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Physical activity is widely recognized to improve overall well-being, but engaging in excessive exercise might potentially lead to male infertility due to the negative impact on hypothalamic-pituitary-testicular (HPT) function, increased oxidative stress, and the presence of chronic inflammation. Infertility might result from the fundamental factors that induce a decline in testosterone production and semen quality. Physical activity has the potential strategy to enhance male fertility in cases of infertility caused by obesity and diabetes. Exercise enhances spermatogenesis and semen quality in lifestyle-induced infertility by increasing testicular antioxidant defense, reducing pro-inflammatory cytokines, and promoting steroidogenesis.<\/jats:p>","DOI":"10.3389\/frph.2024.1423916","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T01:10:18Z","timestamp":1721265018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring the dynamics of exercise intensity on male fertility and reproductive health: advancements and implications for fertility research"],"prefix":"10.3389","volume":"6","author":[{"given":"Navid","family":"Abedpoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Taghian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Hajibabaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1677\/JOE-08-0477","article-title":"The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus-pituitary-testis axis, and semen quality: a randomized controlled study","volume":"200","author":"Safarinejad","year":"2009","journal-title":"J Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.freeradbiomed.2004.01.012","article-title":"Endurance exercise results in DNA damage as detected by the comet assay","volume":"36","author":"Mastaloudis","year":"2004","journal-title":"Free Radical Biology and Medicine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1055\/s-2005-872906","article-title":"Reproductive profile of physically active men after exhaustive endurance exercise","volume":"27","author":"Vaamonde","year":"2006","journal-title":"Int J Sports Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e13183","DOI":"10.1111\/and.13183","article-title":"Effects of branched-chain amino acid supplementation and\/or aerobic exercise on mouse sperm quality and testosterone production","volume":"51","author":"Bahadorani","year":"2019","journal-title":"Andrologia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e14433","DOI":"10.1111\/and.14433","article-title":"Influence of physical activity on male fertility","volume":"54","author":"Minas","year":"2022","journal-title":"Andrologia"},{"key":"B6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1097\/JSM.0b013e31823f310a","article-title":"Correlation between seminal oxidative stress biomarkers and antioxidants with sperm DNA damage in elite athletes and recreationally active men","volume":"22","author":"Tartibian","year":"2012","journal-title":"Clin J Sport Med"},{"key":"B7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4939-1040-3_4","article-title":"The impact of physical exercise on male fertility","volume-title":"Male Infertility: A Complete Guide to Lifestyle and Environmental Factors","author":"Vaamonde Martin","year":"2014"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/3071658","article-title":"Effect of different exercise loads on testicular oxidative stress and reproductive function in obese male mice","volume":"2020","author":"Yi","year":"2020","journal-title":"Oxid Med Cell Longevity"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.3390\/antiox11101874","article-title":"Effects of moderate-intensity continuous training and high-intensity interval training on testicular oxidative stress, apoptosis and m6A Methylation in obese male mice","volume":"11","author":"Xu","year":"2022","journal-title":"Antioxidants"},{"key":"B10","doi-asserted-by":"publisher","first-page":"151844","DOI":"10.1016\/j.acthis.2022.151844","article-title":"Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases","volume":"124","author":"Abedpoor","year":"2022","journal-title":"Acta Histochem"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e13617","DOI":"10.1111\/and.13617","article-title":"Obesity and male infertility: mechanisms and management","volume":"53","author":"Leisegang","year":"2021","journal-title":"Andrologia"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-4755-8-24","article-title":"Does weight loss improve semen quality and reproductive hormones? 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