{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:36:48Z","timestamp":1784011008756,"version":"3.55.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> The relationship between the selective parathyroid gland (PG) autotransplantation and hypoparathyroidism is still not completely clear. The aim was to ascertain whether the number of autotransplanted PGs affected the incidence of hypoparathyroidism and recovery of parathyroid function in the long-term for patients with papillary thyroid carcinoma (PTC).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A retrospective cohort study included all patients with PTC who had underwent primary total thyroidectomy with central neck dissection between January 2013 and December 2017. The patients were divided into three groups (0, 1, and 2 PGs autotransplanted, respectively).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of the 2,477 patients, 634 (25.6%) received no PG autotransplantation, 1,078 (43.5%) and 765 (30.9%) were autotransplanted 1 and 2 PGs, respectively, and the incidence of permanent hypoparathyroidism (&amp;gt;1 year) was 1.7%, 0.7%, and 0.4% (<jats:italic>P<\/jats:italic> = 0.0228). Both 1 or 2 PGs autotransplanted increased the incidence of transient biochemical hypoparathyroidism (odds ratio [OR], 1.567; 95% confidence interval [CI], 1.258\u20131.953; <jats:italic>P<\/jats:italic> &amp;lt; 0.0001; OR, 2.983; 95% CI, 2.336\u20133.810; <jats:italic>P<\/jats:italic> &amp;lt; 0.0001, respectively) but reduced the incidence of permanent hypoparathyroidism (OR, 0.373; 95% CI, 0.145\u20130.958; <jats:italic>P<\/jats:italic> = 0.0404; OR, 0.144; 95% CI, 0.037\u20130.560; <jats:italic>P<\/jats:italic> = 0.0052, respectively). Both 1 or 2 PGs autotransplanted did not independently influence the occurrence of hypocalcemia symptoms.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Selective parathyroid autotransplantation is less likely to lead to post-operative symptomatic hypocalcemia, although it could lead to a transient decrease in parathyroid hormone. However, in the long run, it is still an effective strategy to preserve parathyroid function.<\/jats:p>","DOI":"10.3389\/fsurg.2021.683041","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T04:47:37Z","timestamp":1624855657000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Selective Parathyroid Autotransplantation During Total Thyroidectomy for Papillary Thyroid Carcinoma: A Cohort Study"],"prefix":"10.3389","volume":"8","author":[{"given":"Yuxuan","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0221173","DOI":"10.1371\/journal.pone.0221173","article-title":"The effectiveness of parathyroid gland autotransplantation in preserving parathyroid function during thyroid surgery for thyroid neoplasms: a meta-analysis","volume":"14","author":"Wang","year":"2019","journal-title":"PLoS ONE."},{"key":"B3","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1089\/thy.2017.0309","article-title":"American thyroid association statement on postoperative hypoparathyroidism: diagnosis, prevention, and management in adults","volume":"28","author":"Orloff","year":"2018","journal-title":"Thyroid."},{"key":"B4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s12020-019-01858-4","article-title":"Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review","volume":"64","author":"Harsl\u00f8f","year":"2019","journal-title":"Endocrine."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.21037\/gs-20-486","article-title":"Surgical strategy when identifying less than four parathyroid glands during total thyroidectomy: a retrospective cohort study","volume":"10","author":"Xing","year":"2021","journal-title":"Gland Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/bjs.9676","article-title":"Importance of in situ preservation of parathyroid glands during total thyroidectomy","volume":"102","author":"Lorente-Poch","year":"2015","journal-title":"Bri J Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.surg.2017.12.025","article-title":"Does the number of parathyroid glands autotransplanted affect the incidence of hypoparathyroidism and recovery of parathyroid function?","volume":"164","author":"Su","year":"2018","journal-title":"Surgery"},{"key":"B8","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1046\/j.1445-2197.2002.02580.x","article-title":"Parathyroid autotransplantation during thyroidectomy","volume":"72","author":"Lo","year":"2002","journal-title":"ANZ J Surg"},{"key":"B9","first-page":"190","article-title":"Routine parathyroid autotransplantation during total thyroidectomy: a procedure with predictable outcome","volume":"63","author":"Ahmed","year":"2013","journal-title":"JPMA."},{"key":"B10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ijsu.2017.01.117","article-title":"Parathyroid reimplantation with PR-FaST technique in unselected patients during thyroidectomy. 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