{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:34:06Z","timestamp":1753893246718,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017052","name":"NSFC-Liaoning Joint Fund","doi-asserted-by":"publisher","award":["81972749"],"award-info":[{"award-number":["81972749"]}],"id":[{"id":"10.13039\/100017052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>In this work, we reported a young man complaining of asthenia and intermittent fever for 10 days, and an ultrasound showed an undefined lesion on his liver. Facing the patient's situation with severe agranulocytosis, anemia, and thrombocytopenia, we passed through a tough diagnostic process for choosing an appropriate treatment for him with an ambiguous result of pathological biopsy. The undefined liver lesion was successfully solved by withdrawing the androgen for observation, without lobectomy. The lesion gradually diminished over 2 years of follow-up.<\/jats:p>","DOI":"10.3389\/fsurg.2021.665367","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T12:18:56Z","timestamp":1626265136000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: An Undefined Liver Lesion in a Young Man With Severe Aplastic Anemia: A Teachable Moment"],"prefix":"10.3389","volume":"8","author":[{"given":"Jin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidong","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s005350070081","article-title":"Multiple hepatic adenomas caused by long-term administration of androgenic steroids for aplastic anemia in association with familial adenomatous polyposis","volume":"35","author":"Nakao","year":"2000","journal-title":"J Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1309\/AJCPK1ZC9WNHCCMU","article-title":"HepPar-1, and Glypican-3 are the most effective panel of markers in distinguishing hepatocellular carcinoma from metastatic tumor on fine-needle aspiration specimens","volume":"138","author":"Timek","year":"2012","journal-title":"Am J Clin Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/dc.24353","article-title":"Extramedullary hematopoiesis: clinical and cytological features","volume":"48","author":"Gargi","year":"2020","journal-title":"Diagn Cytopathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0140-6736(73)92594-4","article-title":"Possible association between benign hepatomas and oral contraceptives","volume":"2","author":"Baum","year":"1973","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/hep.21068","article-title":"Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC","volume":"43","author":"Zucman-Rossi","year":"2006","journal-title":"Hepatology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1097\/PAS.0000000000000576","article-title":"Hepatocellular neoplasms arising in association with androgen use","volume":"40","author":"Gupta","year":"2016","journal-title":"Am J Surg Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1148\/radiol.2015142366","article-title":"Morphologic and molecular features of hepatocellular adenoma with gadoxetic acid-enhanced MR imaging","volume":"277","author":"Ba-Ssalamah","year":"2015","journal-title":"Radiology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1136\/gutjnl-2013-306678","article-title":"The driving circuit of HBx and androgen receptor in HBV-related hepatocarcinogenesis","volume":"63","author":"Wang","year":"2014","journal-title":"Gut."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1002\/hep.29715","article-title":"Significance and mechanism of androgen receptor overexpression and androgen receptor\/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma","volume":"67","author":"Zhang","year":"2018","journal-title":"Hepatology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0140-6736(20)31538-5","article-title":"Androgen-receptor-positive hepatocellular carcinoma in a transgender teenager taking exogenous testosterone","volume":"396","author":"Lin","year":"2020","journal-title":"Lancet."}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.665367\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T12:18:59Z","timestamp":1626265139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.665367\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,14]]},"references-count":10,"alternative-id":["10.3389\/fsurg.2021.665367"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2021.665367","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2021,7,14]]},"article-number":"665367"}}