":"2005","journal-title":"J Sex Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrurol.2015.315","article-title":"The role of the sexual partner in managing erectile dysfunction","volume":"13","author":"Li","year":"2016","journal-title":"Nat Rev Urol."},{"key":"B14","first-page":"12","article-title":"Towards more objectivity in diagnosis and management of male infertility. results of a world health organization multicenter study","volume":"7","year":"1987","journal-title":"Int J Androl."},{"key":"B15","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat Rev Dis Prim."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00008505-200110000-00002","article-title":"Platelet-rich plasma (PRP): what is PRP and what is not PRP?","volume":"10","author":"Marx","year":"2001","journal-title":"Implant Dent."},{"key":"B17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1159\/000477353","article-title":"Review of platelet-rich plasma: history, biology, mechanism of action, and classification","volume":"41","author":"Alves","year":"2018","journal-title":"Skin Append Disord."},{"key":"B18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13019-016-0452-9","article-title":"Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients","volume":"11","author":"Patel","year":"2016","journal-title":"J Cardiothorac Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/14651858.CD006899.pub3","article-title":"Autologous platelet-rich plasma for treating chronic wounds","volume":"5","author":"Martinez-Zapata","year":"2016","journal-title":"Cochr Database Syst Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/14651858.CD010071.pub3","article-title":"Platelet-rich therapies for musculoskeletal soft tissue injuries","volume":"4","author":"Moraes","year":"2014","journal-title":"Cochr Database Syst Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.jaad.2020.07.006","article-title":"Evaluation of platelet-rich plasma as treatment for androgenetic alopecia: a randomized controlled trial","volume":"83","author":"Shapiro","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.arthro.2016.09.024","article-title":"Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials","volume":"33","author":"Dai","year":"2017","journal-title":"Arthroscopy"},{"key":"B23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/aja.2008.37","article-title":"The effect of platelet-rich plasma on cavernous nerve regeneration in a rat model","volume":"11","author":"Ding","year":"2009","journal-title":"Asian J Androl."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1111\/j.1743-6109.2012.02881.x","article-title":"The neuroprotective effect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model","volume":"9","author":"Wu","year":"2012","journal-title":"J Sex Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e67303","DOI":"10.1371\/journal.pone.0067303","article-title":"HGF mediates the anti-inflammatory effects of PRP on injured tendons","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS ONE."},{"key":"B26","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fnins.2018.00252","article-title":"Therapeutic effect of platelet-rich plasma in rat spinal cord injuries","volume":"12","author":"Chen","year":"2018","journal-title":"Front Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"E294","DOI":"10.1002\/term.1806","article-title":"Optimization of platelet-rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model","volume":"10","author":"Wu","year":"2016","journal-title":"J Tissue Eng Regen Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.jsxm.2020.12.016","article-title":"CXCL5 cytokine is a major factor in platelet-rich plasma's preservation of erectile function in rats after bilateral cavernous nerve injury","volume":"18","author":"Wu","year":"2021","journal-title":"J Sex Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jfma.2021.01.019","article-title":"Dual effect of chitosan activated platelet rich plasma (cPRP) improved erectile function after cavernous nerve injury","volume":"121","author":"Wu","year":"2022","journal-title":"J Formos Med Assoc."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e582","DOI":"10.1016\/j.juro.2018.02.1408","article-title":"MP43-09 effects of platelet rich plasma on improving erectile dysfunction in streptozotocin-induced diabetic rats","volume":"199","author":"Liao","year":"2018","journal-title":"J Urol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.3390\/ijms23063017","article-title":"Intracavernous injection of platelet-rich plasma therapy enhances erectile function and decreases the mortality rate in streptozotocin-induced diabetic rats","volume":"23","author":"Liao","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.2337\/db19-2240-PUB","article-title":"2240-PUB: healing effect of intracavernosal platelet-rich plasma transplantation in the presence of clopidogrel (plavix) on the progression of erectile dysfunction in streptozotocin-induced diabetic rats","volume":"68","author":"Gur","year":"2019","journal-title":"Diabetes."},{"key":"B33","doi-asserted-by":"publisher","first-page":"100317","DOI":"10.1016\/j.esxm.2020.100317","article-title":"Intracavernous injection of autologous platelet-rich plasma ameliorates hyperlipidemia-associated erectile dysfunction in a rat model","volume":"9","author":"Huang","year":"2021","journal-title":"Sex Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.jsxm.2021.03.008","article-title":"Platelet-rich plasma (PRP) improves erectile function: a double-blind, randomized, placebo-controlled clinical trial","volume":"18","author":"Poulios","year":"2021","journal-title":"J Sex Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.jsxm.2019.03.228","article-title":"PO-01-091 platelet rich plasma penile rejuvenation as a treatment for erectile dysfunction: an update","volume":"16","author":"Alkhayal","year":"2019","journal-title":"J Sex Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1016\/j.jsxm.2016.12.134","article-title":"146 the efficacy of platelet-rich plasma (PRP) as a supplemental therapy for the treatment of erectile dysfunction (ED) : initial outcomes","volume":"14","author":"Banno","year":"2017","journal-title":"J Sex Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4111\/icu.2018.59.1.61","article-title":"Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions","volume":"59","author":"Matz","year":"2018","journal-title":"Investig Clin Urol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"100313","DOI":"10.1016\/j.esxm.2020.100313","article-title":"Early clinical results of the tolerability, safety, and efficacy of autologous platelet-rich plasma administration in erectile dysfunction","volume":"9","author":"Ta\u015f","year":"2021","journal-title":"Sex Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e14162","DOI":"10.1111\/and.14162","article-title":"Smoking status and the baseline international index of erectile function score can predict satisfactory response to platelet-rich plasma in patients with erectile dysfunction: a prospective pilot study","volume":"53","author":"Zaghloul","year":"2021","journal-title":"Andrologia."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e14197","DOI":"10.1111\/and.14197","article-title":"Comparison of the efficacy of low-intensity shock wave therapy and its combination with platelet-rich plasma in patients with erectile dysfunction","volume":"53","author":"Geyik","year":"2021","journal-title":"Andrologia."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e1622","DOI":"10.1016\/S1569-9056(19)","article-title":"Effectiveness and safety of Platelet rich Plasma (PrP) cavernosal injections plus external shock wave treatment for penile erectile dysfunction: first results from a prospective, randomized, controlled, interventional study","volume":"18","author":"Ruffo","year":"2019","journal-title":"Eur Urol Suppl."},{"key":"B42","first-page":"76","article-title":"The effectiveness of intracavernous autologous platelet-rich plasma in the treatment of erectile dysfunction","volume":"4","author":"Chalyj","year":"2015","journal-title":"Urologiia"},{"key":"B43","doi-asserted-by":"publisher","first-page":"S176","DOI":"10.1016\/j.jsxm.2020.04.170","article-title":"P-02-16 combined platelet-rich plasma and shockwave therapy in erectile dysfunction treatment","volume":"17","author":"Epifanova","year":"2020","journal-title":"J Sex Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1016\/j.jsxm.2019.03.164","article-title":"HP-09-006 first results of platelet-rich plasma and low intensity extracorporeal shockwave combined therapy for erectile dysfunction","volume":"16","author":"Epifanova","year":"2019","journal-title":"J Sex Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4103\/UROS.UROS_22_21","article-title":"short term follow up for intracavernosal injection of platelet rich plasma for the treatment of erectile dysfunction","volume":"32","author":"Shin-Mei","year":"2021","journal-title":"Urol Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.sxmr.2019.02.002","article-title":"Platelet-rich plasma therapy for male sexual dysfunction: myth or reality?","volume":"8","author":"Epifanova","year":"2020","journal-title":"Sex Med Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.1016\/j.jsxm.2020.04.048","article-title":"PS-5-3 Management of erectile dysfunction using a combination treatment of low-intensity shock waves (LISW) and platelet rich plasma (PRP) intracavernosal injections","volume":"17","author":"Ruffo","year":"2020","journal-title":"J Sex Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"S158","DOI":"10.1016\/j.jsxm.2020.04.120","article-title":"HP-3-1 platelet rich plasma and low-intensity pulsed ultrasound combination in erectile dysfunction treatment","volume":"17","author":"Zasieda","year":"2020","journal-title":"J Sex Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e769","DOI":"10.1016\/S2666-1683(20)33095-0","article-title":"492\u2014Intraoperative application of platelet-rich plasma to the neurovascular bundles during radical prostatectomy: a prospective clinical trial","volume":"19","author":"Juvet","year":"2020","journal-title":"Eur Urol Open Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e14421","DOI":"10.1111\/and.14421","article-title":"Assessment of the intracavernosal injection platelet-rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non-responding to on-demand oral PDE5 inhibitors","volume":"17","author":"Zaghloul","year":"2022","journal-title":"Andrologia."},{"key":"B51","unstructured":"SalamancaJIM\n          Clinical Trial to Evaluate the Efficacy of Intracavernosal Infusion of PRP vs. PPP for the Erectile Dysfunction (PRePED)2020"},{"key":"B52","unstructured":"DeibertC\n          The Role of Platelet Rich Plasma for Erectile Dysfunction2021"},{"key":"B53","unstructured":"RamasamyR\n            MastersonT\n          33529814Safety Efficacy of Autologous Platelet-Rich Plasma for Erectile Dysfunction2021"},{"key":"B54","unstructured":"RamasamyR\n            MolinaM\n          Shockwave Therapy Platelet Rich Plasma for the Treatment of Erectile Dysfunction Cocktail2021"},{"key":"B55","unstructured":"LiuMC\n          A Clinical Study of the Combined Treatment of Platelet-rich Plasma Low-intensity Extracorporeal Shockwave Therapy on Erectile Dysfunction2020"},{"key":"B56","doi-asserted-by":"crossref","unstructured":"BroderickG\n          PRP for the Treatment of Erectile Dysfunction (ED)2021","DOI":"10.1093\/med\/9780190655341.003.0043"}],"container-title":["Frontiers in Reproductive Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frph.2022.944765\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T14:57:39Z","timestamp":1660661859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frph.2022.944765\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":56,"alternative-id":["10.3389\/frph.2022.944765"],"URL":"https:\/\/doi.org\/10.3389\/frph.2022.944765","relation":{},"ISSN":["2673-3153"],"issn-type":[{"value":"2673-3153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"article-number":"944765"}}