{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:34:04Z","timestamp":1793644444980,"version":"4.5.1"},"reference-count":238,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Transplant."],"abstract":"<jats:p>\n                    The liver's extraordinary regenerative capacity has fascinated biologists for decades, yet the translation of regenerative biology into clinically effective therapies remains limited. Regeneration is not a simple proliferative response but a tightly orchestrated program initiated by tissue injury and coordinated through inflammatory priming, complement activation, mechanosensory signaling, extracellular matrix remodeling, metabolic reprogramming, and growth factor\u2013driven hepatocyte proliferation. In this review, we synthesize current understanding of the cellular and molecular networks that govern liver regeneration, emphasizing the dynamic crosstalk among hepatocytes, Kupffer cells, liver sinusoidal endothelial cells, hepatic stellate cells, and recruited immune populations. We further examine the major experimental systems used to study regeneration, from classic\n                    <jats:italic>in vivo<\/jats:italic>\n                    hepatectomy models to emerging human-relevant platforms, including organoids, liver-on-a-chip systems, extracellular matrix scaffolds, precision-cut liver slices, and\n                    <jats:italic>ex vivo<\/jats:italic>\n                    perfusion, highlighting both their mechanistic value and translational limitations. We then focus on the growing clinical importance of regeneration in transplantation, where the expanding use of marginal, steatotic, aged, and reduced-size grafts has intensified the need to preserve regenerative competence. In this context,\n                    <jats:italic>ex vivo<\/jats:italic>\n                    machine perfusion offers a uniquely promising platform to study, modulate, and therapeutically prime regenerative pathways before implantation, potentially enabling graft reconditioning strategies that improve outcomes in small-for-size and other high-risk liver grafts.\n                  <\/jats:p>","DOI":"10.3389\/frtra.2026.1841091","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:47:32Z","timestamp":1782280052000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic priming of liver regeneration: from mechanisms to ex vivo machine perfusion"],"prefix":"10.3389","volume":"5","author":[{"given":"Sarah Yoshimi","family":"Tropp","sequence":"first","affiliation":[{"name":"Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]},{"name":"Department of Surgery, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Jaishankar","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]},{"name":"Department of Surgery, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]},{"name":"Department of Surgery, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish N.","family":"Nadig","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]},{"name":"Department of Surgery, Feinberg School of Medicine, Northwestern University","place":["Chicago, IL, United States"]},{"name":"Department of Microbiology and Immunology and Pediatrics, Northwestern University","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr Biol"},{"key":"B2","first-page":"186","article-title":"Experimental pathology of the liver, restoration of the liver of the white rat following surgical removal","volume":"12","author":"Higgins","year":"1931","journal-title":"Arch Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1097\/TP.0000000000001411","article-title":"Innate immune regulations and liver ischemia-reperfusion injury","volume":"100","author":"Lu","year":"2016","journal-title":"Transplantation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3892\/ijmm.2021.4999","article-title":"Role of the S100 protein family in liver disease (review)","volume":"48","author":"Yao","year":"2021","journal-title":"Int J Mol Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1084\/jem.20070247","article-title":"HMGB1 Release induced by liver ischemia involves toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling","volume":"204","author":"Tsung","year":"2007","journal-title":"J Exp Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1084\/jem.20042614","article-title":"The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion","volume":"201","author":"Tsung","year":"2005","journal-title":"J Exp Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6965","DOI":"10.3748\/wjg.v22.i31.6965","article-title":"Mitochondrial DNA from hepatocytes as a ligand for TLR9: drivers of nonalcoholic steatohepatitis?","volume":"22","author":"Handa","year":"2016","journal-title":"World J Gastroenterol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e18715303401342","DOI":"10.2174\/0118715303401342250514102731","article-title":"Sterile inflammation and cell death pathways in liver ischemia-reperfusion injury: a review and perspective","volume":"26","author":"Huang","year":"2025","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"B10","doi-asserted-by":"publisher","first-page":"G1570","DOI":"10.1152\/ajpgi.00399.2006","article-title":"Loss of NF-kappaB activation in kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy","volume":"292","author":"Abshagen","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1053\/jhep.2003.50318","article-title":"Massive liver growth in mice induced by systemic interleukin 6 administration","volume":"38","author":"Zimmers","year":"2003","journal-title":"Hepatology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1073\/pnas.94.4.1441","article-title":"Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor","volume":"94","author":"Yamada","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice","volume":"274","author":"Cressman","year":"1996","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1007\/s10753-019-01078-y","article-title":"Characteristics of changes in inflammatory cytokines as a function of hepatic ischemia-reperfusion injury stage in mice","volume":"42","author":"Li","year":"2019","journal-title":"Inflammation"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.4049\/jimmunol.176.4.2522","article-title":"Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4","volume":"176","author":"Campbell","year":"2006","journal-title":"J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"G579","DOI":"10.1152\/ajpgi.1992.263.4.G579","article-title":"Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy","volume":"263","author":"Akerman","year":"1992","journal-title":"Am J Physiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"11281","DOI":"10.1074\/jbc.M208470200","article-title":"Interleukin-6\/glycoprotein 130-dependent pathways are protective during liver regeneration","volume":"278","author":"Wuestefeld","year":"2003","journal-title":"J Biol Chem"},{"key":"B18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1084\/jem.20070820","article-title":"Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3","volume":"205","author":"Riehle","year":"2008","journal-title":"J Exp Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1002\/hep.26197","article-title":"A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6\/STAT3 proliferative signals","volume":"57","author":"da Silva","year":"2013","journal-title":"Hepatology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.4049\/jimmunol.0804179","article-title":"The regulation of liver cell survival by complement","volume":"182","author":"Markiewski","year":"2009","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1084\/jem.20030374","article-title":"The proinflammatory mediators C3a and C5a are essential for liver regeneration","volume":"198","author":"Strey","year":"2003","journal-title":"J Exp Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.4049\/jimmunol.173.5.3418","article-title":"Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in Rat1","volume":"173","author":"Daveau","year":"2004","journal-title":"J Immunology"},{"key":"B23","first-page":"333","article-title":"The complement system in liver diseases","volume":"3","author":"Qin","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jhep.2004.02.017","article-title":"Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats","volume":"40","author":"Arumugam","year":"2004","journal-title":"J Hepatol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1084\/jem.20131902","article-title":"Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy","volume":"211","author":"Marshall","year":"2014","journal-title":"J Exp Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1172\/JCI38289","article-title":"A complement-dependent balance between hepatic ischemia\/reperfusion injury and liver regeneration in mice","volume":"119","author":"He","year":"2009","journal-title":"J Clin Invest"},{"key":"B27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fbioe.2023.1165651","article-title":"Biomechanics in liver regeneration after partial hepatectomy","volume":"11","author":"Wu","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00423-012-0913-0","article-title":"A critical appraisal of the hemodynamic signal driving liver regeneration","volume":"397","author":"Abshagen","year":"2012","journal-title":"Langenbecks Arch Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/208392a0","article-title":"Role of portal blood supply in liver regeneration","volume":"208","author":"Thomson","year":"1965","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1152\/physrev.00027.2008","article-title":"The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair","volume":"89","author":"Vollmar","year":"2009","journal-title":"Physiol Rev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11302-014-9442-3","article-title":"Shear stress modulates endothelial KLF2 through activation of P2X4","volume":"11","author":"Sathanoori","year":"2015","journal-title":"Purinergic Signal"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-5926-1-1","article-title":"Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review","volume":"1","author":"Braet","year":"2002","journal-title":"Comp Hepatol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e13131","DOI":"10.1111\/acel.13131","article-title":"Impaired integrin \u03b15\/\u03b21-mediated hepatocyte growth factor release by stellate cells of the aged liver","volume":"19","author":"Rohn","year":"2020","journal-title":"Aging Cell"},{"key":"B34","doi-asserted-by":"publisher","first-page":"46887","DOI":"10.1074\/jbc.M101865200","article-title":"Nitric oxide suppresses the expression of bcl-2 binding protein BNIP3 in hepatocytes","volume":"276","author":"Zamora","year":"2001","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jss.2006.07.027","article-title":"VEGF Is important for early liver regeneration after partial hepatectomy","volume":"138","author":"Bockhorn","year":"2007","journal-title":"J Surg Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature09493","article-title":"Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration","volume":"468","author":"Ding","year":"2010","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1476-5926-3-7","article-title":"Liver sinusoidal endothelial cell modulation upon resection and shear stress in vitro","volume":"3","author":"Braet","year":"2004","journal-title":"Comp Hepatol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10409-021-01057-3","article-title":"Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli","volume":"37","author":"Shu","year":"2021","journal-title":"Acta Mechanica Sinica"},{"key":"B39","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s42003-021-01936-2","article-title":"Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration","volume":"4","author":"Ishikawa","year":"2021","journal-title":"Commun Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e423","DOI":"10.1038\/emm.2017.205","article-title":"Hippo pathway coactivators yap and taz are required to coordinate mammalian liver regeneration","volume":"50","author":"Lu","year":"2018","journal-title":"Exp Mol Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/hep.510260415","article-title":"Extracellular matrix remodeling at the early stages of liver regeneration in the rat","volume":"26","author":"Kim","year":"1997","journal-title":"Hepatology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jss.2007.04.002","article-title":"A critical role for matrix metalloproteinases in liver regeneration","volume":"145","author":"Alwayn","year":"2008","journal-title":"J Surg Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/hep.23525","article-title":"Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice","volume":"51","author":"Ochoa","year":"2010","journal-title":"Hepatology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"G1093","DOI":"10.1152\/ajpgi.00292.2009","article-title":"Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis","volume":"297","author":"Choi","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1126\/science.1137603","article-title":"Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR","volume":"315","author":"Passino","year":"2007","journal-title":"Science"},{"key":"B46","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bbrc.2007.04.093","article-title":"Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway","volume":"358","author":"Tomiya","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"B47","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jhep.2007.07.032","article-title":"Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells","volume":"48","author":"Yang","year":"2008","journal-title":"J Hepatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"G1472","DOI":"10.1152\/ajpgi.1998.275.6.G1472","article-title":"Liver regeneration is transiently impaired in urokinase-deficient mice","volume":"275","author":"Roselli","year":"1998","journal-title":"Am J Physiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1002\/hep.1840210631","article-title":"Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration","volume":"21","author":"Mars","year":"1995","journal-title":"Hepatology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.22421","article-title":"Adenine nucleotide changes in the remnant liver: an early signal for regeneration after partial hepatectomy","volume":"48","author":"Crumm","year":"2008","journal-title":"Hepatology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.jcmgh.2022.07.011","article-title":"mTORC2 facilitates liver regeneration through sphingolipid-induced PPAR-\u03b1-fatty acid oxidation","volume":"14","author":"Zhang","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/hep.22473","article-title":"Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models","volume":"48","author":"Newberry","year":"2008","journal-title":"Hepatology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1186\/s12967-025-07232-5","article-title":"Lipid metabolism orchestrates liver regeneration: an integrated metabolic network","volume":"23","author":"Duan","year":"2025","journal-title":"J Transl Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.4254\/wjh.v12.i12.1198","article-title":"Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90% hepatectomy in the rat","volume":"12","author":"Moniaux","year":"2020","journal-title":"World J Hepatol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.devcel.2018.09.020","article-title":"Metabolic remodeling during liver regeneration","volume":"47","author":"Caldez","year":"2018","journal-title":"Dev Cell"},{"key":"B56","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cmet.2016.02.017","article-title":"AMPK Promotes autophagy by facilitating mitochondrial fission","volume":"23","author":"Zhang","year":"2016","journal-title":"Cell Metab"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7221","DOI":"10.3748\/wjg.v23.i40.7221","article-title":"Hypothermic machine perfusion with metformin-university of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model","volume":"23","author":"Chai","year":"2017","journal-title":"World J Gastroenterol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"108683","DOI":"10.1016\/j.isci.2023.108683","article-title":"Signaling pathways of liver regeneration: biological mechanisms and implications","volume":"27","author":"Zhang","year":"2024","journal-title":"iScience"},{"key":"B59","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev-pathol-030420-105050","article-title":"The hippo pathway in liver homeostasis and pathophysiology","volume":"16","author":"Driskill","year":"2021","journal-title":"Annu Rev Pathol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 Increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr Biol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12906-019-2536-2","article-title":"Panax notoginseng saponins promote liver regeneration through activation of the PI3\u2005K\/AKT\/mTOR cell proliferation pathway and upregulation of the AKT\/bad cell survival pathway in mice","volume":"19","author":"Zhong","year":"2019","journal-title":"BMC Complement Altern Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"102246","DOI":"10.1016\/j.redox.2022.102246","article-title":"Aquaporin-9 facilitates liver regeneration following hepatectomy","volume":"50","author":"Zhang","year":"2022","journal-title":"Redox Biol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"102034","DOI":"10.1016\/j.psj.2022.102034","article-title":"Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3\u2005K\/AKT\/Gsk3-beta pathway","volume":"101","author":"Cui","year":"2022","journal-title":"Poult Sci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"8806","DOI":"10.1074\/jbc.275.12.8806","article-title":"Cross-talk between epidermal growth factor receptor and c-met signal pathways in transformed cells","volume":"275","author":"Jo","year":"2000","journal-title":"J Biol Chem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1242\/dev.116.2.387","article-title":"The presence of hepatocyte growth factor in the developing rat","volume":"116","author":"Defrances","year":"1992","journal-title":"Development"},{"key":"B66","doi-asserted-by":"publisher","first-page":"808855","DOI":"10.3389\/fphar.2022.808855","article-title":"HGF\/c-Met: a key promoter in liver regeneration","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Pharmacol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1073\/pnas.80.12.3797","article-title":"Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system","volume":"80","author":"St Hilaire","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1002\/hep.28721","article-title":"Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation","volume":"64","author":"Paranjpe","year":"2016","journal-title":"Hepatology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2353\/ajpath.2010.090675","article-title":"Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas","volume":"176","author":"Michalopoulos","year":"2010","journal-title":"Am J Pathol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/S0142-9612(03)00508-8","article-title":"Animal models of liver regeneration","volume":"25","author":"Palmes","year":"2004","journal-title":"Biomaterials"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1053\/j.gastro.2013.09.009","article-title":"Mice with human livers","volume":"145","author":"Grompe","year":"2013","journal-title":"Gastroenterology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration\u2014mechanisms and models to clinical application","volume":"13","author":"Forbes","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1096\/fj.02-0494fje","article-title":"Mutation in collagen-I that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration","volume":"17","author":"Issa","year":"2003","journal-title":"FASEB J"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1073\/pnas.0610774104","article-title":"Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1","volume":"104","author":"Sadler","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B75","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.gde.2015.03.002","article-title":"The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration","volume":"32","author":"Cox","year":"2015","journal-title":"Curr Opin Genet Dev"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/j.2040-4603.2013.tb00516.x","article-title":"Zebrafish models of human liver development and disease","volume":"3","author":"Wilkins","year":"2013","journal-title":"Compr Physiol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ydbio.2008.05.526","article-title":"APC Mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development","volume":"320","author":"Goessling","year":"2008","journal-title":"Dev Biol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.ajpath.2018.03.008","article-title":"Understanding liver regeneration: from mechanisms to regenerative medicine","volume":"188","author":"Gilgenkrantz","year":"2018","journal-title":"Am J Pathol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ejps.2008.06.008","article-title":"Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human","volume":"35","author":"Li","year":"2008","journal-title":"Eur J Pharm Sci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1634\/stemcells.2007-0718","article-title":"Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo","volume":"26","author":"Hay","year":"2008","journal-title":"Stem Cells"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3727\/000000003783985179","article-title":"Generation of hepatocyte-like cells from human embryonic stem cells","volume":"12","author":"Rambhatla","year":"2003","journal-title":"Cell Transplant"},{"key":"B82","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1432-0436.2004.07205002.x","article-title":"Differentiation and isolation of hepatic-like cells from human embryonic stem cells","volume":"72","author":"Lavon","year":"2004","journal-title":"Differentiation"},{"key":"B83","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1089\/scd.2005.14.643","article-title":"Defined conditions for development of functional hepatic cells from human embryonic stem cells","volume":"14","author":"Schwartz","year":"2006","journal-title":"Stem Cells Dev"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e12544","DOI":"10.1111\/xen.12544","article-title":"Regenerative cell therapy for the treatment of hyperbilirubinemic gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells","volume":"27","author":"Fourrier","year":"2020","journal-title":"Xenotransplantation"},{"key":"B85","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.jhep.2014.10.016","article-title":"Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes","volume":"62","author":"Baxter","year":"2015","journal-title":"J Hepatol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/nature14863","article-title":"Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver","volume":"524","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"B87","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11626-008-9166-1","article-title":"Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells","volume":"45","author":"Krause","year":"2009","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"B88","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"B89","doi-asserted-by":"publisher","first-page":"8222","DOI":"10.1038\/s41598-018-26584-1","article-title":"Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system","volume":"8","author":"Garnier","year":"2018","journal-title":"Sci Rep"},{"key":"B90","doi-asserted-by":"publisher","first-page":"100533","DOI":"10.1016\/j.cobme.2024.100533","article-title":"Learning about liver regeneration from liver-on-a-chip","volume":"30","author":"Ortega-Ribera","year":"2024","journal-title":"Curr Opin Biomed Eng"},{"key":"B91","doi-asserted-by":"publisher","first-page":"025010","DOI":"10.1088\/1758-5090\/aaa97e","article-title":"Construction of a liver sinusoid based on the laminar flow on chip and self-assembly of endothelial cells","volume":"10","author":"Mi","year":"2018","journal-title":"Biofabrication"},{"key":"B92","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/hep.31106","article-title":"Liver-on-a-Chip models of fatty liver disease","volume":"71","author":"Hassan","year":"2020","journal-title":"Hepatology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"109393","DOI":"10.1016\/j.celrep.2021.109393","article-title":"Modeling alcohol-associated liver disease in a human liver-chip","volume":"36","author":"Nawroth","year":"2021","journal-title":"Cell Rep"},{"key":"B94","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s43856-022-00209-1","article-title":"Performance assessment and economic analysis of a human liver-chip for predictive toxicology","volume":"2","author":"Ewart","year":"2022","journal-title":"Commun Med (Lond)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"015003","DOI":"10.1088\/1758-5090\/aae543","article-title":"Optimization of collagen type I-hyaluronan hybrid bioink for 3D bioprinted liver microenvironments","volume":"11","author":"Mazzocchi","year":"2018","journal-title":"Biofabrication"},{"key":"B96","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nm.2170","article-title":"Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix","volume":"16","author":"Uygun","year":"2010","journal-title":"Nat Med"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.5966\/sctm.2015-0235","article-title":"Functional maturation of induced pluripotent stem cell hepatocytes in extracellular matrix-A comparative analysis of bioartificial liver microenvironments","volume":"5","author":"Wang","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1089\/ten.tea.2008.0587","article-title":"Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels","volume":"16","author":"Sellaro","year":"2009","journal-title":"Tissue Eng"},{"key":"B99","doi-asserted-by":"publisher","first-page":"27398","DOI":"10.1038\/srep27398","article-title":"The alterations in the extracellular matrix composition guide the repair of damaged liver tissue","volume":"6","author":"Klaas","year":"2016","journal-title":"Sci Rep"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1038\/s42003-024-07070-z","article-title":"Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production","volume":"7","author":"Kiyuna","year":"2024","journal-title":"Commun Biol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.tiv.2011.04.029","article-title":"Repair pathways evident in human liver organ slices","volume":"25","author":"Vickers","year":"2011","journal-title":"Toxicol in Vitro"},{"key":"B102","doi-asserted-by":"publisher","first-page":"14085","DOI":"10.1038\/s41598-017-14542-2","article-title":"In vivo and ex vivo methods of growing a liver bud through tissue connection","volume":"7","author":"Yanagi","year":"2017","journal-title":"Sci Rep"},{"key":"B103","doi-asserted-by":"publisher","first-page":"S211","DOI":"10.1097\/LVT.0000000000000775","article-title":"Liver transplant using the RAPID technique in a patient with colorectal liver metastases: case report of a first in the United States","volume":"25","author":"Dietch","year":"2025","journal-title":"Liver Transpl"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.4254\/wjh.v13.i11.1629","article-title":"Current strategies to induce liver remnant hypertrophy before major liver resection","volume":"13","author":"Del Basso","year":"2021","journal-title":"World J Hepatol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3978\/j.issn.2078-6891.2012.006","article-title":"Techniques of hepatic resection","volume":"3","author":"Aragon","year":"2012","journal-title":"J Gastrointest Oncol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"107378","DOI":"10.4254\/wjh.v17.i7.107378","article-title":"Liver regeneration after partial hepatectomy: triggers and mechanisms","volume":"17","author":"Korchilava","year":"2025","journal-title":"World J Hepatol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/00000658-199103000-00008","article-title":"Human liver regeneration after major hepatectomy. A study of liver volume by computed tomography","volume":"213","author":"Chen","year":"1991","journal-title":"Ann Surg"},{"key":"B108","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/SLA.0b013e31815f6e5b","article-title":"Preoperative portal vein embolization for major liver resection: a meta-analysis","volume":"247","author":"Abulkhir","year":"2008","journal-title":"Ann Surg"},{"key":"B109","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/BF01655244","article-title":"Preoperative portal vein embolization for hepatocellular carcinoma","volume":"10","author":"Kinoshita","year":"1986","journal-title":"World J Surg"},{"key":"B110","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1872-034X.2009.00599.x","article-title":"Serum HGF and TGF-beta1 levels after right portal vein embolization","volume":"40","author":"Hayashi","year":"2010","journal-title":"Hepatol Res"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1007\/s10620-006-9105-5","article-title":"Expression of transforming growth factor-alpha and -beta in hepatic lobes after hemihepatic portal vein embolization","volume":"51","author":"Kusaka","year":"2006","journal-title":"Dig Dis Sci"},{"key":"B112","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.jhep.2008.01.034","article-title":"Liver regeneration and recanalization time course following reversible portal vein embolization","volume":"49","author":"Lainas","year":"2008","journal-title":"J Hepatol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"37","DOI":"10.21037\/tgh.2019.12.01","article-title":"Associated liver partition and portal vein ligation for staged hepatectomy: a review","volume":"5","author":"Chan","year":"2020","journal-title":"Transl Gastroenterol Hepatol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.surg.2015.12.004","article-title":"Histologic features after surgery associating liver partition and portal vein ligation for staged hepatectomy versus those after hepatectomy with portal vein embolization","volume":"159","author":"Matsuo","year":"2016","journal-title":"Surgery"},{"key":"B115","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/SLA.0b013e31824856f5","article-title":"Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings","volume":"255","author":"Schnitzbauer","year":"2012","journal-title":"Ann Surg"},{"key":"B116","doi-asserted-by":"publisher","first-page":"270","DOI":"10.21037\/hbsn-21-7","article-title":"Liver venous deprivation: a bright future for liver metastases-but what about hepatocellular carcinoma?","volume":"10","author":"Guiu","year":"2021","journal-title":"Hepatobiliary Surg Nutr"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.3389\/fonc.2019.01206","article-title":"Exploration of the transcriptional landscape of ALPPS reveals the pathways of accelerated liver regeneration","volume":"9","author":"Borger","year":"2019","journal-title":"Front Oncol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.hpb.2016.01.547","article-title":"The many faces of ALPPS: surgical indications and techniques among surgeons collaborating in the international registry","volume":"18","author":"Buac","year":"2016","journal-title":"HPB (Oxford)"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21037\/hbsn.2019.10.36","article-title":"How should liver hypertrophy be stimulated? A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and portal vein embolization (PVE) with rescue possibility","volume":"10","author":"Sparrelid","year":"2021","journal-title":"Hepatobiliary Surg Nutr"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e3941","DOI":"10.1097\/MD.0000000000003941","article-title":"An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence","volume":"95","author":"Cai","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.ejso.2013.08.009","article-title":"Salvage parenchymal liver transection for patients with insufficient volume increase after portal vein occlusion\u2014an extension of the ALPPS approach","volume":"39","author":"Tschuor","year":"2013","journal-title":"European Journal of Surgical Oncology (EJSO"},{"key":"B122","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/00000658-200001000-00018","article-title":"Technical refinement in adult-to-adult living donor liver transplantation using right lobe graft","volume":"231","author":"Fan","year":"2000","journal-title":"Ann Surg"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1002\/lt.21622","article-title":"Liver regeneration in donors and adult recipients after living donor liver transplantation","volume":"14","author":"Haga","year":"2008","journal-title":"Liver Transpl"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1111\/ajt.12276","article-title":"Long-term outcomes of pediatric living donor liver transplantation in Japan: an analysis of more than 2200 cases listed in the registry of the Japanese liver transplantation society","volume":"13","author":"Kasahara","year":"2013","journal-title":"Am J Transplant"},{"key":"B125","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/lt.22288","article-title":"Outcomes of adult living donor liver transplantation: comparison of the adult-to-adult living donor liver transplantation cohort study and the national experience","volume":"17","author":"Olthoff","year":"2011","journal-title":"Liver Transpl"},{"key":"B126","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00007890-200301150-00018","article-title":"Factors influencing liver regeneration following living-donor liver transplantation of the right hepatic lobe","volume":"75","author":"Maetani","year":"2003","journal-title":"Transplantation"},{"key":"B127","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.hbpd.2019.01.006","article-title":"Middle hepatic vein reconstruction in adult right lobe living donor liver transplantation improves recipient survival","volume":"18","author":"Guo","year":"2019","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B128","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/BF01262776","article-title":"Transplantation einer spenderleber auf zwei empf\u00e4nger (splitting-transplantation) - eine neue methode in der weiterentwicklung der lebersegmenttransplantation","volume":"373","author":"Pichlmayr","year":"1988","journal-title":"Langenbecks Archiv f\u00fcr Chirurgie"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1046\/j.1600-6135.2003.00254.x","article-title":"Split-liver transplantation: a review","volume":"3","author":"Renz","year":"2003","journal-title":"Am J Transplant"},{"key":"B130","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/lt.25409","article-title":"Elevated risk of split-liver grafts in adult liver transplantation: statistical artifact or nature of the beast?","volume":"25","author":"Sasaki","year":"2019","journal-title":"Liver Transpl"},{"key":"B131","doi-asserted-by":"publisher","first-page":"8414","DOI":"10.3390\/ijms21218414","article-title":"Liver regeneration after hepatectomy and partial liver transplantation","volume":"21","author":"Yagi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B132","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/lt.25855","article-title":"A new approach for increasing availability of liver grafts and donor safety in living donor liver transplantation: lD-RAPID procedure in the cirrhotic setting with hepatocellular carcinoma","volume":"27","author":"Balci","year":"2021","journal-title":"Liver Transpl"},{"key":"B133","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/SLA.0000000000002861","article-title":"Paradigm shift in the management of irresectable colorectal liver metastases: living donor auxiliary partial orthotopic liver transplantation in combination with two-stage hepatectomy (LD-RAPID)","volume":"270","author":"Konigsrainer","year":"2019","journal-title":"Ann Surg"},{"key":"B134","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1097\/SLA.0000000000001165","article-title":"A novel concept for partial liver transplantation in nonresectable colorectal liver metastases: the RAPID concept","volume":"262","author":"Line","year":"2015","journal-title":"Ann Surg"},{"key":"B135","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijsu.2020.03.078","article-title":"RAPID Procedure for colorectal cancer liver metastasis","volume":"82","author":"Nadalin","year":"2020","journal-title":"Int J Surg"},{"key":"B136","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1186\/s12885-025-14127-7","article-title":"Resection and partial liver transplantation from deceased donors with delayed total hepatectomy (RAPID procedure) for hepatocellular carcinoma: a national, multicenter, non-randomized, prospective trial","volume":"25","author":"Peloso","year":"2025","journal-title":"BMC Cancer"},{"key":"B137","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/SLA.0000000000005726","article-title":"Auxilliary liver transplantation according to the RAPID procedure in noncirrhotic patients: technical aspects and early outcomes","volume":"277","author":"Settmacher","year":"2023","journal-title":"Ann Surg"},{"key":"B138","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0168-8278(02)00171-X","article-title":"Mechanical stress-dependent secretion of interleukin 6 by endothelial cells after portal vein embolization: clinical and experimental studies","volume":"37","author":"Kawai","year":"2002","journal-title":"J Hepatol"},{"key":"B139","first-page":"2065","article-title":"Methods to increase future liver remnant volume in patients with primarily unresectable colorectal liver metastases: current state and future perspectives","volume":"36","author":"Treska","year":"2016","journal-title":"Anticancer Res"},{"key":"B140","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1097\/00007890-200006150-00034","article-title":"Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation","volume":"69","author":"Marcos","year":"2000","journal-title":"Transplantation"},{"key":"B141","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/lt.24373","article-title":"Serial changes of cytokines and growth factors in peripheral circulation after right lobe donor hepatectomy","volume":"22","author":"Sasturkar","year":"2016","journal-title":"Liver Transpl"},{"key":"B142","doi-asserted-by":"publisher","first-page":"e0195262","DOI":"10.1371\/journal.pone.0195262","article-title":"Serum interleukin-6 and tumor necrosis factor-alpha are associated with early graft regeneration after living donor liver transplantation","volume":"13","author":"Chae","year":"2018","journal-title":"PLoS One"},{"key":"B143","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4285\/jkstn.2019.33.4.65","article-title":"Conceptual changes in small-for-size graft and small-for-size syndrome in living donor liver transplantation","volume":"33","author":"Ikegami","year":"2019","journal-title":"Korean J Transplant"},{"key":"B144","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.hbpd.2020.06.015","article-title":"Small-for-size syndrome in liver transplantation: definition, pathophysiology and management","volume":"19","author":"Masuda","year":"2020","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B145","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1097\/TP.0000000000004769","article-title":"Preventing small-for-size syndrome in living donor liver transplantation: guidelines from the ILTS-iLDLT-LTSI consensus conference","volume":"107","author":"Hakeem","year":"2023","journal-title":"Transplantation"},{"key":"B146","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/lt.20317","article-title":"Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation","volume":"11","author":"Yagi","year":"2005","journal-title":"Liver Transpl"},{"key":"B147","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/01.tp.0000198122.15235.a7","article-title":"Optimal portal venous circulation for liver graft function after living-donor liver transplantation","volume":"81","author":"Yagi","year":"2006","journal-title":"Transplantation"},{"key":"B148","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/liv.14091","article-title":"Ischaemia reperfusion injury in liver transplantation: cellular and molecular mechanisms","volume":"39","author":"Dar","year":"2019","journal-title":"Liver Int"},{"key":"B149","doi-asserted-by":"publisher","first-page":"381","DOI":"10.12659\/AOT.894082","article-title":"Liver volume restoration and hepatic microarchitecture in small-for-size syndrome","volume":"20","author":"Gruttadauria","year":"2015","journal-title":"Ann Transplant"},{"key":"B150","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41392-024-02104-8","article-title":"Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics","volume":"10","author":"Ma","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1002\/bjs.5820","article-title":"Steatosis predicts postoperative morbidity following hepatic resection for colorectal metastasis","volume":"94","author":"Gomez","year":"2007","journal-title":"Br J Surg"},{"key":"B152","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/liv.12089","article-title":"The impact of hepatic steatosis on liver regeneration after partial hepatectomy","volume":"33","author":"Kele","year":"2013","journal-title":"Liver Int"},{"key":"B153","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/S1499-3872(12)60227-6","article-title":"Small-for-size syndrome in living donor liver transplantation","volume":"11","author":"Yagi","year":"2012","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B154","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3390\/jcm9030846","article-title":"Ischemia-Reperfusion injury in marginal liver grafts and the role of hypothermic machine perfusion: molecular mechanisms and clinical implications","volume":"9","author":"Czigany","year":"2020","journal-title":"J Clin Med"},{"key":"B155","doi-asserted-by":"publisher","first-page":"221","DOI":"10.7555\/JBR.32.20180087","article-title":"Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies","volume":"33","author":"Rampes","year":"2019","journal-title":"J Biomed Res"},{"key":"B156","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/cld.222","article-title":"Expanding the donor pool in liver transplantation: extended criteria donors","volume":"2","author":"deLemos","year":"2013","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"B157","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/00007890-200202150-00001","article-title":"Hepatic steatosis and liver transplantation current clinical and experimental perspectives","volume":"73","author":"Koneru","year":"2002","journal-title":"Transplantation"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1038\/s41598-020-58714-z","article-title":"Risk factors of silent allograft fibrosis 10 years post-pediatric liver transplantation","volume":"10","author":"Rhu","year":"2020","journal-title":"Sci Rep"},{"key":"B159","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/lt.26335","article-title":"Use of livers with fibrosis based on donor hospital biopsy: missed opportunities?","volume":"28","author":"Narasimman","year":"2022","journal-title":"Liver Transpl"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1547200","DOI":"10.3389\/fmed.2025.1547200","article-title":"The impact of donor liver fibrosis on the outcomes of patients who undergo liver transplant: a cohort study from UNOS database","volume":"12","author":"Bian","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"B161","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.trim.2014.06.008","article-title":"Accelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts","volume":"31","author":"Aini","year":"2014","journal-title":"Transpl Immunol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat Med"},{"key":"B163","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ajt.2023.10.013","article-title":"Transplanting old organs promotes senescence in young recipients","volume":"24","author":"Iske","year":"2024","journal-title":"Am J Transplant"},{"key":"B164","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"B165","doi-asserted-by":"publisher","first-page":"817","DOI":"10.17179\/excli2016-800","article-title":"The past and present of serum aminotransferases and the future of liver injury biomarkers","volume":"15","author":"McGill","year":"2016","journal-title":"EXCLI J"},{"key":"B166","doi-asserted-by":"publisher","first-page":"100722","DOI":"10.1016\/j.jhepr.2023.100722","article-title":"Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension","volume":"5","author":"Ortega-Ribera","year":"2023","journal-title":"JHEP Rep"},{"key":"B167","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jhep.2014.04.031","article-title":"Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation","volume":"61","author":"Verhoeven","year":"2014","journal-title":"J Hepatol"},{"key":"B168","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/01.sla.0000234896.18207.fa","article-title":"Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival","volume":"244","author":"Tector","year":"2006","journal-title":"Ann Surg"},{"key":"B169","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.transproceed.2009.02.016","article-title":"Extended criteria donors in liver transplantation: adapting donor quality and recipient","volume":"41","author":"Gastaca","year":"2009","journal-title":"Transplant Proc"},{"key":"B170","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41419-021-03878-3","article-title":"Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis"},{"key":"B171","doi-asserted-by":"publisher","first-page":"386","DOI":"10.21037\/hbsn.2018.06.08","article-title":"Extended criteria donors in liver transplantation-from marginality to mainstream","volume":"7","author":"Nair","year":"2018","journal-title":"Hepatobiliary Surg Nutr"},{"key":"B172","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/00000658-198707000-00005","article-title":"Human liver regeneration after major hepatic resection. A study of normal liver and livers with chronic hepatitis and cirrhosis","volume":"206","author":"Nagasue","year":"1987","journal-title":"Ann Surg"},{"key":"B173","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"497","DOI":"10.6002\/ect.2024.0137","article-title":"Liver graft machine perfusion: from history perspective to modern approaches in transplant surgery","volume":"22","author":"Semash","year":"2024","journal-title":"Exp Clin Transplant"},{"key":"B175","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jceh.2022.08.001","article-title":"A review of machine perfusion strategies in liver transplantation","volume":"13","author":"Banker","year":"2023","journal-title":"J Clin Exp Hepatol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1097\/TP.0000000000002772","article-title":"Ex situ liver machine perfusion as an emerging graft protective strategy in clinical liver transplantation: the Dawn of a new era","volume":"103","author":"Nickkholgh","year":"2019","journal-title":"Transplantation"},{"key":"B177","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/lt.25007","article-title":"Ex situ 86-hour liver perfusion: pushing the boundary of organ preservation","volume":"24","author":"Liu","year":"2018","journal-title":"Liver Transpl"},{"key":"B178","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.eng.2023.11.003","article-title":"Machine perfusion plus for extended criteria donor liver grafts: making every liver count","volume":"32","author":"Wang","year":"2024","journal-title":"Engineering"},{"key":"B179","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fmed.2020.00135","article-title":"A systematic review and meta-analysis of machine perfusion vs","volume":"7","author":"Jia","year":"2020","journal-title":"Static Cold Storage of Liver Allografts on Liver Transplantation Outcomes: the Future Direction of Graft Preservation. Frontiers in Medicine"},{"key":"B180","doi-asserted-by":"publisher","first-page":"e1726","DOI":"10.1097\/TXD.0000000000001726","article-title":"Use of machine perfusion in the United States increases organ utilization and improves DCD graft survival in liver transplantation","volume":"10","author":"Wisel","year":"2024","journal-title":"Liver Transpl"},{"key":"B181","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1159\/000104250","article-title":"Hypothermic blood substitution: special considerations for protection of cells during ex vivo and in vivo preservation","volume":"34","author":"Taylor","year":"2007","journal-title":"Transfus Med Hemother"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.3390\/life15071112","article-title":"Hypothermic machine perfusion is associated with improved short-term outcomes in liver transplantation: a retrospective cohort study","volume":"15","author":"Nastase","year":"2025","journal-title":"Life (Basel)"},{"key":"B183","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.transproceed.2004.12.069","article-title":"Hepatic function in hypothermically stored porcine livers: comparison of hypothermic machine perfusion vs cold storage","volume":"37","author":"Jain","year":"2005","journal-title":"Transplant Proc"},{"key":"B184","doi-asserted-by":"publisher","first-page":"e741","DOI":"10.1097\/TXD.0000000000001184","article-title":"Dual versus single oxygenated hypothermic machine perfusion of porcine livers: impact on hepatobiliary and endothelial cell injury","volume":"7","author":"de Vries","year":"2021","journal-title":"Transplant Direct"},{"key":"B185","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/SLA.0000000000003513","article-title":"Novel real-time prediction of liver graft function during hypothermic oxygenated machine perfusion before liver transplantation","volume":"270","author":"Muller","year":"2019","journal-title":"Ann Surg"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1056\/NEJMoa2031532","article-title":"Hypothermic machine perfusion in liver transplantation \u2014 a randomized trial","volume":"384","author":"Rv","year":"2021","journal-title":"N Engl J Med"},{"key":"B187","doi-asserted-by":"publisher","first-page":"993","DOI":"10.3390\/biomedicines9080993","article-title":"Simply adding oxygen during hypothermic machine perfusion to combat the negative effects of ischemia-reperfusion injury: fundamentals and current evidence for kidneys","volume":"9","author":"Darius","year":"2021","journal-title":"Biomedicines"},{"key":"B188","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s40472-018-0183-z","article-title":"Hypothermic machine preservation of the liver: state of the art","volume":"5","author":"Schlegel","year":"2018","journal-title":"Curr Transplant Rep"},{"key":"B189","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3109\/08941939009140356","article-title":"Ex vivo perfusion for accurate assessment of liver graft viability in dogs","volume":"3","author":"Fukuzawa","year":"1990","journal-title":"J Invest Surg"},{"key":"B190","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1038\/s41467-020-16251-3","article-title":"Transplantation of discarded livers following viability testing with normothermic machine perfusion","volume":"11","author":"Mergental","year":"2020","journal-title":"Nat Commun"},{"key":"B191","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1001\/jamasurg.2021.6781","article-title":"Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver PROTECT randomized clinical trial","volume":"157","author":"Markmann","year":"2022","journal-title":"JAMA Surg"},{"key":"B192","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41586-018-0047-9","article-title":"A randomized trial of normothermic preservation in liver transplantation","volume":"557","author":"Nasralla","year":"2018","journal-title":"Nature"},{"key":"B193","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1055\/s-0040-1713118","article-title":"Machine perfusion: cold versus warm, versus neither. Update on clinical trials","volume":"40","author":"Bonaccorsi-Riani","year":"2020","journal-title":"Semin Liver Dis"},{"key":"B194","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s41587-019-0374-x","article-title":"An integrated perfusion machine preserves injured human livers for 1 week","volume":"38","author":"Eshmuminov","year":"2020","journal-title":"Nat Biotechnol"},{"key":"B195","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.1038\/s41467-023-40154-8","article-title":"Long-term ex situ normothermic perfusion of human split livers for more than 1 week","volume":"14","author":"Lau","year":"2023","journal-title":"Nat Commun"},{"key":"B196","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/lt.24453","article-title":"Protective role of normothermic machine perfusion during reduced-size liver transplantation in pigs","volume":"22","author":"Zhang","year":"2016","journal-title":"Liver Transpl"},{"key":"B197","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/s41587-022-01354-7","article-title":"Transplantation of a human liver following 3 days of ex situ normothermic preservation","volume":"40","author":"Clavien","year":"2022","journal-title":"Nat Biotechnol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"e0188494","DOI":"10.1371\/journal.pone.0188494","article-title":"Successful transplantation of porcine liver grafts following 48-hour normothermic preservation","volume":"12","author":"Vogel","year":"2017","journal-title":"PLoS One"},{"key":"B199","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2047-1440-1-6","article-title":"A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation","volume":"1","author":"Berendsen","year":"2012","journal-title":"Transplant Res"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1111\/ajt.12727","article-title":"Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation","volume":"14","author":"Bruinsma","year":"2014","journal-title":"Am J Transplant"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1097\/TP.0000000000005301","article-title":"Outcomes of DCD liver transplant using sequential normothermic regional perfusion and normothermic machine perfusion or NRP alone versus static cold storage","volume":"109","author":"Croome","year":"2025","journal-title":"Transplantation"},{"key":"B202","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1111\/cts.13409","article-title":"Controlled oxygenated rewarming as novel end-ischemic therapy for cold stored liver grafts. A randomized controlled trial","volume":"15","author":"Minor","year":"2022","journal-title":"Clin Transl Sci"},{"key":"B203","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1097\/TP.0000000000003295","article-title":"Review of current machine perfusion therapeutics for organ preservation","volume":"104","author":"Xu","year":"2020","journal-title":"Transplantation"},{"key":"B204","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1053\/jlts.2003.50099","article-title":"Clinical experience gained from the use of 120 steatotic donor livers for orthotopic liver transplantation","volume":"9","author":"Verran","year":"2003","journal-title":"Liver Transpl"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.042663","article-title":"Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis","volume":"13","author":"Aoudjehane","year":"2020","journal-title":"Dis Model Mech"},{"key":"B206","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.ymben.2009.05.005","article-title":"Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo","volume":"11","author":"Nagrath","year":"2009","journal-title":"Metab Eng"},{"key":"B207","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/lt.25439","article-title":"Manipulation of lipid metabolism during normothermic machine perfusion: effect of defatting therapies on donor liver functional recovery","volume":"25","author":"Boteon","year":"2019","journal-title":"Liver Transpl"},{"key":"B208","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1016\/j.transproceed.2008.07.143","article-title":"Hepatic ischemia-reperfusion induces insulin resistance via down-regulation during the early steps in insulin signaling in rats","volume":"40","author":"Liu","year":"2008","journal-title":"Transplant Proc"},{"key":"B209","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.jhep.2022.04.033","article-title":"Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: what does the future have in store for US?","volume":"77","author":"Lascaris","year":"2022","journal-title":"J Hepatol"},{"key":"B210","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1101\/gad.332643.119","article-title":"The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice","volume":"34","author":"Ritschka","year":"2020","journal-title":"Genes Dev"},{"key":"B211","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1038\/s41467-020-18039-x","article-title":"Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation","volume":"11","author":"Iske","year":"2020","journal-title":"Nat Commun"},{"key":"B212","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1111\/aor.14939","article-title":"Perfusion pressures and weight loss during normothermic machine perfusion of human donor livers","volume":"49","author":"Lascaris","year":"2025","journal-title":"Artif Organs"},{"key":"B213","doi-asserted-by":"publisher","first-page":"G183","DOI":"10.1152\/ajpgi.00257.2021","article-title":"Long-term normothermic machine preservation of human livers: what is needed to succeed?","volume":"322","author":"Lascaris","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B214","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/HEP.0000000000000207","article-title":"The evolving role of liver sinusoidal endothelial cells in liver health and disease","volume":"78","author":"McConnell","year":"2023","journal-title":"Hepatology"},{"key":"B215","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jss.2019.04.010","article-title":"[D-Ala2, D-Leu5] enkephalin improves liver preservation during normothermic ex vivo perfusion","volume":"241","author":"Beal","year":"2019","journal-title":"J Surg Res"},{"key":"B216","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/hep.30508","article-title":"The role of complement in liver injury, regeneration, and transplantation","volume":"70","author":"Thorgersen","year":"2019","journal-title":"Hepatology"},{"key":"B217","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2013.03.026","article-title":"A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration","volume":"153","author":"Wuestefeld","year":"2013","journal-title":"Cell"},{"key":"B218","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/ajt.14100","article-title":"Inducing hepatitis C virus resistance after pig liver transplantation-A proof of concept of liver graft modification using warm ex vivo perfusion","volume":"17","author":"Goldaracena","year":"2017","journal-title":"Am J Transplant"},{"key":"B219","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1097\/TP.0000000000002515","article-title":"First report of siRNA uptake (for RNA interference) during ex vivo hypothermic and normothermic liver machine perfusion","volume":"103","author":"Gillooly","year":"2019","journal-title":"Transplantation"},{"key":"B220","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/lt.25383","article-title":"Gene silencing with siRNA (RNA interference): a new therapeutic option during ex vivo machine liver perfusion preservation","volume":"25","author":"Thijssen","year":"2019","journal-title":"Liver Transpl"},{"key":"B221","doi-asserted-by":"publisher","first-page":"e205","DOI":"10.1097\/TP.0000000000002123","article-title":"Extracellular vesicles from human liver stem cells reduce injury in an ex vivo normothermic hypoxic rat liver perfusion model","volume":"102","author":"Rigo","year":"2018","journal-title":"Transplantation"},{"key":"B222","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00441-020-03202-z","article-title":"Bone marrow mesenchymal stem cells combine with normothermic machine perfusion to improve rat donor liver quality-the important role of hepatic microcirculation in donation after circulatory death","volume":"381","author":"Yang","year":"2020","journal-title":"Cell Tissue Res"},{"key":"B223","doi-asserted-by":"publisher","first-page":"e930258","DOI":"10.12659\/MSM.930258","article-title":"Protective effects of bone marrow mesenchymal stem cells (BMMSCS) combined with normothermic machine perfusion on liver grafts donated after circulatory death via reducing the ferroptosis of hepatocytes","volume":"27","author":"Sun","year":"2021","journal-title":"Med Sci Monit"},{"key":"B224","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1089\/scd.2019.0301","article-title":"Normothermic machine perfusion combined with bone marrow mesenchymal stem cells improves the oxidative stress response and mitochondrial function in rat donation after circulatory death livers","volume":"29","author":"Yang","year":"2020","journal-title":"Stem Cells Dev"},{"key":"B225","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1097\/TP.0000000000002986","article-title":"First report on ex vivo delivery of paracrine active human mesenchymal stromal cells to liver grafts during machine perfusion","volume":"104","author":"Verstegen","year":"2020","journal-title":"Transplantation"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.3389\/fimmu.2020.01226","article-title":"The delivery of multipotent adult progenitor cells to extended criteria human donor livers using normothermic machine perfusion","volume":"11","author":"Laing","year":"2020","journal-title":"Front Immunol"},{"key":"B227","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1126\/science.818706","article-title":"Hepatocellular transplantation for metabolic deficiencies: decrease of plasma bilirubin in gunn rats","volume":"192","author":"Matas","year":"1976","journal-title":"Science"},{"key":"B228","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nrgastro.2010.44","article-title":"Human hepatocyte transplantation: current experience and future challenges","volume":"7","author":"Dhawan","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B229","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/stem.2500","article-title":"Concise review: liver regenerative medicine: from hepatocyte transplantation to bioartificial livers and bioengineered grafts","volume":"35","author":"Nicolas","year":"2017","journal-title":"Stem Cells"},{"key":"B230","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1097\/TP.0000000000002021","article-title":"Comparison of BQ123, epoprostenol, and verapamil as vasodilators during normothermic ex vivo liver machine perfusion","volume":"102","author":"Echeverri","year":"2018","journal-title":"Transplantation"},{"key":"B231","doi-asserted-by":"publisher","first-page":"e70011","DOI":"10.1111\/xen.70011","article-title":"Bridging therapies\u2014ex vivo liver Xenoperfusion and the role of machine perfusion: an update","volume":"32","author":"Czigany","year":"2025","journal-title":"Xenotransplantation"},{"key":"B232","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1051\/ject\/201143195","article-title":"Extracorporeal bioartificial liver for treating acute liver diseases","volume":"43","author":"Kumar","year":"2011","journal-title":"J Extra Corpor Technol"},{"key":"B233","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","article-title":"Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases","volume":"271","author":"Dueland","year":"2020","journal-title":"Ann Surg"},{"key":"B234","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/SLA.0b013e3182823957","article-title":"Liver transplantation for nonresectable liver metastases from colorectal cancer","volume":"257","author":"Hagness","year":"2013","journal-title":"Ann Surg"},{"key":"B235","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1097\/MOT.0000000000000695","article-title":"Auxiliary living donor liver transplantation combined with two-stage hepatectomy for unresectable colorectal liver metastases","volume":"24","author":"Nadalin","year":"2019","journal-title":"Curr Opin Organ Transplant"},{"key":"B236","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/SLA.0000000000006475","article-title":"In-depth clinical, hemodynamic, and volumetric assessment of the resection and partial liver transplantation with delayed total hepatectomy-type auxiliary liver transplantation in noncirrhotic setting: are we simply dealing with a transplant model of associating liver partition and portal vein ligation for staged hepatectomy?","volume":"280","author":"Coubeau","year":"2024","journal-title":"Ann Surg"},{"key":"B237","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/SLA.0b013e3182a64b38","article-title":"Posthepatectomy portal vein pressure predicts liver failure and mortality after major liver resection on noncirrhotic liver","volume":"258","author":"Allard","year":"2013","journal-title":"Ann Surg"},{"key":"B238","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1097\/js9.0000000000002145","article-title":"International consensus recommendations for the RAPID procedure in liver transplantation: the RAPID consensus ISLS 2023 Zurich collaborative","volume":"111","author":"Collaborative","year":"2025","journal-title":"Int J Surg"}],"container-title":["Frontiers in Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frtra.2026.1841091\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:47:38Z","timestamp":1782280058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frtra.2026.1841091\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":238,"alternative-id":["10.3389\/frtra.2026.1841091"],"URL":"https:\/\/doi.org\/10.3389\/frtra.2026.1841091","relation":{},"ISSN":["2813-2440"],"issn-type":[{"value":"2813-2440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"article-number":"1841091"}}