{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:29:00Z","timestamp":1787027340577,"version":"build-2736575974"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To determine the effect of the serum albumin level on admission in patients with spontaneous subarachnoid hemorrhage (SAH).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 229 patients with SAH were divided into control and hypoalbuminemia groups. The serum albumin levels were measured. The data, including age, gender, co-existing medical conditions, risk factors, Hunt-Hess (H-H) grade on admission, Glasgow coma score (GCS) on admission, complications during hospitalizations, length of hospital stay, length of intensive care unit (ICU) stay, in-hospital mortality, survival rate, outcome at discharge, and the 6-month follow-up outcome, were compared between the two groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Older age, an increased number of patients who consumed an excess of alcohol, and a lower GCS on admission were findings in the hypoalbuminemia group compared to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001). The ratio of patients with H-H grade I on admission in the hypoalbuminemia group was decreased compared to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05). Patients with hypoalbuminemia were more likely to be intubated, and have pneumonia and cerebral vasospasm than patients with a normal albumin level on admission (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001). Furthermore, the length of hospital and ICU stays were longer in the hypoalbuminemia group than the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001). Hypoalbuminemia on admission significantly increased poor outcomes at discharge (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001). The number of patients with severe disability was increased and the recovery rate was decreased with respect to in-hospital outcomes in the hypoalbuminemia group than the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Hypoalbuminemia was shown to be associated with a poor prognosis in patients with SAH.\n                  <\/jats:p>","DOI":"10.3389\/fsurg.2021.719226","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T01:21:23Z","timestamp":1635211283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Predictive Value of the Serum Albumin Level on Admission in Patients With Spontaneous Subarachnoid Hemorrhage"],"prefix":"10.3389","volume":"8","author":[{"given":"Feng","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"B1","first-page":"182","article-title":"Chinese guideline for diagnosis and treatment of subarachnoid hemorrhage 2015","volume":"3","author":"Qiang","year":"2016","journal-title":"Chin J Neurol."},{"key":"B2","volume-title":"Clinical Observation on Treatment of Traumatic Subarachnoid Hemorrhage With Acupuncture And Medicine","author":"He","year":"2015"},{"key":"B3","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s12975-020-00867-0","article-title":"Aneurysmal subarachnoid hemorrhage: the last decade","volume":"12","author":"Neifert","year":"2020","journal-title":"Transl Stroke Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00234-003-1132-8","article-title":"MRI in acute subarachnoid hemorrhage; findings with a standardised stroke protocol","volume":"1","author":"Fiebach","year":"2004","journal-title":"Neuroradiology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/j.1365-2044.1996.tb07883.x","article-title":"The prognostic value of serial measurements of serum albumin concentration in patients admitted to an intensive care unit","volume":"51","author":"McCluskey","year":"1996","journal-title":"Anaesthesia."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1378\/chest.112.4.1035","article-title":"Predictors of outcome in cardiac surgical patients with prolonged intensive care stay","volume":"112","author":"Ryan","year":"1997","journal-title":"Chest."},{"key":"B7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/00007890-199907150-00014","article-title":"The impact of hypoalbuminemia in kidney-pancreas transplant recipients","volume":"68","author":"Becker","year":"1999","journal-title":"Transplantation."},{"key":"B8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/01.SLA.0000055547.93484.87","article-title":"Hypoalbuminemia in acute illness: is there a rationale for intervention? 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