{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:08:24Z","timestamp":1790878104563,"version":"4.1.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Angiotensin-converting enzyme inhibitors associated angioedema involving the upper aerodigestive tract is indisputably a hazardous airway condition which is clinically poorly recognized and frequently underestimated. We describe and present case of a 70-year old man on ramipril who developed massive tongue swelling post-operatively after unremarkable laryngeal mask anaesthesia which was fortuitously managed conservatively. High index of suspicion, timely recognition and knowledge of pathophysiology and the clinical course should guide airway and further supportive management in these patients.<\/jats:p>","DOI":"10.3389\/fsurg.2021.631456","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T16:58:37Z","timestamp":1616432317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Compromised Airway Following Anesthesia and Its Correlation With the Use of ACE Inhibitors\u2014An Unexpected Clinical Event and Review of Literature"],"prefix":"10.3389","volume":"8","author":[{"given":"Sanjeev","family":"Mohanty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bangaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaran","family":"Gnanasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.4103\/0972-5229.130583","article-title":"Difficult extubation after large tongue swelling in intensive care unit","volume":"18","author":"Raut","year":"2014","journal-title":"Indian J Crit Care Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1007\/BF03022528","article-title":"Brief review: angiotensin converting enzyme inhibitors and angioedema: anesthetic implications","volume":"53","author":"Sarkar","year":"2006","journal-title":"Can J Anaesth"},{"key":"B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1865-1380-5-39","article-title":"Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema","volume":"5","author":"Bernstein","year":"2012","journal-title":"Int J Emerg Med"},{"key":"B4","first-page":"983","article-title":"Angioedema after angiotensin-converting enzyme inhibitors","volume":"74","author":"Korzeniowska","year":"2017","journal-title":"Acta Pol Pharm"},{"key":"B5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/20009666.2019.1698259","article-title":"Clinical features of angioedema induced by renin-angiotensin-aldosterone system inhibition: a retrospective analysis of 84 patients","volume":"9","author":"Pfauea","year":"2019","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"B6","doi-asserted-by":"publisher","first-page":"576","DOI":"10.12659\/AJCR.901960","article-title":"Drug induced inhibition of angiotensin converting enzyme and dipeptidyl peptidase 4 results in nearly therapy resistant bradykinin induced angioedema. 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