{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:10:32Z","timestamp":1780387832835,"version":"3.54.1"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Epithelioid angiosarcoma arising in schwannoma is an extremely rare mesenchymal tumor that accounts for only 1 to 2% of all sarcomas. This type of tumor occurs in all parts of the body, most often in the skin and soft tissues and rarely in the mediastinum. The present study describes the case of an asymptomatic, 58-year-old male who presented with epithelioid angiosarcoma in the posterior mediastinum during a physical examination. Enhanced computed tomography of the chest revealed a 3.5 \u00d7 3.1-cm mass in the posterior mediastinum. Thoracoscopic mediastinal mass resection was performed under general anesthesia due to the possibility that the tumor was malignant. Pathological examination revealed the presence of angiosarcoma and schwannoma components. Immunohistochemical staining for cluster of differentiation (CD) 31, CD34, early growth response (EGR), vimentin, Sry-related HMG box (SOX)-10 and S-100 was strongly positive. The patient recovered and was discharged on postoperative day 5. Two months postsurgery, the patient returned for evaluation, and no evidence of tumor recurrence was observed.<\/jats:p>","DOI":"10.3389\/fsurg.2021.666389","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T04:42:32Z","timestamp":1622176952000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Posterior Mediastinal Epithelioid Angiosarcoma Arising in Schwannoma: A Case Report and Review of the Literature"],"prefix":"10.3389","volume":"8","author":[{"given":"Yingming","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangbiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1097\/00000478-199611000-00014","article-title":"Angiosarcoma arising in a solitary schwannoma (neurilemoma) of the sciatic nerve","volume":"20","author":"Trassard","year":"1996","journal-title":"Am J Surg Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5606\/tgkdc.dergisi.2018.14795","article-title":"Mediastinal epithelioid angiosarcoma arising in schwannoma: the first case in the literature","volume":"26","author":"Demir\u00f6z","year":"2018","journal-title":"Turk Gogus Kalp Damar Cerrahisi Derg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1046\/j.1365-2559.1999.00714.x","article-title":"Intraneural angiosarcoma and angiosarcoma arising in benign and malignant peripheral nerve sheath tumours: clinicopathological and immunohistochemical analysis of four cases","volume":"35","author":"Mentzel","year":"1999","journal-title":"Histopathology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00000478-200101000-00002","article-title":"Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases","volume":"25","author":"McMenamin","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1017\/S0022215106003070","article-title":"Intracranial angiosarcoma arising from a schwannoma","volume":"121","author":"Ito","year":"2007","journal-title":"J Laryngol Otol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.humpath.2007.02.019","article-title":"epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review","volume":"38","author":"Lee","year":"2007","journal-title":"Hum Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1440-1827.2012.02827.x","article-title":"Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature","volume":"62","author":"Li","year":"2012","journal-title":"Pathol Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12105-014-0577-x","article-title":"Angiosarcoma developing in a vagal schwannoma: a rare case report","volume":"9","author":"Mahajan","year":"2015","journal-title":"Head Neck Pathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12957-016-0789-5","article-title":"Epithelioid angiosarcoma arising in schwannoma of the kidney: report of the first case and review of the literature","volume":"14","author":"Iannaci","year":"2016","journal-title":"World J Surg Oncol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3760\/cma.j.issn.0529-5807.2019.02.019","article-title":"Epithelioid angiosarcoma arising in Schwannoma: report of a case","volume":"48","author":"He","year":"2019","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"B11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4103\/2006-8808.184941","article-title":"Malignant transformation of vagal nerve schwannoma in to angiosarcoma: a rare event","volume":"7","author":"Agarwal","year":"2015","journal-title":"J Surg Tech Case Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1002\/1097-0142(20001001)89:7<1577::AID-CNCR23>3.0.CO;2-2","article-title":"Schwannoma with angiosarcoma. 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