{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:04:49Z","timestamp":1789538689716,"version":"build-2803163510"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Reprod. Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Menopause-related symptoms are common but undertreated. Digital tools that support symptom assessment and patient education may improve engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether a previsit digital menopause symptom assessment and education tool increased treatment initiation and patient engagement compared to an educational pamphlet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Women aged 45\u201355 years with upcoming primary care appointments were invited to participate. Those with a total Menopause Rating Scale (MRS) score \u22655 indicating bothersome menopause symptoms were included. Participants were randomized to a digital menopause symptom assessment tool or a digital educational pamphlet and completed a post-visit survey (NCT06919887).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Of the 14,726 women invited to participate between May 12, 2025, and December 5, 2025, there were 653 (4.4%) enrolled that met eligibility criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Randomized to an mHealth app called emmii or a standard digital menopause educational pamphlet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main measures<\/jats:title>\n                    <jats:p>Menopause treatment initiation within 30 days of the clinical visit was assessed by electronic health data. Baseline and post-visit surveys were collected assessing patient experience, engagement, and perceived usefulness. Rates of menopause hormone therapy (HT) prescribing were compared with a reference population of nonparticipants aged 45\u201355 who had a primary care appointment at Mayo Clinic during the same period and received no study education materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>\n                      Of 653 participants enrolled and randomized, 383 completed both the baseline and post-surveys (171 intervention and 212 control). HT initiation among study participants was significantly higher than in the reference population of women (9.3% vs. 4.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). There was no difference in HT initiation between the intervention (9.1%) and control groups (9.6%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.83). Initiation rates were 3.8% and 4.5%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.64) for nonhormone therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among women with bothersome menopause symptoms, those who underwent previsit symptom screening and received educational materials had higher rates of HT initiation than women who did not participate in the study. These findings suggest that structured menopause education may improve recognition and management of menopause symptoms in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frph.2026.1952673","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:32:02Z","timestamp":1789536722000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A mobile app compared with an educational pamphlet on menopause hormone therapy initiation: a randomized pilot study"],"prefix":"10.3389","volume":"8","author":[{"given":"Juliana M.","family":"Kling","sequence":"first","affiliation":[{"name":"Division of Women\u2019s Health Internal Medicine, Mayo Clinic","place":["Scottsdale, AZ, United States"]},{"name":"Mayo Clinic Center for Women\u2019s Health, Mayo Clinic","place":["Rochester, MN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney A.","family":"French","sequence":"additional","affiliation":[{"name":"University of Notre Dame","place":["South Bend, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Mayo Clinic Center for Women\u2019s Health, Mayo Clinic","place":["Rochester, MN, United States"]},{"name":"Women\u2019s Health Research Center, Mayo Clinic","place":["Rochester, MN, United States"]},{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic","place":["Rochester, MN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Hedges","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Community Internal Medicine","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Paul","sequence":"additional","affiliation":[{"name":"Robert D. and Patricia E. 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