{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:33:54Z","timestamp":1753893234995,"version":"3.41.2"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> The autoimmune process in Crohn's disease exacerbates destructive changes in the intestinal wall and leads to complications such as bleeding (21. 9%), strictures (21.6%), and abscesses (19.7%).<\/jats:p><jats:p><jats:bold>Case Presentation:<\/jats:bold> The case of a 32-year-old male patient with an 8-year history of Crohn's disease is presented. He was admitted for emergency indications with severe pain in the right lower quadrant, chills, and a fever reaching 39.0\u00b0C. The patient had anemia, hypocoagulation and immunodeficiency. Ultrasound and CT scans of the abdominal organs revealed an abscess in the right iliac region. It was immediately drained under ultrasound control and X-ray. A fistulogram showed the fistula between the abscess and the ileum. Routine antibiotic therapy selected in accordance with the sensitivity of the microflora and sanitization of the abscess cavity were not effective. The immunomodulatory therapy, intravenous administration of cryoprecipitate, and the introduction of fibrin glue into the abscess cavity were added to the treatment. After the treatment, the patient's immune status corresponded to normal, the abscess healed, and the fistula was closed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In patients suffering from Crohn's disease with the formation of an abscess and a long-term non-healing intestinal fistula, it is essential that the diagnostic algorithm includes the examination of the immune status. Treatment should include immunomodulators, intravenous administration of cryoprecipitate. To close the fistula in these patients, it is advisable to use fibrin glue that has a local immunomodulatory effect.<\/jats:p>","DOI":"10.3389\/fsurg.2021.616586","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T04:31:36Z","timestamp":1622781096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-Guided Percutaneous Drainage of Abdominal Abscess in a Patient With Crohn's Disease: A Case Report"],"prefix":"10.3389","volume":"8","author":[{"given":"Radmila V.","family":"Karpova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenia S.","family":"Russkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman N.","family":"Komarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arina A.","family":"Petrova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s12016-009-8133-2","article-title":"Crohn's disease: an immune deficiency state","volume":"38","author":"Marks","year":"2010","journal-title":"Clin Rev Allergy Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.3389\/fimmu.2020.554880","article-title":"Innate lymphoid cells in Crohn's disease","volume":"11","author":"Wu","year":"2020","journal-title":"Front Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"S395","DOI":"10.14309\/00000434-201710001-00716","article-title":"Complications of Crohn's disease and ulcerative colitis: understanding the lifetime risks","volume":"112","author":"Lichtenstein","year":"2017","journal-title":"Am. 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Gastroenterol"},{"key":"B4","unstructured":"Imminiligy assessment of Crohn's disease activity5767\n            ShumilovPV\n            KhandamirovaOO\n            ShchigolevaAE\n            RoumiantsevSA\n            ShchigolevaNE\n            DubrovskayaMI\n          Pediatria102015"},{"key":"B5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.22416\/1382-4376-2019-29-5-13-20","article-title":"New possibilities for the treatment of Crohn's disease","volume":"29","author":"Mamieva","year":"2019","journal-title":"Russ J Gastroenterol Hepatol Coloproctol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00535-018-1439-1","article-title":"Evidence-based clinical practice guidelines for inflammatory bowel disease","volume":"53","author":"Matsuoka","year":"2018","journal-title":"J Gastroenterol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3389\/fimmu.2021.622934","article-title":"Role of the IL23\/IL17 pathway in Crohn's disease","volume":"12","author":"Schmitt","year":"2021","journal-title":"Front Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fmed.2017.00126","article-title":"The role of cytokines in the fibrotic responses in crohn's disease","volume":"4","author":"Curciarello","year":"2017","journal-title":"Front Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3389\/fimmu.2020.00646","article-title":"An update review on the paneth cell as key to ileal Crohn's disease","volume":"11","author":"Wehkamp","year":"2020","journal-title":"Front Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2097274","DOI":"10.1155\/2016\/2097274","article-title":"The immunological basis of inflammatory bowel disease","volume":"2016","author":"Silva","year":"2016","journal-title":"Gastroenterol Res Pract."},{"key":"B11","doi-asserted-by":"publisher","first-page":"350","DOI":"10.18484\/2305-0047.2017.4.350","article-title":"Effect of cryoprecipitate on liver regeneration in cirrhosis","volume":"25","author":"Chernousov","year":"2017","journal-title":"Novosti Khirurgii."},{"key":"B12","unstructured":"The use of fibrin glue as a reparation stimulator in treatment of patients with unformed intestinal fistulae218\n            ChernousovAF\n            KhorobrykhTV\n            IshchenkoOV\n            VasnevOS\n          Herald Surg Gastroenterol32009"},{"key":"B13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1017\/CBO9781139855952.063","volume-title":"Abdominal abscess, In: Clinical Infectious Disease, Second Edition","author":"Pharaon","year":"2015"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.616586\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T04:31:40Z","timestamp":1622781100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.616586\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,4]]},"references-count":13,"alternative-id":["10.3389\/fsurg.2021.616586"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2021.616586","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2021,6,4]]},"article-number":"616586"}}