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Stroke"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>New therapeutic strategies to mitigate the devastating consequences of stroke are urgently needed, as restoration of blood flow is currently the only and limited available treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In our study, we employed a comprehensive combination of\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      stroke models to investigate the therapeutic potential of the DX243. Specifically, we used glutamate and oxygen-glucose deprivation\/reoxygenation (OGD) treatment models to mimic ischemic conditions\n                      <jats:italic>in vitro<\/jats:italic>\n                      . To transpose these data\n                      <jats:italic>in vivo<\/jats:italic>\n                      , we used the middle cerebral artery occlusion (MCAO) model to induce an ischemic stroke in male C57BL\/6J mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrated that DX243 significantly increased ATP production following glutamate treatment and neuronal viability following OGD.Forty-eight hours after 1 h of MCAO, mice that received one subcutaneous injection of DX243 presented a reduced infarct volume and preserved motor coordination on the rotarod, while effects on open field locomotion were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results highlight the promising neurorestorative properties of this new molecule and suggest its potential as a therapeutic agent for stroke patients. Further investigations in preclinical and clinical settings are warranted to elucidate its full therapeutic potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fstro.2026.1802085","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:24:24Z","timestamp":1781879064000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beneficial effects of the novel first-in-class compound DX243 on ischemic outcomes following in vitro and in vivo models of stroke"],"prefix":"10.3389","volume":"5","author":[{"given":"Quentin","family":"Marlier","sequence":"first","affiliation":[{"name":"Dendrogenix","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Boreux","sequence":"additional","affiliation":[{"name":"Dendrogenix","place":["Li\u00e8ge, 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