{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:11:44Z","timestamp":1779343904969,"version":"3.51.4"},"reference-count":194,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In oocyte growth and development, metabolic reprogramming serves as a core process by which cells adjust their metabolic patterns\u2014including glucose metabolism, lipid metabolism, and amino acid metabolism\u2014to adapt to developmental cues, differentiation, and environmental stress. This reprogramming is essential for maintaining energy homeostasis and supporting biosynthesis. A synergistic and precisely regulated metabolic network provides the necessary energy, reducing equivalents, and biosynthetic precursors for oocyte maturation, fertilization, and early embryonic development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This paper systematically reviews the key roles and regulatory mechanisms of the three major metabolic pathways in oocyte development. A literature\u2013based synthesis was conducted, integrating findings from studies on oocyte metabolism and metabolic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results show that metabolic dysregulation\u2014associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and early-onset ovarian insufficiency\u2014impairs oocyte quality and embryonic development potential by disrupting ovarian microenvironmental homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Furthermore, this review discusses potential strategies to increase the success rate of assisted reproduction, including targeted metabolic intervention, multi\u2013omics integration analysis, and mitochondrial function optimization, thereby providing a theoretical basis for clinical practice and scientific research in reproductive medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frph.2026.1803167","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:45:49Z","timestamp":1779342349000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of metabolic reprogramming in oocyte development: research progress and prospects"],"prefix":"10.3389","volume":"8","author":[{"given":"Yawen","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine, Wuhan University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Hubei Maternal and Child Health Hospital","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Hubei Maternal and Child Health Hospital","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science (New York, N.Y.)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"13666","DOI":"10.3390\/ijms222413666","article-title":"Glycolysis under circadian control","volume":"22","author":"Zlacka","year":"2021","journal-title":"Int J Mol 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