{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:10:50Z","timestamp":1792602650705,"version":"4.5.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Sleep"],"abstract":"<jats:sec><jats:title>Background\/objective<\/jats:title><jats:p>The serotoninergic nervous system is known to play a role in the maintenance of rapid eye movement (REM) sleep. Serotoninergic projections are known to be vulnerable in synucleinopathies. To date, positron emission tomography (PET) studies using serotonin-specific tracers have not been reported in isolated REM sleep behavior disorder (iRBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross-sectional imaging study using serotonin transporter (SERT) <jats:sup>11<\/jats:sup>C-3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile (DASB) PET to identify differences in serotonin system integrity between 11 participants with iRBD and 16 older healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with iRBD showed lower DASB distribution volume ratios (DVRs) in the total neocortical mantle [1.13 (SD: 0.07) vs. 1.19 (SD: 0.06); <jats:italic>t<\/jats:italic> = 2.33, <jats:italic>p<\/jats:italic> = 0.028)], putamen [2.07 (SD: 0.19) vs. 2.25 (SD: 0.18); <jats:italic>t<\/jats:italic> = 2.55, <jats:italic>p<\/jats:italic> = 0.017], and insula [1.26 (SD: 0.11) vs. 1.39 (SD: 0.09); <jats:italic>t<\/jats:italic> = 3.58, <jats:italic>p<\/jats:italic> = 0.001]. Paradoxical increases relative to controls were seen in cerebellar hemispheres [0.98 (SD: 0.04) vs. 0.95 (SD: 0.02); <jats:italic>t<\/jats:italic> = 2.93, <jats:italic>p<\/jats:italic> = 0.007)]. No intergroup differences were seen in caudate, substantia nigra, or other brainstem regions with the exception of the dorsal mesencephalic raphe [3.08 (SD: 0.53) vs. 3.47 (SD: 0.48); <jats:italic>t<\/jats:italic> = 2.00, <jats:italic>p<\/jats:italic> = 0.056] that showed a non-significant trend toward lower values in iRBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insular, neocortical, and striatal serotoninergic terminal loss may be common in prodromal synucleinopathies before the onset of parkinsonism or dementia. Given our small sample size, these results should be interpreted as hypothesis-generating\/exploratory in nature.<\/jats:p><\/jats:sec>","DOI":"10.3389\/frsle.2023.1298854","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T09:51:22Z","timestamp":1706521882000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Serotonin transporter density in isolated rapid eye movement sleep behavioral disorder"],"prefix":"10.3389","volume":"2","author":[{"given":"Mark","family":"Garwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punithavathy","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas I.","family":"Bohnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kotagal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-21","article-title":"Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness","author":"Albert","year":"2011","journal-title":"Mol. 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