{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:40:05Z","timestamp":1768002005990,"version":"3.49.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Transurethral resection of the prostate (TURP) is regarded as the \u201cgold standard\u201d for the treatment of benign prostatic hyperplasia (BPH) in elderly men. However, ~15% of patients who had undergone TURP had intraoperative and postoperative complications, such as bleeding, urinary incontinence and urethral stricture. Transperineal percutaneous laser ablation (TPLA) is a method that places the optical fibre directly into the prostate with the guidance of ultrasound imaging, and the percutaneous transperineal approach is performed distal to the urethra and rectum to protect these structures and reduce urethral or postoperative infection. Several studies on TPLA for BPH treatment have been reported recently; however, high-quality randomised controlled trial (RCT) to evaluate its efficacy, safety, and long-term follow up remain absent.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study is a multicentre, open-label RCT to assess the efficacy and safety of TPLA vs. TURP to treat BPH. We hypothesise that the TPLA has non-inferior efficacy to TURP in the International Prostate Symptom Score (IPSS) at 3 months changing from the baseline and lower incidence of post-surgery complications. One hundred and fourteen patients with BPH will be recruited at 19 sites and randomly assigned at 1:1 to TPLA or TURP groups. The patients will be followed up at 1, 3, 6, 12, and 24 months after the procedure.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> The study will be the first multicentre clinical trial including 16 participating centres in China, Italy, Switzerland, and Poland with relatively large sample size 114. By comprehensively compare the safety and efficacy of TPLA with TURP in patients with BPH, especially concerning the improvement of lower urinary tract symptoms (LUTS) and complication incidence, the study will help to illustrate the clinical value of TPLA and provide a beneficial alternative treatment for BPH patients.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold> The study has been registered on Chinese Clinical Trial Registry (<jats:ext-link>http:\/\/www.chictr.org.cn<\/jats:ext-link>), identifier [ChiCTR1900022739].<\/jats:p>","DOI":"10.3389\/fsurg.2021.755957","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T09:38:33Z","timestamp":1634636313000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The Design and Rationale of a Multicentre Randomised Controlled Trial Comparing Transperineal Percutaneous Laser Ablation With Transurethral Resection of the Prostate for Treating Benign Prostatic Hyperplasia"],"prefix":"10.3389","volume":"8","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weituo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheying","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nailong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biyun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16031","DOI":"10.1038\/nrdp.2016.31","article-title":"Benign prostatic hyperplasia","volume":"2","author":"Chughtai","year":"2016","journal-title":"Nat Rev Dis Primers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.pop.2019.02.003","article-title":"Benign prostatic hyperplasia","volume":"46","author":"Langan","year":"2019","journal-title":"Prim Care."},{"key":"B3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s11884-010-0067-2","article-title":"Benign prostatic hyperplasia and male lower urinary tract symptoms: epidemiology and risk factors","volume":"5","author":"Parsons","year":"2010","journal-title":"Curr Bladder Dysfunct Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"242","DOI":"10.23736\/S0393-2249.16.02815-0","article-title":"The influence of the medical treatment of LUTS on benign prostatic hyperplasia surgery: do we operate too late?","volume":"69","author":"Presicce","year":"2017","journal-title":"Minerva Urol Nefrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/S0140-6736(03)13073-5","article-title":"Benign prostatic hyperplasia","volume":"361","author":"Thorpe","year":"2003","journal-title":"Lancet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0084-4071(08)79002-X","article-title":"Current medical therapies for men with lower urinary tract symptoms and benign prostatic hyperplasia: achievements and limitations","volume":"10","author":"Roehrborn","year":"2008","journal-title":"Rev Urol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.eururo.2014.12.038","article-title":"EAU guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction","volume":"67","author":"Gratzke","year":"2015","journal-title":"Eur Urol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.eururo.2010.06.001","article-title":"Is classical transurethral resection of the prostate, the gold standard endoscopic treatment for benign prostate hyperplasia, in real danger of being replaced?","volume":"58","author":"Geavlete","year":"2010","journal-title":"Eur Urol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1056\/NEJM199501123320202","article-title":"A comparison of transurethral surgery with watchful waiting for moderate symptoms of benign prostatic hyperplasia. 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