{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:45:15Z","timestamp":1774849515813,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Urol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Thulium fiber laser (TFL) technology, with its shorter wavelength and higher water absorption coefficient compared to Holmium: YAG laser, offers theoretical advantages in tissue ablation efficiency and safety profile. We aim to evaluate the early safety and feasibility of Thulium fiber laser enucleation of prostate (ThuFLEP) using the SOLTIVE\u2122 SuperPulsed Laser Systems in the first Asian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-two consecutive men underwent ThuFLEP between October 2022 and September 2025. The primary outcome was the rate of Clavien-Dindo grade \u22653 complications as a safety and feasibility signal, along with assessment of short-to-medium-term functional outcomes. Data are presented as median (interquartile range, IQR). Changes in PSA were analyzed using the Wilcoxon signed-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median prostate size was 60\u00a0ml (IQR 49.8\u201376.0 ml), with 50% of patients being catheter dependent. Median operation time was 87 minutes (IQR 73\u2013100 mins). Median enucleated adenoma weight was 31\u00a0g (IQR 20\u201339 g). No Clavien-Dindo grade \u22653 complications occurred. Catheter-free rate was 87.5% on day 1 and 100% by day 14. At 3-month follow-up, median IPSS was 4 (IQR 1\u20138), median Qmax was 21.5 ml\/s (IQR 12.9\u201328.4 ml\/s), with significant PSA reduction (from 6.05 to 1.20 ng\/ml; p&amp;lt;0.001). At 12 months (n=25), median Qmax was 21.9 ml\/s (IQR 15.2\u201326.8 ml\/s), median IPSS was 2 (IQR 1\u20135), and there was no surgical or medical retreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ThuFLEP demonstrates early safety and feasibility in this Asian cohort, including catheter-dependent patients. Larger, multicenter studies with longer follow-up are warranted to confirm its safety and efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , identifier NCT05292235.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fruro.2026.1753089","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:13:12Z","timestamp":1774843992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Thulium fiber laser enucleation of the prostate with SOLTIVE\u2122 SuperPulsed laser systems: a prospective evaluation of early outcomes in an Asian cohort"],"prefix":"10.3389","volume":"6","author":[{"given":"Brian W.H.","family":"Siu","sequence":"first","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.W.","family":"Leung","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel S.K.","family":"Wong","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris H.M.","family":"Wong","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex Q.","family":"Liu","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Hang","family":"Yee","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy Y.C.","family":"Teoh","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]},{"name":"Department of Urology, Medical University of Vienna","place":["Vienna, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.F.","family":"Chiu","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Lun","family":"Lo","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(05)68271-7","article-title":"Treatment for benign prostatic hyperplasia among community dwelling men: the Olmsted County study of urinary symptoms and health status","volume":"162","author":"Jacobsen","year":"1999","journal-title":"J Urol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12197","article-title":"Short-stay transurethral prostate surgery: a randomized controlled trial comparing transurethral resection in saline bipolar transurethral vaporization of the prostate with monopolar transurethral resection","volume":"8","author":"Yee","year":"2015","journal-title":"Asian J Endosc Surg"},{"key":"B3","article-title":"Bipolar transurethral vapourisation versus monopolar transurethral resection of prostate: a randomized controlled trial","volume":"23","author":"Ng","year":"2017","journal-title":"Hong Kong Med J"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2025.04.025","article-title":"Selecting minimally invasive surgical treatments for benign prostatic hyperplasia: a clinical consultation guide","volume":"11","author":"Chiu","year":"2025","journal-title":"Eur Urol Focus"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2025.11.003","article-title":"The \u201cswipe\u201d technique for prostatic urethral lift: a comparative analysis of 200 patients in a prospective cohort","volume":"14","author":"Siu","year":"2025","journal-title":"Prostate Int"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2025.08.001","article-title":"Transurethral water vapor therapy (Rez\u016bm) for acute urinary retention with obstructive uropathy: a prospective cohort study with one-year follow-up","volume":"13","author":"Siu","year":"2025","journal-title":"Prostate Int"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-025-00979-4","article-title":"Treatment cycles per unit prostate volume (CPV) for transurethral water vapor therapy (Rezum) in catheter-dependent patients","volume":"29","author":"Siu","year":"2025","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"B8","volume-title":"Presented at the EAU annual congress Paris","year":"2024"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.06.017","article-title":"A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update","volume":"67","author":"Cornu","year":"2015","journal-title":"Eur Urol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41391-019-0135-4","article-title":"Efficacy and safety of enucleation vs. resection of prostate for treatment of benign prostatic hyperplasia: a meta-analysis of randomized controlled trials","volume":"22","author":"Zhang","year":"2019","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02654-5","article-title":"Thulium fiber laser: the new player for kidney stone treatment? 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