{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:34:11Z","timestamp":1753893251054,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Epithelioid haemangioendothelioma is a rare angiogenic tumour originating from vascular endothelial or pre-endothelial cells, and it can occur anywhere in the body, such as the liver, lung, bone, spleen, lymph nodes, parotid gland, and thyroid. In the fifth revision of the WHO classification, epithelioid haemangioendothelioma (EHE) was described as a malignant vascular neoplasm composed of epithelioid endothelial cells, distinct from epithelioid angiosarcoma. We, herein, report one patient with EHE of the left upper mediastinum who underwent resection and radiotherapy during the first therapeutic process. Multiple metastases occurred in the thoracic vertebrae 6 years later, and resection and multiple radiotherapies were performed. The condition of the patient remained stable at the last review in October 2020, and it has been more than 8 years since her first admission. The reasonable \u201ctake-away\u201d lessons from the case are active treatment and prolonged surveillance.<\/jats:p>","DOI":"10.3389\/fsurg.2021.678572","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T06:41:40Z","timestamp":1633675300000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Long-Term Observation and Treatment of Epithelioid Haemangioendothelioma of the Mediastinum: A Case Report"],"prefix":"10.3389","volume":"8","author":[{"given":"Qiuli","family":"Zhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhoupeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guansheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangfeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4081\/oncol.2014.259","article-title":"Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor","volume":"13","author":"Sardaro","year":"2014","journal-title":"Oncol Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40001-019-0375-8","article-title":"Clinical characteristics of epithelioid hemangioen -dothelioma: a single-center retrospective study","volume":"24","author":"Wu","year":"2019","journal-title":"Eur J Med Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/1097-0142(19820901)50:5<970::AID-CNCR2820500527>3.0.CO;2-Z","article-title":"Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma","volume":"50","author":"Weiss","year":"1982","journal-title":"Cancer."},{"key":"B4","first-page":"259","article-title":"Epithelioid hemangioendothelioma and related lesions","volume":"3","author":"Weiss","year":"1986","journal-title":"Semin Diagn Pathol."},{"volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","year":"2020","key":"B5"},{"key":"B6","doi-asserted-by":"publisher","first-page":"864","DOI":"10.12659\/AJCR.915874","article-title":"Epithelioid hemangioendothelioma: a rare case of an aggressive vascular malignancy","volume":"20","author":"Lytle","year":"2019","journal-title":"Am J Case Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e6142","DOI":"10.1097\/MD.0000000000006142","article-title":"Epithelioid hemangioendothelioma of right innominate vein mimics a teratoma: a case report","volume":"96","author":"Wan","year":"2017","journal-title":"Medicine."},{"key":"B8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.5090\/kjtcs.2018.51.6.419","article-title":"An aggressive large epithelioid hemangioendothe lioma of the anterior mediastinum in a young woman","volume":"51","author":"Dutta","year":"2018","journal-title":"Korean J Thorac Cardiovasc Surg."},{"key":"B9","first-page":"308","article-title":"Epithelioid hemangioendothelioma of the anterior skull base: what is the optimal treatment?","volume":"15","author":"Wong","year":"2009","journal-title":"Hong Kong Med J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.cancergencyto.2006.03.018","article-title":"Chromosome analysis and molecular cytogenetic investigations of an epithelioid hemangioendothe -lioma","volume":"169","author":"Tsarouha","year":"2006","journal-title":"Cancer Genet Cytogenet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40792-017-0294-2","article-title":"Epithelioid hemangioendothelioma of the thyroid: a case report","volume":"3","author":"Ono","year":"2017","journal-title":"Surg Case Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s13691-018-0351-0","article-title":"Epithelioid hemangioendothelioma of the parotid gland: a case report","volume":"8","author":"Koide","year":"2018","journal-title":"Int Cancer Conf J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"570","DOI":"10.20471\/acc.2018.57.03.21","article-title":"Primary epithe- lioid hemangioendothelioma in the cerebellum: case report with reference to drastic change in the who classification","volume":"57","author":"Omerhod\u017di\u0107","year":"2018","journal-title":"Acta Clin Croat."},{"key":"B14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00595-007-3712-4","article-title":"Pulmonary epithelioid hemangioendothelioma\u2013interferon 2-alpha treatment\u2013case report","volume":"76","author":"Radzikowska","year":"2008","journal-title":"Pneumonol Alergol Pol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"C866","DOI":"10.1152\/ajpcell.00238.2003","article-title":"A key angiogenic role of monocyte Chemoattractant protein-1 in hemangio -endothelioma proliferation","volume":"287","author":"Gordillo","year":"2004","journal-title":"Am J Physiol Cell Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2995\/jacsurg.26.633","article-title":"A case of mediastinal epithelioid hemangioen -dothelioma (EHE) treated via resection of the right brachiocephalic vein","volume":"26","author":"Hitoshi","year":"2012","journal-title":"J Jpn Assoc Chest Surg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jvs.2011.06.108","article-title":"A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm","volume":"55","author":"Osawa","year":"2012","journal-title":"J Vasc Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3892\/ol.2016.4149","article-title":"Typical CT and MRI signs of hepatic epithelioid hemangioendothelioma","volume":"11","author":"Gan","year":"2016","journal-title":"Oncol Lett."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e4348","DOI":"10.1097\/MD.0000000000004348","article-title":"Epithelioid hemangioendothe -lioma in the thorax: clinicopathologic, CT, PET, and prognostic features","volume":"95","author":"Woo","year":"2016","journal-title":"Medicine."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e402","DOI":"10.1097\/RLU.0000000000000339","article-title":"Multi-focal epithelioid hemangioendo -thelioma of the lower limbs detected by 18F-FDG PET\/MRI","volume":"39","author":"Treglia","year":"2014","journal-title":"Clin Nucl Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1378\/chest.11-0039","article-title":"Clinical patterns and outcome in epithelioid hemangioendo- thelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer","volume":"140","author":"Lau","year":"2011","journal-title":"Chest."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/j.athoracsur.2006.06.068","article-title":"Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature","volume":"82","author":"Bagan","year":"2006","journal-title":"Ann Thorac Surg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"250","DOI":"10.21037\/jss.2017.05.05","article-title":"Epithelioid hemangioendothelioma of the spine: case report and review of the literature","volume":"3","author":"Albakr","year":"2017","journal-title":"J Spine Surg"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.678572\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T06:41:48Z","timestamp":1633675308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.678572\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":23,"alternative-id":["10.3389\/fsurg.2021.678572"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2021.678572","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2021,10,5]]},"article-number":"678572"}}