{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:47:11Z","timestamp":1774936031728,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Stroke"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To capture real-world use and outcomes from chronic stroke survivors with arm and hand impairment implanted with a paired vagus nerve stimulation (Paired VNS) device. The FDA-approved Vivistim Paired VNS System combines VNS with upper limb rehabilitation to reduce upper-extremity motor deficits and improve function in chronic stroke survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational, postmarket patient registry collecting outcomes data from individuals who receive Vivistim for stroke recovery. Assessments will be conducted at baseline and at scheduled assessment timepoints over a period of up to 3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Adults aged 18 years or older with a history of stroke with moderate-to-severe upper limb deficits and clinically evaluated as appropriate candidates for Paired VNS Therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>Motor outcome assessments include the Fugl-Meyer Assessment-Upper Extremity, the Nine Hole Peg Test, and the Wolf Motor Function Test (optional). Patient-reported outcome assessments include a global quality of life questionnaire, Stroke Impact Scale, Motor Activity Log, and Beck Depression Inventory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The registry is designed to provide real-world evidence on the use and outcomes of Paired VNS. These data will characterize functional changes, patient experiences, and therapy utilization in a heterogeneous chronic stroke population, supporting optimization and broader integration of Paired VNS into stroke recovery pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/clinicaltrials.gov\/study\/NCT05301140<\/jats:ext-link>\n                      , identifier NCT05301140.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fstro.2026.1751659","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:10:24Z","timestamp":1774930224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study protocol for the Vivistim GRASP registry: capturing real-world outcomes of paired vagus nerve stimulation in the chronic stroke population"],"prefix":"10.3389","volume":"5","author":[{"given":"Shannon J.","family":"Doherty","sequence":"first","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia N.","family":"Prudente","sequence":"additional","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Adham Hinds","sequence":"additional","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pierce","sequence":"additional","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navzer D.","family":"Engineer","sequence":"additional","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Carrithers","sequence":"additional","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Hansen","sequence":"additional","affiliation":[{"name":"MicroTransponder, Inc.","place":["Austin, TX, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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