{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:48:45Z","timestamp":1792273725758,"version":"4.4.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Sleep"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Professional palliative care for patients with cancer focuses on symptom management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This exploratory, randomized controlled study was conducted to compare the effects of complete home-based heart rate variability biofeedback (HRV-BFB) using an estimation formula for resonance frequency in managing insomnia disorders among patients with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 28 patients were included from the initial enrollment of 30 patients from two study sites. Results showed that compared to the control group, the HRV-BFB group improved sleep efficiency from 82.0% (standard deviation: 9.1%) to 87.8% (standard deviation: 7.2%) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) and decreased use of sleeping medication from 88.2% (95% confidence interval, 73.6\u201395.8) to 51.5% (95% confidence interval, 41.8\u201361.1) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This suggests that complete home-based HRV-BFB using an estimation formula for resonance frequency may be a promising tool for treating insomnia disorders in patients with cancer, potentially improving sleep efficiency and decreasing reliance on sleep medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>UMIN 000046884. Registered February 11, 2022. <jats:ext-link>https:\/\/center6.umin.ac.jp\/cgi-open-bin\/ctr\/ctr_view.cgi?recptno=R000053496<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/frsle.2025.1510293","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T09:36:50Z","timestamp":1742809010000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of complete home-based biofeedback therapy on insomnia disorders in patients with cancer"],"prefix":"10.3389","volume":"4","author":[{"given":"Hideaki","family":"Hasuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Shimazu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaharu","family":"Shizuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/S0921-884X(96)96070-1","article-title":"Heart rate variability: sleep stage, time of night, and arousal influences","volume":"102","author":"Bonnet","year":"1997","journal-title":"Electroencephalogr. 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