{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:38:53Z","timestamp":1793137133895,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010566","name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Advanced maternal age (AMA) and assisted reproductive technologies (ART) are becoming more common and are linked with higher obstetric and perinatal risks. Genomic tools and real-world data (RWD) are transforming risk prediction and care strategies, yet their application to the AMA\u2009+\u2009ART setting remains uneven.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize recent evidence on risks associated with AMA and ART, incorporate insights from reproductive genomics and RWD, and discuss their implications for clinical care and guideline development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative review of cohort studies, systematic reviews, and meta-analyses, supplemented by focused analyses of genomic approaches: expanded carrier screening, clinical exome sequencing, preimplantation genetic testing for monogenic disorders (PGT-M) and aneuploidy (PGT-A), emerging non-invasive PGT, and pharmacogenomics, as well as RWD infrastructures such as registries, EHR datasets, and trusted research environments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Maternal age (\u226540 years) increases miscarriage, gestational diabetes, hypertensive disorders, placental abnormalities, cesarean delivery, preterm birth, stillbirth, and NICU admissions. ART independently raises risks of preeclampsia, placenta previa, preterm birth, low birthweight, cesarean delivery, and neonatal complications, including in singleton. Combined AMA\u2009+\u2009ART may produce additive or synergistic effects. Donor oocytes reduces miscarriage risk but may elevate preeclampsia risk via immunologic mechanisms. Genomic technologies enable the identification of infertility-related variants, prevention of genetic conditions, individualized ovarian stimulation, and AI-assisted embryo selection. RWD enhances evidence by capturing diverse populations, supporting comparative and long-term analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pregnancies from AMA\u2009+\u2009ART should be managed as high risk. Integration of genomics technologies and RWD can support predictive, personalized care and inform urgently needed consensus guidelines<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frph.2026.1787867","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:54:15Z","timestamp":1772088855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence"],"prefix":"10.3389","volume":"8","author":[{"given":"C.","family":"M\u00e9ndez-Vidal","sequence":"first","affiliation":[{"name":"Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville","place":["Seville, Spain"]},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Seville, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"VIDA Recoletas","place":["Seville, Spain"]},{"name":"Department of Surgery, University of Seville","place":["Seville, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dom\u00ednguez-Moreno","sequence":"additional","affiliation":[{"name":"Department of Materno-Fetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville","place":["Seville, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Garc\u00eda-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Seville","place":["Seville, Spain"]},{"name":"Department of Materno-Fetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville","place":["Seville, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dopazo","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville","place":["Seville, Spain"]},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Seville, Spain"]},{"name":"Andalusian Platform for Computational Medicine, Andalusian Public Foundation Progress and Health-FPS","place":["Seville, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Anti\u00f1olo","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Seville, Spain"]},{"name":"Department of Surgery, University of Seville","place":["Seville, Spain"]},{"name":"Department of Materno-Fetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville","place":["Seville, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.whi.2020.08.008","article-title":"Adverse birth outcomes among women of advanced maternal age with and without health conditions in Maryland","volume":"31","author":"Berger","year":"2021","journal-title":"Womens Health Issues"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1111\/jog.14790","article-title":"Pregnancy outcomes among Asian Americans of advanced maternal age, 1992\u20132018","volume":"47","author":"Dongarwar","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1053\/j.semperi.2017.07.001","article-title":"In Vitro fertilization and adverse obstetric and perinatal outcomes","volume":"41","author":"Sullivan-Pyke","year":"2017","journal-title":"Semin Perinatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bpobgyn.2020.07.005","article-title":"Advanced maternal age and adverse pregnancy outcomes","volume":"70","author":"Frick","year":"2021","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.20344\/amp.11057","article-title":"Advanced maternal age: adverse outcomes of pregnancy, A meta-analysis","volume":"32","author":"Pinheiro","year":"2019","journal-title":"Acta Med Port"},{"key":"B6","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1089\/jwh.2020.8860","article-title":"Clinical outcomes in high-risk pregnancies due to advanced maternal age","volume":"30","author":"Correa-de-Araujo","year":"2021","journal-title":"J Womens Health (Larchmt)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"751","DOI":"10.2147\/IJWH.S283216","article-title":"Management of pregnancy in women of advanced maternal age: improving outcomes for mother and baby","volume":"13","author":"Glick","year":"2021","journal-title":"Int J Womens Health"},{"key":"B8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.tjog.2020.11.018","article-title":"Advanced maternal age and adverse pregnancy outcomes: a cohort study","volume":"60","author":"Guarga Montori","year":"2021","journal-title":"Taiwan J Obstet Gynecol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"5696","DOI":"10.3390\/jcm12175696","article-title":"The impact of advanced maternal age on pregnancy outcomes: a retrospective multicenter study","volume":"12","author":"Hochler","year":"2023","journal-title":"J Clin Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.18502\/ijph.v51i5.9421","article-title":"Do hypertensive disorders of pregnancy and abnormal placentation mediate the association between advanced maternal age and adverse perinatal outcomes?","volume":"51","author":"Li","year":"2022","journal-title":"Iran J Public Health"},{"key":"B11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12884-020-2740-6","article-title":"Advanced maternal age pregnancy and its adverse obstetrical and perinatal outcomes in Ayder comprehensive specialized hospital, northern Ethiopia, 2017: a comparative cross-sectional study","volume":"20","author":"Mehari","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s00404-024-07678-w","article-title":"Advanced maternal age (AMA) and pregnancy: a feasible but problematic event","volume":"310","author":"Sparic","year":"2024","journal-title":"Arch Gynecol Obstet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.xfnr.2022.06.003","article-title":"Assisted reproductive technology or infertility: what underlies adverse outcomes? Lessons from the Massachusetts outcome study of assisted reproductive technology","volume":"3","author":"Stern","year":"2022","journal-title":"F S Rev"},{"key":"B14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.fertnstert.2018.04.032","article-title":"Factors associated with increased odds of cesarean delivery in ART pregnancies","volume":"110","author":"Stern","year":"2018","journal-title":"Fertil Steril"},{"key":"B15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1523-536X.2010.00405.x","article-title":"Population-based study of cesarean section after in vitro fertilization in Australia","volume":"37","author":"Sullivan","year":"2010","journal-title":"Birth"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1055\/a-2157-3106","article-title":"Risk of preterm delivery in very advanced maternal age parturients utilizing in vitro fertilization","volume":"41","author":"Newman","year":"2024","journal-title":"Am J Perinatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1089\/whr.2023.0178","article-title":"In Vitro fertilization\/intracytoplasmic sperm injection with autologous oocytes in healthy women of advanced maternal age: a comparative study investigating obstetric and perinatal outcomes through single versus double embryo transfer","volume":"5","author":"Reinolds","year":"2024","journal-title":"Womens Health Rep (New Rochelle)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"100885","DOI":"10.1016\/j.ajogmf.2023.100885","article-title":"Pregnancy outcomes at maternal age over 45 years: a systematic review and meta-analysis","volume":"5","author":"Sugai","year":"2023","journal-title":"Am J Obstet Gynecol MFM"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e35875","DOI":"10.7759\/cureus.35875","article-title":"Recent Status of pregnancies at an advanced maternal age at a Japanese perinatal center","volume":"15","author":"Suzuki","year":"2023","journal-title":"Cureus"},{"key":"B20","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.molmed.2020.12.008","article-title":"Strategies to identify genetic variants causing infertility","volume":"27","author":"Ding","year":"2021","journal-title":"Trends Mol Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/aogs.70084","article-title":"Perinatal outcomes in pregnancies with very and extremely advanced maternal age: an Italian multicenter retrospective cohort study","volume":"105","author":"Ammar","year":"2026","journal-title":"Acta Obstet Gynecol Scand"},{"key":"B22","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/aogs.14064","article-title":"Adverse maternal and perinatal pregnancy outcomes related to very advanced maternal age in Primigravida and Multigravida in The Netherlands: a population-based cohort","volume":"100","author":"Rademaker","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.2147\/IJWH.S538128","article-title":"Pregnancy outcomes following assisted reproductive technology in advanced maternal age primiparous women: a retrospective cohort study","volume":"17","author":"Deng","year":"2025","journal-title":"Int J Womens Health"},{"key":"B24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.fertnstert.2025.05.150","article-title":"Advanced maternal age was associated with an annual decline in reproductive success despite use of donor oocytes: a retrospective study","volume":"124","author":"Sebastian-Leon","year":"2025","journal-title":"Fertil Steril"},{"key":"B25","doi-asserted-by":"publisher","first-page":"108320","DOI":"10.1016\/j.mrrev.2020.108320","article-title":"Mechanisms of oocyte aneuploidy associated with advanced maternal age","volume":"785","author":"Mikwar","year":"2020","journal-title":"Mutat Res Rev Mutat Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1093\/humrep\/dead201","article-title":"Aneuploidy in oocytes from women of advanced maternal age: analysis of the causal meiotic errors and impact on embryo development","volume":"38","author":"Verdyck","year":"2023","journal-title":"Hum Reprod"},{"key":"B27","doi-asserted-by":"publisher","first-page":"102292","DOI":"10.1016\/j.arr.2024.102292","article-title":"The impact of maternal age on aneuploidy in oocytes: reproductive consequences, molecular mechanisms, and future directions","volume":"97","author":"Huang","year":"2024","journal-title":"Ageing Res Rev"},{"key":"B28","doi-asserted-by":"publisher","first-page":"9677","DOI":"10.1038\/s41598-017-09814-w","article-title":"Placental dysfunction underlies increased risk of fetal growth restriction and stillbirth in advanced maternal age women","volume":"7","author":"Lean","year":"2017","journal-title":"Sci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1530\/JME-17-0243","article-title":"Decidual cell regulation of trophoblast is altered in pregnancies at risk of pre-eclampsia","volume":"60","author":"James-Allan","year":"2018","journal-title":"J Mol Endocrinol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/cmi.2014.46","article-title":"Immune cells in term and preterm labor","volume":"11","author":"Gomez-Lopez","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","volume":"31","author":"Erlebacher","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/cei.13437","article-title":"The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study","volume":"201","author":"Levenson","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e169836","DOI":"10.1172\/jci.insight.169836","article-title":"Treg cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice","volume":"10","author":"Hosking","year":"2024","journal-title":"JCI Insight"},{"key":"B34","doi-asserted-by":"publisher","first-page":"115314","DOI":"10.1016\/j.intimp.2025.115314","article-title":"Immunological dysregulation in preeclampsia: pathogenesis and clinical implications","volume":"163","author":"Qin","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1093\/humupd\/dmq017","article-title":"Clinical and immunologic aspects of egg donation pregnancies: a systematic review","volume":"16","author":"van der Hoorn","year":"2010","journal-title":"Hum Reprod Update"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/j.fertnstert.2013.01.128","article-title":"Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study","volume":"99","author":"Malchau","year":"2013","journal-title":"Fertil Steril"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s00404-017-4616-1","article-title":"Increased incidence of preeclampsia in mothers of advanced age conceiving by oocyte donation","volume":"297","author":"Dior","year":"2018","journal-title":"Arch Gynecol Obstet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12884-019-2291-x","article-title":"Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis","volume":"19","author":"Almasi-Hashiani","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"key":"B39","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/1471-0528.14257","article-title":"Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis","volume":"124","author":"Storgaard","year":"2017","journal-title":"BJOG"},{"key":"B40","doi-asserted-by":"publisher","first-page":"102167","DOI":"10.1016\/j.jogoh.2021.102167","article-title":"Frozen embryo transfer and preeclampsia risk","volume":"50","author":"Severino","year":"2021","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"B41","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1161\/HYPERTENSIONAHA.118.12046","article-title":"Absent or excessive corpus Luteum number is associated with altered maternal vascular health in early pregnancy","volume":"73","author":"von Versen-Hoynck","year":"2019","journal-title":"Hypertension"},{"key":"B42","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/15592294.2019.1646572","article-title":"Epigenetic changes and assisted reproductive technologies","volume":"15","author":"Mani","year":"2020","journal-title":"Epigenetics"},{"key":"B43","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/humupd\/dmaa010","article-title":"Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis","volume":"26","author":"du Fosse","year":"2020","journal-title":"Hum Reprod Update"},{"key":"B44","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nrendo.2009.177","article-title":"The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism","volume":"5","author":"Bianco","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1056\/NEJMc1310150","article-title":"Mutations in HFM1 in recessive primary ovarian insufficiency","volume":"370","author":"Wang","year":"2014","journal-title":"N Engl J Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/MOU.0000000000001287","article-title":"Genetics of male infertility","volume":"35","author":"Corsini","year":"2025","journal-title":"Curr Opin Urol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/s41588-025-02156-8","article-title":"Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum","volume":"57","author":"Venkatesh","year":"2025","journal-title":"Nat Genet"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1038\/s43587-024-00733-w","article-title":"Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring","volume":"4","author":"Benonisdottir","year":"2024","journal-title":"Nat Aging"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/molbev\/msw005","article-title":"267 Spanish exomes reveal population-specific differences in disease-related genetic variation","volume":"33","author":"Dopazo","year":"2016","journal-title":"Mol Biol Evol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"D1130","DOI":"10.1093\/nar\/gkaa794","article-title":"CSVS, a crowdsourcing database of the Spanish population genetic variability","volume":"49","author":"Pena-Chilet","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e57357","DOI":"10.7759\/cureus.57357","article-title":"Advancements and applications of preimplantation genetic testing in in vitro fertilization: a comprehensive review","volume":"16","author":"Gudapati","year":"2024","journal-title":"Cureus"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s10815-025-03406-8","article-title":"Clinical exome sequencing for carrier screening in assisted reproductive technology and sperm donation","volume":"42","author":"Cai","year":"2025","journal-title":"J Assist Reprod Genet"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s00404-024-07370-z","article-title":"Preimplantation genetic testing in the current era, a review","volume":"309","author":"Tian","year":"2024","journal-title":"Arch Gynecol Obstet"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s10815-025-03416-6","article-title":"IVF success rates in individuals accessing preimplantation genetic testing for monogenic conditions (PGT-M): a single centre retrospective cohort study of 572 IVF cycles","volume":"42","author":"Poulton","year":"2025","journal-title":"J Assist Reprod Genet"},{"key":"B55","doi-asserted-by":"publisher","first-page":"104845","DOI":"10.1016\/j.rbmo.2025.104845","article-title":"The evolution of preimplantation genetic testing: where is the limit?","volume":"50","author":"Capalbo","year":"2025","journal-title":"Reprod Biomed Online"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1111\/andr.13744","article-title":"Preconception carrier screening and preimplantation genetic testing in the infertility management","volume":"13","author":"Caroselli","year":"2025","journal-title":"Andrology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1964","DOI":"10.1002\/jgc4.1964","article-title":"Expanded carrier screening for inherited genetic disease using exome and genome sequencing","volume":"34","author":"Belnap","year":"2025","journal-title":"J Genet Couns"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e100572","DOI":"10.7759\/cureus.100572","article-title":"Importance of preconception reproductive genetic screening in routine clinical care","volume":"18","author":"Basavaraj","year":"2026","journal-title":"Cureus"},{"key":"B59","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/genes17010058","article-title":"Expanded carrier screening: current evidence and future directions in the era of population genomics","volume":"17","author":"Pilenzi","year":"2026","journal-title":"Genes (Basel)"},{"key":"B60","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ejogrb.2024.05.019","article-title":"Current status and future of genomics in fetal and maternal medicine: a scientific review commissioned by European board and college of obstetrics and gynaecology (EBCOG)","volume":"299","author":"O'Brien","year":"2024","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5653\/cerm.2023.06303","article-title":"Genomic aspects in reproductive medicine","volume":"51","author":"Go","year":"2024","journal-title":"Clin Exp Reprod Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s10815-018-1204-7","article-title":"Comprehensive genetic testing for female and male infertility using next-generation sequencing","volume":"35","author":"Patel","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1038\/s41591-025-03543-8","article-title":"Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses","volume":"31","author":"Pujol Gualdo","year":"2025","journal-title":"Nat Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1520919","DOI":"10.3389\/frph.2025.1520919","article-title":"The integration of artificial intelligence in assisted reproduction: a comprehensive review","volume":"7","author":"Kakkar","year":"2025","journal-title":"Front Reprod Health"},{"key":"B65","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12874-022-01768-6","article-title":"Real-world data: a brief review of the methods, applications, challenges and opportunities","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Med Res Methodol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1056\/NEJMsb1609216","article-title":"Real-world evidence\u2014what is it and what can it tell US","volume":"375","author":"Sherman","year":"2016","journal-title":"N Engl J Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e1912869","DOI":"10.1001\/jamanetworkopen.2019.12869","article-title":"Feasibility of using real-world data to replicate clinical trial evidence","volume":"2","author":"Bartlett","year":"2019","journal-title":"JAMA Network Open"},{"key":"B68","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.fertnstert.2022.05.010","article-title":"Comparison of perinatal outcomes after frozen or fresh embryo transfer: separate analyses of singleton, twin, and sibling live births from a linked national in vitro fertilization registry","volume":"118","author":"Raja","year":"2022","journal-title":"Fertil Steril"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1630351","DOI":"10.3389\/fpubh.2025.1630351","article-title":"Ethical and secure evidence generation from region wide clinical data through a collaborative environment for advancing predictive care","volume":"13","author":"Mu\u00f1oyerro-Mu\u00f1iz","year":"2025","journal-title":"Front Public Health"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1101\/2024.12.29.24319724","article-title":"The impact of menopause on hypercholesterolemia and comorbidities: a population-based study","author":"Esteban-Medina","year":"2024","journal-title":"medRxiv"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1101\/2024.07.26.24310994","article-title":"Early prediction of ovarian cancer risk based on real world data","author":"de la Oliva","year":"2024","journal-title":"medRxiv"}],"container-title":["Frontiers in Reproductive Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frph.2026.1787867\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:54:16Z","timestamp":1772088856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frph.2026.1787867\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":71,"alternative-id":["10.3389\/frph.2026.1787867"],"URL":"https:\/\/doi.org\/10.3389\/frph.2026.1787867","relation":{},"ISSN":["2673-3153"],"issn-type":[{"value":"2673-3153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"article-number":"1787867"}}