{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:49:46Z","timestamp":1788648586239,"version":"build-2803163510"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008616","name":"Rush University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008616","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> Benign endobronchial tumors are rare entities that can be difficult to diagnose because they often present with non-specific symptoms and vague radiographic findings. The current study reviews the clinical, radiologic and pathologic features, diagnosis, and treatment of patients with benign endobronchial tumors.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We examined the charts of all patients who presented with biopsy-proven benign endobronchial tumors at a tertiary-care academic medical center between 1993 and 2018. Pertinent clinicopathologic and radiologic data were analyzed, with particular attention paid to treatment modalities and mean overall patient survival.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 28 cases were identified. The most common benign neoplasm was hamartoma (37%), followed by lipoma (19%), squamous papilloma (11%), pleomorphic adenoma (7%), mucin gland adenoma (7%), papillary adenoma (3%), hemangioma (3%), neurofibroma (3%), leiomyoma (3%), and papillomatosis (3%). Cough (58%), shortness of breath (44%), and hemoptysis (15%) were the most frequent presentations. Most cases demonstrated well-defined submucosal or pedunculated endobronchial lesions with segmental pneumonia or atelectasis on imaging. Histologic diagnosis was obtained by endobronchial resection in 43% of patients, thoracoscopic lobectomy in 36%, endobronchial biopsy in 18%, and thoracoscopic wedge resections in 3%. All procedures were performed with no intraoperative or in-hospital deaths (mean overall survival: 20.2 years).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Benign endobronchial tumors typically present as well-defined submucosal and\/or pedunculated lesions, and may lead to post-obstructive complications. Endobronchial resection is the preferred strategy for diagnosis and treatment of these tumors.<\/jats:p>","DOI":"10.3389\/fsurg.2021.644656","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T06:37:06Z","timestamp":1614926226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Benign Endobronchial Tumors: A Clinicopathologic Review"],"prefix":"10.3389","volume":"8","author":[{"given":"Joshua E.","family":"Insler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Seder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya B.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/LBR.0000000000000460","article-title":"Incidence, etiology, and clinicopathologic features of endobronchial benign lesions: a 10-year consecutive retrospective study","volume":"25","author":"Marchioni","year":"2018","journal-title":"J Bronchology Interv Pulmonol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1092-9134(97)80007-X","article-title":"Pathological and radiological correlation of endobronchial neoplasms: Part I, benign tumors","volume":"1","author":"Wilson","year":"1997","journal-title":"Ann Diagn Pathol"},{"key":"B3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1092-9134(98)80033-6","article-title":"Pathological\u2013radiological correlations: pathological and radiological correlation of endobronchial neoplasms: part II, malignant tumors","volume":"2","author":"Wilson","year":"1998","journal-title":"Ann Diagn Pathol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0096-5588(20)31430-6","article-title":"Lipoma of the bronchus: discussion of benign neoplasms and report of a case of endobronchial lipoma","volume":"15","author":"Watts","year":"1946","journal-title":"J Thoracic Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/BF00941804","article-title":"Benign tumors of the lung. 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