{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:39:41Z","timestamp":1785116381853,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Oocyte cryopreservation is an established technique for fertility preservation in women diagnosed with cancer. However, some clinical scenarios may preclude the commonly used transvaginal approach to oocyte retrieval. In such cases, a laparoscopic approach may be required. Here, we report the feasibility and safety of a combined laparoscopic and transvaginal approach for oocyte retrieval in a woman with vaginal recurrence of cervical adenocarcinoma. This approach allowed for oocyte cryopreservation prior to cancer treatment, representing a novel application in this clinical context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 31-year-old woman with endocervical adenocarcinoma underwent laparoscopic radical hysterectomy and pelvic lymph node dissection. She presented with vaginal recurrence and was referred for fertility preservation by oocyte cryopreservation before chemotherapy and radiotherapy\/brachytherapy. Ovarian stimulation was initiated with a gonadotropin antagonist protocol combined with aromatase inhibitors, and oocyte retrieval was performed with a combined laparoscopic and transvaginal approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 18 oocytes were retrieved and 10 mature oocytes were cryopreserved. Peritoneal fluid cytology was negative for malignancy. The patient underwent chemotherapy and radiotherapy\/brachytherapy and was disease-free after oocyte retrieval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined laparoscopic and transvaginal approach for oocyte retrieval emerges as a practical and efficacious method for fertility preservation in cases of cervical adenocarcinoma with vaginal recurrence. Further comprehensive studies are warranted to establish the reproducibility, safety, and long-term outcomes associated with this innovative approach.<\/jats:p><\/jats:sec>","DOI":"10.3389\/frph.2023.1295939","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T05:55:52Z","timestamp":1704693352000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility and safety of combined laparoscopic and transvaginal oocyte retrieval in a woman with vaginal recurrence of cervical adenocarcinoma: a case report"],"prefix":"10.3389","volume":"5","author":[{"given":"Caroline","family":"Ingold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Andrea","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Parente","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Sadalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Bedoschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"B1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/ijgo.13865","article-title":"Cancer of the cervix uteri: 2021 update","volume":"155","author":"Bhatla","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"948298","DOI":"10.3389\/fonc.2022.948298","article-title":"Radical surgery for stage IB2\/IIA2 cervical cancer: a large retrospective study","volume":"12","author":"Zhou","year":"2022","journal-title":"Front Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.2217\/fon-2016-0176","article-title":"Chemotherapy-induced damage to ovary: mechanisms and clinical impact","volume":"12","author":"Bedoschi","year":"2016","journal-title":"Future Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.23736\/S0031-0808.18.03494-8","article-title":"Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary","volume":"61","author":"Bedoschi","year":"2019","journal-title":"Panminerva Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.fertnstert.2019.09.013","article-title":"Electronic address: asrm@asrm.org. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion","volume":"112","year":"2019","journal-title":"Fertil Steril"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1093\/humrep\/dex218","article-title":"Update on fertility preservation from the Barcelona international society for fertility preservation-ESHRE-ASRM 2015 expert meeting: indications, results and future perspectives","volume":"32","author":"Martinez","year":"2017","journal-title":"Hum Reprod"},{"key":"B8","doi-asserted-by":"publisher","first-page":"hoz025","DOI":"10.1093\/hropen\/hoz025","article-title":"Recommendations for good practice in ultrasound: oocyte pick up\u2020","volume":"2019","author":"D'Angelo","year":"2019","journal-title":"Hum Reprod Open"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/j.fertnstert.2011.01.006","article-title":"Transabdominal follicular aspiration for oocyte retrieval in patients with ovaries inaccessible by transvaginal ultrasound","volume":"95","author":"Barton","year":"2011","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1056\/NEJMoa1806395","article-title":"Minimally invasive versus abdominal radical hysterectomy for cervical cancer","volume":"379","author":"Ramirez","year":"2018","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00404-017-4595-2","article-title":"Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part II: fertility preservation techniques","volume":"297","author":"von Wolff","year":"2018","journal-title":"Arch Gynecol Obstet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s10815-010-9429-0","article-title":"Ovarian stimulation during the luteal phase for fertility preservation of cancer patients: case reports and review of the literature","volume":"27","author":"Bedoschi","year":"2010","journal-title":"J Assist Reprod Genet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1007\/s10815-023-02882-0","article-title":"Outcomes of random-start letrozole protocol with PGT-A in women with breast cancer undergoing fertility preservation","volume":"40","author":"Turan","year":"2023","journal-title":"J Assist Reprod Genet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10815-014-0248-6","article-title":"Triggering final oocyte maturation with gonadotropin-releasing hormone agonist (GnRHa) versus human chorionic gonadotropin (hCG) in breast cancer patients undergoing fertility preservation: an extended experience","volume":"31","author":"Reddy","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"26334941231196545","DOI":"10.1177\/26334941231196545","article-title":"Risk of ovarian hyperstimulation syndrome in women with malignancies undergoing treatment with long-acting gonadotropin-releasing hormone agonist after controlled ovarian hyperstimulation for fertility preservation: a systematic review","volume":"17","author":"Ingold","year":"2023","journal-title":"Ther Adv Reprod Health"},{"key":"B16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/1933719117728800","article-title":"Ovarian stimulation in patients with cancer: impact of letrozole and BRCA mutations on fertility preservation cycle outcomes","volume":"25","author":"Turan","year":"2018","journal-title":"Reprod Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ygyno.2013.04.009","article-title":"Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer","volume":"130","author":"Zighelboim","year":"2013","journal-title":"Gynecol Oncol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0028-2243(87)90047-5","article-title":"Follicular aspiration for in vitro fertilization: sonographically guided transvaginal versus laparoscopic approach","volume":"26","author":"Deutinger","year":"1987","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.fertnstert.2015.10.026","article-title":"Successful elective and medically indicated oocyte vitrification and warming for autologous in vitro fertilization, with predicted birth probabilities for fertility preservation according to number of cryopreserved oocytes and age at retrieval","volume":"105","author":"Doyle","year":"2016","journal-title":"Fertil Steril"},{"key":"B20","year":""}],"container-title":["Frontiers in Reproductive Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frph.2023.1295939\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T05:55:55Z","timestamp":1704693355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frph.2023.1295939\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":20,"alternative-id":["10.3389\/frph.2023.1295939"],"URL":"https:\/\/doi.org\/10.3389\/frph.2023.1295939","relation":{},"ISSN":["2673-3153"],"issn-type":[{"value":"2673-3153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,8]]},"article-number":"1295939"}}