{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:50:42Z","timestamp":1770900642094,"version":"3.50.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Transplant."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Donor liver transaminases (ALT and AST) have been used to decline livers for transplant, despite evidence that they do not influence transplant outcomes. This study assesses the effect that raised donor transaminases have on the unnecessary decline of livers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study used the National Health Service registry on adult liver transplantation (2016\u20132019). Logistic regression models were built to assess the impact of donor transaminases on the utilisation of organs donated following brain stem death (DBD) and circulatory death (DCD). A further model was used to simulate the impact on liver decline if raised donor ALT was not used to make utilisation decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>5,424 adult livers were offered for transplant, of which 3,605 were utilised (2,841 DBD, 764 DCD). In multivariable analysis, adjusted for key factors, increasing peak donor ALT independently increased the odds of liver decline (DBD aOR\u2009=\u20091.396, 1.305\u20131.494, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001, DCD aOR\u2009=\u20091.162, 1.084\u20131.246, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). AST was also a significant predictor of liver decline. 18.5% of livers from DBD donors with ALT\u2009&amp;gt;\u200940\u2005U\/L (<jats:italic>n<\/jats:italic>\u2009=\u20091,683) were declined for transplantation. In this group, our model predicted a 48% (38%\u201358%) decrease in decline if raised donor ALT was excluded from these decisions. This represents an additional 37 (30\u201345) liver transplants every year in the UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Raised donor ALT increased the likelihood of liver decline. As it does not influence transplant outcome, avoiding donor ALT-based organ decline is an immediate and effective way to expand the donor pool.<\/jats:p><\/jats:sec>","DOI":"10.3389\/frtra.2024.1458996","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:14:41Z","timestamp":1725426881000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of donor transaminases on liver transplant utilisation and unnecessary organ discard: national registry cohort study"],"prefix":"10.3389","volume":"3","author":[{"given":"Joseph J.","family":"Dobbins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J.","family":"Tingle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Mehew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Kourounis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve A.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin H.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"B1","article-title":"Liver Transplantation Annual Report","year":"2022"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1097\/TP.0000000000004610","article-title":"Donor liver blood tests and liver transplant outcomes: UK registry cohort study","volume":"107","author":"Tingle","year":"2023","journal-title":"Transplantation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/ajt.15573","article-title":"Trends in deceased donor liver enzymes prior to transplant: the impact on graft selection and outcomes","volume":"20","author":"Kaltenbach","year":"2020","journal-title":"Am J Transplant"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e40140","DOI":"10.5812\/hepatmon.40140","article-title":"Transplantation of deceased donor livers with elevated levels of Serum transaminases at shiraz transplant center","volume":"16","author":"Fakhar","year":"2016","journal-title":"Hepat Mon"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/j.1478-3231.2011.02525.x","article-title":"Liver transplantation using donor organs with markedly elevated liver enzymes: how far can we go?","volume":"31","author":"Radunz","year":"2011","journal-title":"Liver Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1002\/sim.6986","article-title":"Quantifying the impact of different approaches for handling continuous predictors on the performance of a prognostic model","volume":"35","author":"Collins","year":"2016","journal-title":"Stat Med"},{"key":"B7","article-title":"Eurotransplant Organ Match Characteristics","year":""},{"key":"B8","doi-asserted-by":"publisher","first-page":"10460","DOI":"10.3389\/ti.2022.10460","article-title":"Normothermic machine perfusion-improving the supply of transplantable livers for high-risk recipients","volume":"35","author":"Hann","year":"2022","journal-title":"Transpl Int"},{"key":"B9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jhep.2015.10.006","article-title":"EASL clinical practice guidelines: liver transplantation","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cld.2016.12.004","article-title":"Extended criteria donors in liver transplantation","volume":"21","author":"Vodkin","year":"2017","journal-title":"Clin Liver Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1097\/TP.0000000000003945","article-title":"Transplantation of extended criteria donor livers following continuous normothermic machine perfusion without recooling","volume":"106","author":"Chen","year":"2022","journal-title":"Transplantation"},{"key":"B12","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/SLA.0000000000005110","article-title":"Hypothermic oxygenated machine perfusion reduces early allograft injury and improves post-transplant outcomes in extended criteria donation liver transplantation from donation after brain death: results from a multicenter randomized controlled trial (HOPE ECD-DBD)","volume":"274","author":"Czigany","year":"2021","journal-title":"Ann Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41586-018-0047-9","article-title":"A randomized trial of normothermic preservation in liver transplantation","volume":"557","author":"Nasralla","year":"2018","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.3390\/medicina58101434","article-title":"Viability criteria during liver ex-situ normothermic and hypothermic perfusion","volume":"58","author":"Melandro","year":"2022","journal-title":"Medicina (Kaunas)"}],"container-title":["Frontiers in Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frtra.2024.1458996\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:47:15Z","timestamp":1727185635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frtra.2024.1458996\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":14,"alternative-id":["10.3389\/frtra.2024.1458996"],"URL":"https:\/\/doi.org\/10.3389\/frtra.2024.1458996","relation":{},"ISSN":["2813-2440"],"issn-type":[{"value":"2813-2440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"article-number":"1458996"}}