{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:23:36Z","timestamp":1768289016907,"version":"3.49.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Hypothesis:<\/jats:bold> Recently, several lines of evidence have suggested that the inner ear is under hormonal control. It is likely that steroids have some influence on the inner ear.<\/jats:p><jats:p><jats:bold>Background:<\/jats:bold> Many clinicians have been empirically using steroids for the treatment of diseases associated with endolymphatic hydrops. The theoretical grounds for this are not clear, and there have been a number of debates on the effectiveness of steroid treatment. Furthermore, there are few reports on histological observations of the influences of steroids on the cochlea.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> Fifteen guinea pigs (30 ears) were divided into three groups. In the control group, physiological saline solution was administered intra-peritoneally for 3 days. In two steroid groups, 40 mg\/kg\/day of hydrocortisone or 4 mg\/kg\/day of dexamethasone was administered intra-peritoneally for 3 days. Extension of Reissner's membrane and volume change of the scala media were checked 6 h after the last administration. The degree of Reissner's membrane extension and volumetric change of the scala media were quantitatively measured with the use of a video-digitizer.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We did not identify any distinct changes in the cochlea of the control group. In contrast, the extension of Reissner's membrane and endolymphatic hydrops were observed in the animals in the steroid groups. Statistical analysis revealed that Reissner's membrane extended significantly in the steroid groups, and that the volume of the scala media also increased significantly.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This is the first report to investigate the effects of systemic administration of glucocorticoids on guineapig cochlea. The extension of Reissner's membrane and dilated endolymphatic space were evident in the steroid groups. However, the underlying mechanism of histological changes was not clear, marked care needs to be taken when administering steroids to patients with Meniere's disease whose histological feature is endolymphatic hydrops.<\/jats:p>","DOI":"10.3389\/fsurg.2020.596383","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T01:36:43Z","timestamp":1610501803000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Glucocorticoids on the Inner Ear"],"prefix":"10.3389","volume":"7","author":[{"given":"Taizo","family":"Takeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Kakigi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/j.1532-5415.1959.tb00357.x","article-title":"Meniere's disease; a new therapeutic approach","volume":"7","author":"Hauser","year":"1959","journal-title":"J Am Geriatr Soc"},{"key":"B2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/BF00453676","article-title":"Allergy, immunology, psychosomatic, hypo- and hypertonus","volume":"212","author":"Stahle","year":"1976","journal-title":"Arch Otorhinolaryngol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1159\/000385358","article-title":"Cortisone in clinical otorhino-laryngology","volume":"15","author":"Taillens","year":"1968","journal-title":"Adv Otorhinolaryngol"},{"key":"B4","article-title":"\u201cControversial aspects of Meniere's disease\u201d","author":"Beck","year":"1986","journal-title":"Georg Thieme Verlag Stuttgart and Thieme Inc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1177\/000348947908800501","article-title":"Autoimmune sensorineural hearing loss","volume":"88","author":"McCabe","year":"1979","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1159\/000407651","article-title":"Autoimmune sensorineural hearing loss as an aggravating factor in Meniere's disease","volume":"30","author":"Shea","year":"1983","journal-title":"Adv Otorhinolaryngol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0030-6665(20)30398-4","article-title":"Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for Meniere's disease","volume":"29","author":"Shea","year":"1996","journal-title":"Otolaryngol Clin North Am"},{"key":"B8","first-page":"196","article-title":"Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial","volume":"19","author":"Silverstein","year":"1998","journal-title":"Am J Otol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/014556130408300611","article-title":"Intratympanic steroid perfusion for the treatment of M\u00e9ni\u00e8re's disease: a retrospective study","volume":"83","author":"Dodson","year":"2004","journal-title":"Ear Nose Throat J"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1097\/00129492-200411000-00031","article-title":"Intratympanic steroid treatment: a review","volume":"25","author":"Doyle","year":"2004","journal-title":"Otol Neurotol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/0194599811429432","article-title":"Intratympanic treatment of intractable unilateral Meniere disease: gentamicin or dexamethasone? 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