{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:24:09Z","timestamp":1774430649999,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Corifollitropin alfa (CFA) is a long-acting recombinant follicle-stimulating hormone that reduces injection burden during controlled ovarian stimulation (COS). While its clinical efficacy has been demonstrated, its potential influence on early embryo development assessed by time-lapse morphokinetics remains insufficiently explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed embryos derived from COS using either CFA or daily follitropin \u03b2. A total of 561 embryos from 99 CFA-stimulated patients and 3,116 embryos from 481 follitropin \u03b2-stimulated patients were included. Embryos were cultured in a time-lapse incubator, and morphokinetic parameters including pronuclear fading (tPNf) and early cleavage stages from t2 to t8 were recorded. Linear mixed-effects models were applied to account for repeated measurements per patient. Clinical outcomes including fertilization, biochemical, clinical and live birth rates were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients receiving CFA were older and showed lower anti-M\u00fcllerian hormone levels and higher baseline FSH concentrations, indicating a reduced ovarian reserve. No significant differences were observed between groups in morphokinetic parameters, including cleavage timings (t2\u2013t8), cleavage synchronicity, or early developmental progression (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05). The numbers of retrieved oocytes, metaphase II oocytes, and fertilization rates were comparable between stimulation protocols. Biochemical pregnancy rates were lower in the CFA group; however, clinical pregnancy and live birth rates did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Controlled ovarian stimulation with CFA does not appear to affect early embryo morphokinetics as assessed by time-lapse imaging. Despite differences in baseline patient characteristics, CFA was associated with comparable embryo developmental dynamics and live birth outcomes compared with daily follitropin\n                      <jats:italic>\u03b2<\/jats:italic>\n                      stimulation. These findings suggest that CFA may represent an alternative COS strategy in routine clinical practice without apparent detrimental effects on early embryo development; however, they should be interpreted with caution due to the observational design.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frph.2026.1787644","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:52:42Z","timestamp":1774421562000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of corifollitropin alfa on embryo morphokinetics and fertility treatment outcome"],"prefix":"10.3389","volume":"8","author":[{"given":"Gregor","family":"Weiss","sequence":"first","affiliation":[{"name":"Das Kinderwunsch Institut Schenk GmbH","place":["Dobl, Austria"]},{"name":"Gottfried Schatz Research Center, Division of Cell Biology, Histology & Embryology, Medical University of Graz","place":["Graz, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Groselj-Strele","sequence":"additional","affiliation":[{"name":"Core Facility Computational Bioanalytics, Medical University of Graz","place":["Graz, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Eberhard","sequence":"additional","affiliation":[{"name":"Core Facility Computational Bioanalytics, Medical University of Graz","place":["Graz, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Blauensteiner","sequence":"additional","affiliation":[{"name":"Das Kinderwunsch Institut Schenk GmbH","place":["Dobl, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schenk","sequence":"additional","affiliation":[{"name":"Das Kinderwunsch Institut Schenk GmbH","place":["Dobl, Austria"]},{"name":"Department of Obstetrics and Gynecology, Medical University of Graz","place":["Graz, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"CD009577","DOI":"10.1002\/14651858.CD009577.pub3","article-title":"Long-acting FSH versus daily FSH for women undergoing assisted reproduction","volume":"2015","author":"Pouwer","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1239175","DOI":"10.3389\/frph.2023.1239175","article-title":"Conventional ovarian stimulation vs. delayed single dose corifollitropin alfa ovarian stimulation in oocyte donors: a prospective randomized study. 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