{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:31:55Z","timestamp":1786422715997,"version":"build-2736575974"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Transplant."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urinary tract infection (UTI) including extended-spectrum \u03b2-lactamase (ESBL)-producing organisms is a common early complication after kidney transplantation. Increasing prevalence of ESBL may adversely affect graft and patient outcomes. This study aimed to evaluate the incidence, timing, predictors, and outcomes of UTI, including ESBL infection, after kidney transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We retrospectively studied 1,804 adult kidney transplant recipients (2016\u20132024) at a tertiary center. UTIs were analyzed for incidence, timing, microbiology, and predictors using multivariable logistic regression. Outcomes included rejection, graft loss, and mortality. ESBL and non-ESBL UTIs were compared, and long-term outcomes assessed using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      UTI occurred in 693 recipients (38.4%) within the first year post-transplant with 57.4% occurring within 30 days and 84.2% within 90 days. UTIs were more common during ureteric stent indwelling than after removal (64.3% vs. 35.7%). Independent predictors included female sex, older age, deceased donor transplantation, pre-transplant UTI, and post-transplant urological complications. ESBL UTI were identified in 47.9% of patients and were associated with earlier infection, higher recurrence rates and occurred more frequently during stent indwelling (69.0% vs. 60.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). UTI was associated with higher rejection, graft loss, and mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.005). ESBL UTI further increased rejection and graft loss. In adjusted analyses, ESBL UTI independently associated with death-censored graft loss (aHR 2.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and mortality (aHR 2.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UTIs are common early after kidney transplantation, particularly during ureteric stent indwelling. ESBL infections are independently associated with adverse graft outcomes and mortality, supporting targeted surveillance, antimicrobial stewardship, and ureteric stent management optimization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frtra.2026.1902904","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:21:38Z","timestamp":1786422098000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early urinary tract infection after kidney transplantation: timing, stent association, extended-spectrum \u03b2-lactamase infections, and clinical outcomes in a large cohort"],"prefix":"10.3389","volume":"5","author":[{"given":"Rehab Salah Fathy","family":"Nasr","sequence":"first","affiliation":[{"name":"Kidney and Pancreas Health Centre, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]},{"name":"Department of Internal Medicine and Nephrology, Faculty of Medicine, Benha University","place":["Benha, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter Clemens","family":"Broering","sequence":"additional","affiliation":[{"name":"Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia Abdullah Ghalib","family":"Obeid","sequence":"additional","affiliation":[{"name":"Transplant Research and Innovation, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Almaghrabi","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Section, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas Mamdouh Mohamed Ali","family":"Hussein","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Health Centre, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]},{"name":"Department of Internal Medicine and Nephrology, Faculty of Medicine, Benha University","place":["Benha, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Nasser","family":"Teljabini","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Health Centre, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar Mohammed Saber","family":"Almadi","sequence":"additional","affiliation":[{"name":"Organ Transplant Service, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq Zulfiqar","family":"Ali","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Health Centre, King Faisal Specialist Hospital and Research Centre","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0251036","DOI":"10.1371\/journal.pone.0251036","article-title":"Incidence and risk factors for urinary tract infections in the first year after renal transplantation","volume":"16","author":"Velioglu","year":"2021","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.transproceed.2016.01.061","article-title":"Urinary tract infections in kidney transplant recipients hospitalized at a transplantation and nephrology ward: 1-year follow-up","volume":"48","author":"Gozdowska","year":"2016","journal-title":"Transplant 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