{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:34:22Z","timestamp":1753893262958,"version":"3.41.2"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The established criteria for determining whether to excise the cardia during laparoscopic surgery for gastrointestinal stromal tumors in the esophagogastric junction (EGJ-GISTs) remain controversial. This retrospective multicenter study was conducted to develop a nomogram for predicting the risk of the cardia excision during laparoscopic surgery for EGJ-GISTs.<\/jats:p><jats:p><jats:bold>Material and Methods:<\/jats:bold> We reviewed data from 2,127 gastric-GISTs (g-GISTs) patients without distant metastases in four hospital between June 2012 and June 2020. Of those, according to the including criteria, 184 patients [Guangdong Provincial Hospital of Chinese Medicine (<jats:italic>n<\/jats:italic> = 81), Nanfang Hospital of Southern Medical University (<jats:italic>n<\/jats:italic> = 60), Guangdong General Hospital (<jats:italic>n<\/jats:italic> = 34), and The Third Affiliated Hospital of Southern Medical University (<jats:italic>n<\/jats:italic> = 9)] with EGJ-GISTs were identified and included in this study. Factors contributing to risk of cardia excision were identified and used to create a nomogram. Nomogram performance was assessed using a bootstrapped concordance index (c-index) and calibration plots.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> According to the multivariate analysis, the distance from the margin of the tumor to the esophagogastric line (EG-line) (cm) (<jats:italic>OR<\/jats:italic> = 0.001, <jats:italic>95% CI<\/jats:italic>: 0.00001~0.056, <jats:italic>P<\/jats:italic> = 0.001) and tumor size (cm) (<jats:italic>OR<\/jats:italic> = 14.969, <jats:italic>95% CI<\/jats:italic>: 1.876~119.410, <jats:italic>P<\/jats:italic> = 0.011) were significantly related to likelihood of cardia structure excision in laparoscopic surgery for EGJ-GISTs. These two factors were used to generate a nomogram for predicting risk of cardia excision using a logistic regression model; a bootstrapped <jats:italic>C-index<\/jats:italic> of 0.988 (calibrated <jats:italic>C-index<\/jats:italic> = 0.987) indicated strong predictive ability, with broad calibration.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This nomogram based on distance from tumor margin to EG-line and tumor size may serve as a tool for predicting risk of cardia damage during laparoscopic removal of EGJ-GISTs to aid in selection of surgical methods and preoperative neoadjuvant therapy.<\/jats:p>","DOI":"10.3389\/fsurg.2021.712984","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T07:54:21Z","timestamp":1633938861000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nomogram for Predicting Risk of Esophagogastric Junction (EGJ) Resection During Laparoscopic Resection of Gastrointestinal Stromal Tumors in EGJ: A Retrospective Multicenter Study"],"prefix":"10.3389","volume":"8","author":[{"given":"Yuting","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yensheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.canep.2015.10.031","article-title":"Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies","volume":"40","author":"S\u00f8reide","year":"2016","journal-title":"Cancer Epidemiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.ejso.2019.05.002","article-title":"Resection of GIST in the duodenum and proximal jejunum: A retrospective analysis of outcomes","volume":"45","author":"Huang","year":"2019","journal-title":"Eur J Surg Oncol."},{"key":"B3","unstructured":"Clinical Practice Guidelines in Oncology. 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